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Conserved domains on  [gi|324073295|ref|NP_001191243|]
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prolactin receptor isoform 6 precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 26-124 1.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324073295  26 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 103
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 324073295 104 QVRCKPDHGyWSAWSPATFIQ 124
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 26-124 1.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324073295  26 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 103
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 324073295 104 QVRCKPDHGyWSAWSPATFIQ 124
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 26-113 3.79e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 3.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324073295    26 PDPPLELAVEVKQPEdrkpYLWIKWSPPTliDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQV 105
Cdd:smart00060   1 PSPPSNLRVTDVTST----SVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 324073295   106 RCKPDHGY 113
Cdd:smart00060  75 RAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
27-118 2.27e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324073295   27 DPPLELAVEVKQPEdrkpYLWIKWSPPTLIDLK-TGwftllYEIRLKPEKAAEWEIHF--AGQQTEFKILSLHPGQKYLV 103
Cdd:pfam00041   1 SAPSNLTVTDVTST----SLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEV 71

                          90
                  ....*....|....*
gi 324073295  104 QVRCKPDHGyWSAWS 118
Cdd:pfam00041  72 RVQAVNGGG-EGPPS 85
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 26-124 1.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324073295  26 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 103
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 324073295 104 QVRCKPDHGyWSAWSPATFIQ 124
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 26-113 3.79e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 3.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324073295    26 PDPPLELAVEVKQPEdrkpYLWIKWSPPTliDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQV 105
Cdd:smart00060   1 PSPPSNLRVTDVTST----SVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 324073295   106 RCKPDHGY 113
Cdd:smart00060  75 RAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
27-118 2.27e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324073295   27 DPPLELAVEVKQPEdrkpYLWIKWSPPTLIDLK-TGwftllYEIRLKPEKAAEWEIHF--AGQQTEFKILSLHPGQKYLV 103
Cdd:pfam00041   1 SAPSNLTVTDVTST----SLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEV 71

                          90
                  ....*....|....*
gi 324073295  104 QVRCKPDHGyWSAWS 118
Cdd:pfam00041  72 RVQAVNGGG-EGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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