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Conserved domains on  [gi|291045307|ref|NP_001166937|]
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aladin isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-310 1.24e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 163 VASLAWKPlSASVLAVACQ-SCILIWtlDPTSLStrpssgCAQVLShpGHT-PVTSLAWAPSGGRLLSASPvDAAIRVWD 240
Cdd:cd00200  138 VNSVAFSP-DGTFVASSSQdGTIKLW--DLRTGK------CVATLT--GHTgEVNSVAFSPDGEKLLSSSS-DGTIKLWD 205

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 291045307 241 VSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWeaQMWTCERWPTLSG---RCQTGCWSPDGSRL 310
Cdd:cd00200  206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGhtnSVTSLAWSPDGKRL 276
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-310 1.24e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 163 VASLAWKPlSASVLAVACQ-SCILIWtlDPTSLStrpssgCAQVLShpGHT-PVTSLAWAPSGGRLLSASPvDAAIRVWD 240
Cdd:cd00200  138 VNSVAFSP-DGTFVASSSQdGTIKLW--DLRTGK------CVATLT--GHTgEVNSVAFSPDGEKLLSSSS-DGTIKLWD 205

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 291045307 241 VSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWeaQMWTCERWPTLSG---RCQTGCWSPDGSRL 310
Cdd:cd00200  206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGhtnSVTSLAWSPDGKRL 276
WD40 COG2319
WD40 repeat [General function prediction only];
209-311 2.07e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 2.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 209 PGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWT 287
Cdd:COG2319  201 TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                         90       100
                 ....*....|....*....|....*
gi 291045307 288 CERWPT-LSGRCQTGCWSPDGSRLL 311
Cdd:COG2319  280 LLRTLTgHSGGVNSVAFSPDGKLLA 304
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 204-240 9.01e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 9.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 291045307   204 QVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 240
Cdd:smart00320   4 LLKTLKGHTgPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
204-240 2.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 291045307  204 QVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 240
Cdd:pfam00400   3 LLKTLEGHTgSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-310 1.24e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 163 VASLAWKPlSASVLAVACQ-SCILIWtlDPTSLStrpssgCAQVLShpGHT-PVTSLAWAPSGGRLLSASPvDAAIRVWD 240
Cdd:cd00200  138 VNSVAFSP-DGTFVASSSQdGTIKLW--DLRTGK------CVATLT--GHTgEVNSVAFSPDGEKLLSSSS-DGTIKLWD 205

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 291045307 241 VSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWeaQMWTCERWPTLSG---RCQTGCWSPDGSRL 310
Cdd:cd00200  206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGhtnSVTSLAWSPDGKRL 276
WD40 COG2319
WD40 repeat [General function prediction only];
209-311 2.07e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 2.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 209 PGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWT 287
Cdd:COG2319  201 TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                         90       100
                 ....*....|....*....|....*
gi 291045307 288 CERWPT-LSGRCQTGCWSPDGSRLL 311
Cdd:COG2319  280 LLRTLTgHSGGVNSVAFSPDGKLLA 304
WD40 COG2319
WD40 repeat [General function prediction only];
163-310 9.42e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 9.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 163 VASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSsgcaqvlshpGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDV 241
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT----------GHTgAVRSVAFSPDGKTLASGS-ADGTVRLWDL 149

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 291045307 242 STETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQmwTCERWPTLSG---RCQTGCWSPDGSRL 310
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGhtgAVRSVAFSPDGKLL 219
WD40 COG2319
WD40 repeat [General function prediction only];
163-311 1.84e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 1.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 163 VASLAWKPlSASVLAVACQSC-ILIWTLDPTSlstrpssgCAQVLSHPGHtPVTSLAWAPSGGRLLSASPvDAAIRVWDV 241
Cdd:COG2319  249 VRSVAFSP-DGRLLASGSADGtVRLWDLATGE--------LLRTLTGHSG-GVNSVAFSPDGKLLASGSD-DGTVRLWDL 317

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 291045307 242 STETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQmwTCERWPTLSG---RCQTGCWSPDGSRLL 311
Cdd:COG2319  318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA--TGELLRTLTGhtgAVTSVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-313 3.30e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 3.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 163 VASLAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCAQVLShpGHT-PVTSLAWAPSGgRLLSASPVDAAIRVWDV 241
Cdd:cd00200   54 VRDVAASADGTYLASGSSDKTIRLWDLE--------TGECVRTLT--GHTsYVSSVAFSPDG-RILSSSSRDKTIKVWDV 122

