|
Name |
Accession |
Description |
Interval |
E-value |
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
47-370 |
0e+00 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 513.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 47 MWRYREFMPVDPSRIVSLDEGGTPFVRCDTIGSELG-IELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGN 125
Cdd:cd01563 1 LWRYRELLPVTEDDIVSLGEGNTPLVRAPRLGERLGgKNLYVKDEGLNPTGSFKDRGMTVAVSKAKELGVKAVACASTGN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 126 TSASLAAYAARAGLGCVVLLPSGKvALGKLAQAMFHGARVLSVRGNFDEALEAVTELALMGELYLLNSVNPFRLEGQKSI 205
Cdd:cd01563 81 TSASLAAYAARAGIKCVVFLPAGK-ALGKLAQALAYGATVLAVEGNFDDALRLVRELAEENWIYLSNSLNPYRLEGQKTI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 206 GFEIVDDLGWESPDRIILPVGNAGNISAIWKGISEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVA 285
Cdd:cd01563 160 AFEIAEQLGWEVPDYVVVPVGNGGNITAIWKGFKELKELGLIDRLPRMVGVQAEGAAPIVRAFKEGKDDIEPVENPETIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 286 TAIRIGAPVSYLKALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTG 365
Cdd:cd01563 240 TAIRIGNPASGPKALRAVRESGGTAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLKKLREEGIIDKGERVVVVLTG 319
|
....*
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 366 HVLKD 370
Cdd:cd01563 320 HGLKD 324
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
3-396 |
1.70e-177 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 499.73 E-value: 1.70e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 3 RCISCGREYDlEEIIYTCRECGSVLEVECDvEVSRDVFRGRRqNMWRYREFMPV-DPSRIVSLDEGGTPFVRCDTIGSEL 81
Cdd:COG0498 3 RCTRCGATFS-DALLYLCPDCGGLLPDSYP-ALSREDLASRR-GLWRYRELLPFdDEEKAVSLGEGGTPLVKAPRLADEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 82 GIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLLPSGKVALGKLAQAMFH 161
Cdd:COG0498 80 GKNLYVKEEGHNPTGSFKDRAMQVAVSLALERGAKTIVCASSGNGSAALAAYAARAGIEVFVFVPEGKVSPGQLAQMLTY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 162 GARVLSVRGNFDEALEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGwESPDRIILPVGNAGNISAIWKGISEF 241
Cdd:COG0498 160 GAHVIAVDGNFDDAQRLVKELAADEGLYAVNSINPARLEGQKTYAFEIAEQLG-RVPDWVVVPTGNGGNILAGYKAFKEL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 242 YRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRdPETVATAIRIGAPVSYLKALRAIYESDGYAESVTDEEILSA 321
Cdd:COG0498 239 KELGLIDRLPRLIAVQATGCNPILTAFETGRDEYEPER-PETIAPSMDIGNPSNGERALFALRESGGTAVAVSDEEILEA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 322 QKLLARREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTGHVLKDPDTAIKAST-EPVEVEPDINQLRSIIR 396
Cdd:COG0498 318 IRLLARREGIFVEPATAVAVAGLRKLREEGEIDPDEPVVVLSTGHGLKFPDAVREALGgEPLAVPPDLEAVKAAVE 393
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
47-372 |
1.08e-168 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 474.95 E-value: 1.08e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 47 MWRYREFMPVDPSRIVSLDEGGTPFVRCDTIGSELGI-ELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGN 125
Cdd:TIGR00260 1 VWRYREFLPVTEKDLVDLGEGVTPLFRAPALAANVGIkNLYVKELGHNPTLSFKDRGMAVALTKALELGNDTVLCASTGN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 126 TSASLAAYAARAGLGCVVLLPSGKVALGKLAQAMFHGARVLSVRGNFDEALEAVTELALMGELYLLNSVN--PFRLEGQK 203
Cdd:TIGR00260 81 TGAAAAAYAGKAGLKVVVLYPAGKISLGKLAQALGYNAEVVAIDGNFDDAQRLVKQLFEDKPALGLNSANsiPYRLEGQK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 204 SIGFEIVDDLGWESPDRIILPVGNAGNISAIWKGISEFYRAGFiDERPMMTGIQAEGASPVVEAFRKGRtEIEPVRDPET 283
Cdd:TIGR00260 161 TYAFEAVEQLGWEAPDKVVVPVPNSGNFGAIWKGFKEKKMLGL-DSLPVKRGIQAEGAADIVRAFLEGG-QWEPIETPET 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 284 VATAIRIGAPVSYLKALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVV 363
Cdd:TIGR00260 239 LSTAMDIGNPANWPRALEAFRRSNGYAEDLSDEEILEAIKLLAREEGYFVEPHSAVAVAALLKLVEKGTADPAERVVCAL 318
|
....*....
