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Conserved domains on  [gi|20149543|ref|NP_002623|]
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placenta growth factor isoform 1 precursor [Homo sapiens]

Protein Classification

PDGF/VEGF family growth factor( domain architecture ID 11255535)

PDGF/VEGF family growth factor binds to its receptor tyrosine kinase and regulates a variety of biological processes such as blood and lymphatic vessel development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-132 4.24e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 125.23  E-value: 4.24e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543     50 SYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 20149543    130 CRP 132
Cdd:smart00141  81 CRP 83
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-132 4.24e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 125.23  E-value: 4.24e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543     50 SYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 20149543    130 CRP 132
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 50-132 2.08e-31

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 108.23  E-value: 2.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543  50 SYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRS--GDRPSYVELTFSQHVR 127
Cdd:cd00135   1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPkrKPRSKLVEISFEEHTE 80


                ....*
gi 20149543 128 CECRP 132
Cdd:cd00135  81 CECRP 85
PDGF pfam00341
PDGF/VEGF domain;
52-130 6.46e-30

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 104.29  E-value: 6.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543    52 CRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKI---RSGDRPSYVELTFSQHVRC 128
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIeyaPRRPSPELVEVSFEEHVQC 80


                  ..
gi 20149543   129 EC 130
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 4-134 2.89e-22

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 86.98  E-value: 2.89e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543    4 MRLFPCFLQLLAGL-ALPAVPPQQWALSAGNGSSEVEvvPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLR 82
Cdd:PHA02661   1 MKLITTLQFAVALLlCMYNVPWCFSGSTGSSSASSLS--SWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRR 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 20149543   83 CTGCCGDENLHCVPVETANVTMQLLKI----RSGDRPSYVELTFSQHVRCECRPLR 134
Cdd:PHA02661  79 CGGCCNDESQICTPTETSNVTVTVMLTsvsgSTGATSNFQTISVEEHTKCKCEFKT 134
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-132 4.24e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 125.23  E-value: 4.24e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543     50 SYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 20149543    130 CRP 132
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 50-132 2.08e-31

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 108.23  E-value: 2.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543  50 SYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRS--GDRPSYVELTFSQHVR 127
Cdd:cd00135   1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPkrKPRSKLVEISFEEHTE 80


                ....*
gi 20149543 128 CECRP 132
Cdd:cd00135  81 CECRP 85
PDGF pfam00341
PDGF/VEGF domain;
52-130 6.46e-30

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 104.29  E-value: 6.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543    52 CRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKI---RSGDRPSYVELTFSQHVRC 128
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIeyaPRRPSPELVEVSFEEHVQC 80


                  ..
gi 20149543   129 EC 130
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 4-134 2.89e-22

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 86.98  E-value: 2.89e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149543    4 MRLFPCFLQLLAGL-ALPAVPPQQWALSAGNGSSEVEvvPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLR 82
Cdd:PHA02661   1 MKLITTLQFAVALLlCMYNVPWCFSGSTGSSSASSLS--SWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRR 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 20149543   83 CTGCCGDENLHCVPVETANVTMQLLKI----RSGDRPSYVELTFSQHVRCECRPLR 134
Cdd:PHA02661  79 CGGCCNDESQICTPTETSNVTVTVMLTsvsgSTGATSNFQTISVEEHTKCKCEFKT 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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