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 291045307 242 STETCVPLpwFRG--GGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTCERwpTLSG---RCQTGCWSPDGSRLLFT 313
Cdd:cd00200  123 ETGKCLTT--LRGhtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGhtgEVNSVAFSPDGEKLLSS 195
WD40 COG2319
WD40 repeat [General function prediction only];
184-310 4.42e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 4.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 184 ILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPvDAAIRVWDVSTETCVPLPWFRGGGVTNLLWS 263
Cdd:COG2319   51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA-DGTVRLWDLATGLLLRTLTGHTGAVRSVAFS 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 291045307 264 PDGSKILATTPSAVFRVWEAQMWTCERwpTLSG---RCQTGCWSPDGSRL 310
Cdd:COG2319  130 PDGKTLASGSADGTVRLWDLATGKLLR--TLTGhsgAVTSVAFSPDGKLL 177
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 160-282 5.08e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 5.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 160 QRNVASLAWKPLSASVLAVACQSCILIWTLDPTSlstrpssgCAQVLShpGHT-PVTSLAWAPSGgRLLSASPVDAAIRV 238
Cdd:cd00200  177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK--------CLGTLR--GHEnGVNSVAFSPDG-YLLASGSEDGTIRV 245

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 291045307 239 WDVSTETCVPLpwFRG--GGVTNLLWSPDGSKILATTPSAVFRVWE 282
Cdd:cd00200  246 WDLRTGECVQT--LSGhtNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
163-284 1.54e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 163 VASLAWKPlSASVLAVACQSC-ILIWTLDPTSLstrpssgcaqVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 240
Cdd:COG2319  291 VNSVAFSP-DGKLLASGSDDGtVRLWDLATGKL----------LRTLTGHTgAVRSVAFSPDGKTLASGS-DDGTVRLWD 358

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 291045307 241 VSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQ 284
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 210-313 1.22e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 210 GHT-PVTSLAWAPSGGRLLSASPvDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTC 288
Cdd:cd00200    7 GHTgGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100
                 ....*....|....*....|....*...
gi 291045307 289 ERwpTLSGRCQ---TGCWSPDGsRLLFT 313
Cdd:cd00200   86 VR--TLTGHTSyvsSVAFSPDG-RILSS 110
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 186-326 2.58e-07

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 50.44  E-value: 2.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 186 IWTLDPTSLSTRpssgcaQVLSHPGHtpVTSLAWAPSGGRLL--SASPVDAAIRVWDVSTETCVPLpWFRGGGVTNLLWS 263
Cdd:COG0823   13 IYVVDLDGGEPR------RLTNSPGI--DTSPAWSPDGRRIAftSDRGGGPQIYVVDADGGEPRRL-TFGGGYNASPSWS 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 291045307 264 PDGSKIL-ATTPSAVFRVW--------EAQMWTCERWPTlsgrcqtgcWSPDGSRLLFT--VLGEPLIYSLSFP 326
Cdd:COG0823   84 PDGKRLAfVSRSDGRFDIYvldldggaPRRLTDGPGSPS---------WSPDGRRIVFSsdRGGRPDLYVVDLD 148
WD40 COG2319
WD40 repeat [General function prediction only];
184-311 8.61e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 8.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 184 ILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASpVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWS 263
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGA-GDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 291045307 264 PDGSKILATTPSAVFRVWEAQMWTCERWPT-LSGRCQTGCWSPDGSRLL 311
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLA 136
WD40 COG2319
WD40 repeat [General function prediction only];
163-243 5.09e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291045307 163 VASLAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCAQVLShpGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDV 241
Cdd:COG2319  333 VRSVAFSPDGKTLASGSDDGTVRLWDLA--------TGELLRTLT--GHTgAVTSVAFSPDGRTLASGS-ADGTVRLWDL 401


                 ..
gi 291045307 242 ST 243
Cdd:COG2319  402 AT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 204-240 9.01e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 9.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 291045307   204 QVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 240
Cdd:smart00320   4 LLKTLKGHTgPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
204-240 2.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 291045307  204 QVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 240
Cdd:pfam00400   3 LLKTLEGHTgSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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