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 364 TGHVLKDPD 372
Cdd:TIGR00260 319 TGNGLKDPE 327
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
2-373 |
1.34e-95 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 291.52 E-value: 1.34e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 2 IRCISCGREYDLEEIIYTCrECGSVLEVECDVE-----VSRDVFRGRRQNMWRYREFMPV-DPSRIVSLDEGGTPFVRCD 75
Cdd:PRK08197 8 LECSKCGETYDADQVHNLC-KCGKPLLVRYDLEavkqaVTREALAGRPANLWRYHELLPVrDPEHIVSLGEGMTPLLPLP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 76 TIGSELGI-ELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLLPSGKVALGK 154
Cdd:PRK08197 87 RLGKALGIgRLWVKDEGLNPTGSFKARGLAVGVSRAKELGVKHLAMPTNGNAGAAWAAYAARAGIRATIFMPADAPEITR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 155 LAQAMFhGARVLSVRGNFDEALEAVTELALMGELYLLNSVN-PFRLEGQKSIGFEIVDDLGWESPDRIILPVGNAGNISA 233
Cdd:PRK08197 167 LECALA-GAELYLVDGLISDAGKIVAEAVAEYGWFDVSTLKePYRIEGKKTMGLELAEQLGWRLPDVILYPTGGGVGLIG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 234 IWKGISEFYRAGFID-ERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPVSYLKALRAIYESDGYAES 312
Cdd:PRK08197 246 IWKAFDELEALGWIGgKRPRLVAVQAEGCAPIVKAWEEGKEESEFWEDAHTVAFGIRVPKALGDFLVLDAVRETGGCAIA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 313 VTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTGHVLKDPDT 373
Cdd:PRK08197 326 VSDDAILAAQRELAREEGLFACPEGAATFAAARQLRESGWLKGDERVVLFNTGSGLKYPDT 386
|
|
| PLN02569 |
PLN02569 |
threonine synthase |
4-396 |
4.26e-91 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 282.86 E-value: 4.26e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 4 CISCGREYDLEEIIYTCREcGSVLEVECDVEV--------SRDVFRGR--------RQNMWRYREFM-PV-DPSRIVSLD 65
Cdd:PLN02569 52 CPLTGEKYSLDEVVYRSKS-GGLLDVRHDMEAlkrydgkyWRALFDSRvgkttwpyGSGVWSKKEWVlPEiDDDDIVSLF 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 66 EGGTPFVRCDTIGSE-LGI-ELYVKVEGSNPTGSFKDRGMSVGITKALELG-----VDTVGCASTGNTSASLAAYAARAG 138
Cdd:PLN02569 131 EGNSNLFWAERLGKEfLGMnDLWVKHCGISHTGSFKDLGMTVLVSQVNRLRkmakpVVGVGCASTGDTSAALSAYCAAAG 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 139 LGCVVLLPSGKVALGKLAQAMFHGARVLSVRGNFDEALEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGWESP 218
Cdd:PLN02569 211 IPSIVFLPADKISIAQLVQPIANGALVLSIDTDFDGCMRLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFDWEVP 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 219 DRIILPVGNAGNISAIWKGISEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPVSYLK 298
Cdd:PLN02569 291 DWVIVPGGNLGNIYAFYKGFKMCKELGLVDRLPRLVCAQAANANPLYRAYKSGWEEFKPVKANPTFASAIQIGDPVSIDR 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 299 ALRAIYESDGYAESVTDEEILSAQKlLARREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTGHVLK--------- 369
Cdd:PLN02569 371 AVYALKESNGIVEEATEEELMDAQA-EADKTGMFLCPHTGVALAALKKLRASGVIGPTDRTVVVSTAHGLKftqskidyh 449
|
410 420 430
....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 370 ---DPDTAIKASTEPVEVEPDINQLRSIIR 396
Cdd:PLN02569 450 skeIPDMACRFANPPVSVKADFGSVMDVLK 479
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
1-371 |
7.87e-78 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 247.42 E-value: 7.87e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 1 MIRCISCGREYDlEEIIYTCrECGSVLEVECDVE-VSRDVFRGRRQNMWRYREFMPvDPSRIVSLDEGGTPFVRCDtIGS 79
Cdd:PRK05638 1 KMKCPKCGREYN-SYIPPFC-ICGELLEIIYDYSsVDVRKWKNRDPGVWRYKELLP-QVKKIISLGEGGTPLIRAR-ISE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 80 ELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLLPSgKVALGKLAQAM 159
Cdd:PRK05638 77 KLGENVYIKDETRNPTGSFRDRLATVAVSYGLPYAANGFIVASDGNAAASVAAYSARAGKEAFVVVPR-KVDKGKLIQMI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 160 FHGARVLSVRGNFDEALEAVTELALMGELYLLNSV-NPFRLEGQKSIGFEIVDDLGwesPDRIILPVGNAGNISAIWKGI 238
Cdd:PRK05638 156 AFGAKIIRYGESVDEAIEYAEELARLNGLYNVTPEyNIIGLEGQKTIAFELWEEIN---PTHVIVPTGSGSYLYSIYKGF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 239 SEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEpvrdpETVATAIRIGAPVSYLKALRAIYESDGYAESVTDEEI 318
Cdd:PRK05638 233 KELLEIGVIEEIPKLIAVQTERCNPIASEILGNKTKCN-----ETKALGLYVKNPVMKEYVSEAIKESGGTAVVVNEEEI 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 319 LSAQKLLArREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTGHVLKDP 371
Cdd:PRK05638 308 MAGEKLLA-KEGIFAELSSAVVMPALLKLGEEGYIEKGDKVVLVVTGSGLKGY 359
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
62-365 |
2.32e-74 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 233.36 E-value: 2.32e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 62 VSLDEGGTPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALE-LGVDTVGCASTGNTSASLAAYAARAGLG 140
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEgEGGKTVVEASSGNHGRALAAAAARLGLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 141 CVVLLPSGKVAlGKLAQAMFHGARVLSVRGNFDEALEAVTELALMGE--LYLLNSVNPFRLEGQKSIGFEIVDDLGwESP 218
Cdd:pfam00291 81 VTIVVPEDAPP-GKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPgaYYINQYDNPLNIEGYGTIGLEILEQLG-GDP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 219 DRIILPVGNAGNISAIWKGisefYRAGFIDERpmMTGIQAEGASPVVEAFRKGRTEIEPVrdPETVATAIRIGAPVSYLk 298
Cdd:pfam00291 159 DAVVVPVGGGGLIAGIARG----LKELGPDVR--VIGVEPEGAPALARSLAAGRPVPVPV--ADTIADGLGVGDEPGAL- 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 299 ALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLiKLVDEGVVDRGERVVCVVTG 365
Cdd:pfam00291 230 ALDLLDEYVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAAL-KLALAGELKGGDRVVVVLTG 295
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
69-366 |
2.49e-65 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 208.52 E-value: 2.49e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALELG---VDTVGCASTGNTSASLAAYAARAGLGCVVLL 145
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGklpKGVIIESTGGNTGIALAAAAARLGLKCTIVM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 146 PSGKvALGKLAQAMFHGARVLSVRGNFDEALEAVTELALMGE-LYLLNS-VNPFRLEGQKSIGFEIVDDLGWESPDRIIL 223
Cdd:cd00640 81 PEGA-SPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEDPgAYYVNQfDNPANIAGQGTIGLEILEQLGGQKPDAVVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 224 PVGNAGNISAIWKGISEFYragfidERPMMTGIQAEgaspvveafrkgrteiepvrdpetvatairigapvsylkalrai 303
Cdd:cd00640 160 PVGGGGNIAGIARALKELL------PNVKVIGVEPE-------------------------------------------- 189
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 304 yesdgyAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGvvDRGERVVCVVTGH 366
Cdd:cd00640 190 ------VVTVSDEEALEAIRLLAREEGILVEPSSAAALAAALKLAKKL--GKGKTVVVILTGG 244
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
67-365 |
1.78e-56 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 187.99 E-value: 1.78e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 67 GGTPFVRCDTIGSELGI-ELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLL 145
Cdd:PRK06381 14 GGTPLLRARKLEEELGLrKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGYSGITVGTCGNYGASIAYFARLYGLKAVIFI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 146 PSGkVALGKLAQAMFHGARVLSVRGNFDEALEAVTELALMGELYLLN--SVNP-FRLEGQKSIGFEIVDDLGwESPDRII 222
Cdd:PRK06381 94 PRS-YSNSRVKEMEKYGAEIIYVDGKYEEAVERSRKFAKENGIYDANpgSVNSvVDIEAYSAIAYEIYEALG-DVPDAVA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 223 LPVGNAGNISAIWKGISEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRigAP-VSYL---- 297
Cdd:PRK06381 172 VPVGNGTTLAGIYHGFRRLYDRGKTSRMPRMIGVSTSGGNQIVESFKRGSSEVVDLEVDEIRETAVN--EPlVSYRsfdg 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 298 -KALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDrgERVVCVVTG 365
Cdd:PRK06381 250 dNALEAIYDSHGYAFGFSDDEMVKYAELLRRMEGLNALPASASALAALVKYLKKNGVN--DNVVAVITG 316
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
1-369 |
8.00e-52 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 176.94 E-value: 8.00e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 1 MIRCISCGREYDlEEIIYTCrECGSVLevecDVEVSRDVFRGRRQ--NMWRYREFMPVDPSRIVSLDEGGTPFVrcdtig 78
Cdd:PRK08329 1 MLRCTKCGRTYE-EKFKLRC-DCGGTL----LVEREYGSFDSPREylDMRRYIDYLPVDEEFLPHLTPPITPTV------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 79 sELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLLPSgKVALGKLAQA 158
Cdd:PRK08329 69 -KRSIKVYFKLDYLQPTGSFKDRGTYVTVAKLKEEGINEVVIDSSGNAALSLALYSLSEGIKVHVFVSY-NASKEKISLL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 159 MFHGARVLSVRGNFDEA-LEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGweSPDRIILPVGNAGNISAIWKG 237
Cdd:PRK08329 147 SRLGAELHFVEGDRMEVhEEAVKFSKRNNIPYVSHWLNPYFLEGTKTIAYEIYEQIG--VPDYAFVPVGSGTLFLGIWKG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 238 ISEFYRAGFIDERPMMTGIQAEGASPVVEafrkgRTEIEpvrdpETVATAIRIGAPVSYLKALRAIYESDGYAESVTDEE 317
Cdd:PRK08329 225 FKELHEMGEISKMPKLVAVQAEGYESLCK-----RSKSE-----NKLADGIAIPEPPRKEEMLRALEESNGFCISVGEEE 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 318 ILSAQKLLaRREGIGVEPASAASIAGLIKLVDEGVVDRGERVVCVVTGHVLK 369
Cdd:PRK08329 295 TRAALHWL-RRMGFLVEPTSAVALAAYWKLLEEGLIEGGSKVLLPLSGSGLK 345
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
2-369 |
6.52e-47 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 163.75 E-value: 6.52e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 2 IRCISCGREY-DLEEIiyTCRECGSVLEVECDVEVSRDVfrgRRQNMWRYREFmpvdpsriVSLDEGGTPFVRcdtigse 80
Cdd:PRK06450 4 EVCMKCGKEReSIYEI--RCKKCGGPFEILIDFEFDKNL---ERKNFPYIKHF--------ISLGEGRTPLIK------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 81 lGIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVGCASTGNTSASLAAYAARAGLGCVVLLPSgKVALGKLAQAMF 160
Cdd:PRK06450 64 -KGNIWFKLDFLNPTGSYKDRGSVTLISYLAEKGIKQISEDSSGNAGASIAAYGAAAGIEVKIFVPE-TASGGKLKQIES 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 161 HGARVLSVRGNFDEALEAVTElalMGELYLLNSVNP-FRlEGQKSIGFEIVDDLGWESPDRIILPVGNAGNISAIWKGIS 239
Cdd:PRK06450 142 YGAEVVRVRGSREDVAKAAEN---SGYYYASHVLQPqFR-DGIRTLAYEIAKDLDWKIPNYVFIPVSAGTLLLGVYSGFK 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 240 EFYRAGFIDERPMMTGIQAEGASPVVEAFRKgrTEIEPVRDPETVATAIRIGAPVSYLKALRAIYESdGYAESVTDEEIL 319
Cdd:PRK06450 218 HLLDSGVISEMPKIVAVQTEQVSPLCAKFKG--ISYTPPDKVTSIADALVSTRPFLLDYMVKALSEY-GECIVVSDNEIV 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 320 SAQKLLARReGIGVEPASAASIAGLIKLvdegvvdRGERVVCVVTGHVLK 369
Cdd:PRK06450 295 EAWKELAKK-GLLVEYSSATVYAAYKKY-------SVNDSVLVLTGSGLK 336
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
69-365 |
1.38e-31 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 122.07 E-value: 1.38e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKAL-ELGVDTVGCASTGNtsaslaayaarAGLG------- 140
Cdd:COG1171 25 TPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASLSeEERARGVVAASAGN-----------HAQGvayaarl 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 141 ----CVVLLPSGkVALGKLAQAMFHGARVLSVRGNFDEALEAVTELALMGELYLlnsVNPFR----LEGQKSIGFEIVDD 212
Cdd:COG1171 94 lgipATIVMPET-APAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATF---VHPFDdpdvIAGQGTIALEILEQ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 213 LGweSPDRIILPVGNAGNISaiwkGISEFYRAgfIDERPMMTGIQAEGASPVVEAFRKGRteIEPVRDPETVATAIRIGA 292
Cdd:COG1171 170 LP--DLDAVFVPVGGGGLIA----GVAAALKA--LSPDIRVIGVEPEGAAAMYRSLAAGE--PVTLPGVDTIADGLAVGR 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 293 PVSY-LKALRAiYESDGYaeSVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGvvdRGERVVCVVTG 365
Cdd:COG1171 240 PGELtFEILRD-LVDDIV--TVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKERL---KGKRVVVVLSG 307
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
69-365 |
1.47e-29 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 116.05 E-value: 1.47e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALE----LGVdtVgCASTGNTSASLAAYAARAGLGCVVL 144
Cdd:cd01562 18 TPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSLSEeeraKGV--V-AASAGNHAQGVAYAAKLLGIPATIV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 145 LPSGKVALgKLAQAMFHGARVLSVRGNFDEALEAVTELALMGELYLlnsVNPFR----LEGQKSIGFEIVDDLGweSPDR 220
Cdd:cd01562 95 MPETAPAA-KVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTF---IHPFDdpdvIAGQGTIGLEILEQVP--DLDA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 221 IILPVGNAGNISaiwkGISEFYRAGFIDERpmMTGIQAEGASPVVEAFRKGrtEIEPVRDPETVATAIRIGAPVSYLKAL 300
Cdd:cd01562 169 VFVPVGGGGLIA----GIATAVKALSPNTK--VIGVEPEGAPAMAQSLAAG--KPVTLPEVDTIADGLAVKRPGELTFEI 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 301 RAIYESDGYaeSVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEgvvDRGERVVCVVTG 365
Cdd:cd01562 241 IRKLVDDVV--TVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLD---LKGKKVVVVLSG 300
|
|
| L-Ser-dehyd |
cd06448 |
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
69-363 |
3.18e-18 |
|
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Pssm-ID: 107209 Cd Length: 316 Bit Score: 84.66 E-value: 3.18e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDT---VGCASTGNTSASLAAYAARAGLGCVVLL 145
Cdd:cd06448 2 TPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGLNEcvhVVCSSGGNAGLAAAYAARKLGVPCTIVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 146 P--SGKVALGKLAQAmfhGARVLSVRGNFDEALEAVTElALMGELYLLNSVNPFR----LEGQKSIGFEIVDDLG-WESP 218
Cdd:cd06448 82 PesTKPRVVEKLRDE---GATVVVHGKVWWEADNYLRE-ELAENDPGPVYVHPFDdpliWEGHSSMVDEIAQQLQsQEKV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 219 DRIILPVGNAGNISAIWKGISefyRAGFIDerPMMTGIQAEGASPVVEAFRKGrteiEPVRDPETVATAIRIGAPVSYLK 298
Cdd:cd06448 158 DAIVCSVGGGGLLNGIVQGLE---RNGWGD--IPVVAVETEGAHSLNASLKAG----KLVTLPKITSVATSLGAKTVSSQ 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 299 ALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIA----GLIKLVDEGVVDRGERVVCVV 363
Cdd:cd06448 229 ALEYAQEHNIKSEVVSDRDAVQACLRFADDERILVEPACGAALAvvysGKILDLQLEVLLTPLDNVVVV 297
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
67-376 |
7.26e-18 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 83.33 E-value: 7.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 67 GGTPFVRCDTIGSELGIELYVKVEGSNPTGSFKDR---GMsvgITKALELGV----DTVGCASTGNTSASLAAYAARAGL 139
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRialYM---IEDAEKRGLlkpgTTIIEPTSGNTGIGLAMVAAAKGY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 140 GCVVLLPSgKVALGKLAQAMFHGARVLSVRGNFDEALEA----VTELALMGELYLL-----NSVNPfrLEGQKSIGFEIV 210
Cdd:cd01561 78 RFIIVMPE-TMSEEKRKLLRALGAEVILTPEAEADGMKGaiakARELAAETPNAFWlnqfeNPANP--EAHYETTAPEIW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 211 DDLGwESPDRIILPVGNAGNISaiwkGISEFYRAGFIDERPmmTGIQAEGaSPVVEAFRKGRTEIE---PVRDPETVATA 287
Cdd:cd01561 155 EQLD-GKVDAFVAGVGTGGTIT----GVARYLKEKNPNVRI--VGVDPVG-SVLFSGGPPGPHKIEgigAGFIPENLDRS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 288 IrigapvsylkalraIYEsdgyAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEgvVDRGERVVCVVtghv 367
Cdd:cd01561 227 L--------------IDE----VVRVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKLAKR--LGPGKTIVTIL---- 282
|
....*....
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 368 lkdPDTAIK 376
Cdd:cd01561 283 ---PDSGER 288
|
|
| PRK08638 |
PRK08638 |
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB; |
69-365 |
1.96e-16 |
|
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
Pssm-ID: 236317 [Multi-domain] Cd Length: 333 Bit Score: 79.78 E-value: 1.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRG----MSVGITKALELGVDTvgcASTGNTSASLAAYAARAGLGCVVL 144
Cdd:PRK08638 28 TPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGafnkLSSLTDAEKRKGVVA---CSAGNHAQGVALSCALLGIDGKVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 145 LPSGkVALGKLAQAMFHGARVLSVRGNFDEALEAVTELALM-GELYLLNSVNPFRLEGQKSIGFEIVDDLgWESpDRIIL 223
Cdd:PRK08638 105 MPKG-APKSKVAATCGYGAEVVLHGDNFNDTIAKVEEIVEEeGRTFIPPYDDPKVIAGQGTIGLEILEDL-WDV-DTVIV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 224 PVGNAGNISAIWKGISEFyragfideRPMMT--GIQAEGASPVVEAFRKGrtEIEPVRDPETVA--TAIRIGAPVSYLKA 299
Cdd:PRK08638 182 PIGGGGLIAGIAVALKSI--------NPTIHiiGVQSENVHGMAASFYAG--EITTHRTTGTLAdgCDVSRPGNLTYEIV 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 300 LRAIYEsdgyAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIklvdEGVVDR---GERVVCVVTG 365
Cdd:PRK08638 252 RELVDD----IVLVSEDEIRNAMKDLIQRNKVVTEGAGALATAALL----SGKLDQyiqNKKVVAIISG 312
|
|
| PRK08639 |
PRK08639 |
threonine dehydratase; Validated |
69-365 |
5.35e-16 |
|
threonine dehydratase; Validated
Pssm-ID: 236318 [Multi-domain] Cd Length: 420 Bit Score: 79.08 E-value: 5.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRG----MSVGITKALELGVdtVgCASTGNTSASLAAYAARAGLGCVVL 144
Cdd:PRK08639 26 TPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGaynaISQLSDEELAAGV--V-CASAGNHAQGVAYACRHLGIPGVIF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 145 LPSgKVALGKLAQAMFHGARVLSVR--G-NFDEALEAVTELALMGELYLlnsVNPFR----LEGQKSIGFEIVDDLGWE- 216
Cdd:PRK08639 103 MPV-TTPQQKIDQVRFFGGEFVEIVlvGdTFDDSAAAAQEYAEETGATF---IPPFDdpdvIAGQGTVAVEILEQLEKEg 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 217 SPDRIILPVGNAGNISaiwkGISEFYRAGFIDERpmMTGIQAEGASPVVEAFRKGR----TEIEPVRDPETVAtaiRIGA 292
Cdd:PRK08639 179 SPDYVFVPVGGGGLIS----GVTTYLKERSPKTK--IIGVEPAGAASMKAALEAGKpvtlEKIDKFVDGAAVA---RVGD 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 293 pVSYlKALRAiyesdgYAESVT--DE-----EILSaqklLARREGIGVEPASAASIAGLIKLVDEgvvDRGERVVCVVTG 365
Cdd:PRK08639 250 -LTF-EILKD------VVDDVVlvPEgavctTILE----LYNKEGIVAEPAGALSIAALELYKDE---IKGKTVVCVISG 314
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
67-373 |
3.10e-15 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 75.47 E-value: 3.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 67 GGTPFVRCDTIGSELGIELYVKVEGSNPTGSFKDR---GMsvgITKALELGV----DTVGCASTGNTsaslaayaaraGL 139
Cdd:COG0031 12 GNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRialSM---IEDAEKRGLlkpgGTIVEATSGNT-----------GI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 140 G-----------CVVLLPSgKVALGKLAQAMFHGARVLSVRG--NFDEALEAVTELAL-MGELYLLN-SVNPFRLEG-QK 203
Cdd:COG0031 78 GlamvaaakgyrLILVMPE-TMSKERRALLRAYGAEVVLTPGaeGMKGAIDKAEELAAeTPGAFWPNqFENPANPEAhYE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 204 SIGFEIVDDLGwESPDRIILPVGNAGNISaiwkGISEFYRAgfidERPMMT--GIQAEGaSPVVEAFRKGRTEIEpvrdp 281
Cdd:COG0031 157 TTGPEIWEQTD-GKVDAFVAGVGTGGTIT----GVGRYLKE----RNPDIKivAVEPEG-SPLLSGGEPGPHKIE----- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 282 etvataiRIGAPVsylkaLRAIYESDGY--AESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEgvVDRGERV 359
Cdd:COG0031 222 -------GIGAGF-----VPKILDPSLIdeVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR--LGPGKTI 287
|
330
....*....|....
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 360 VCVVtghvlkdPDT 373
Cdd:COG0031 288 VTIL-------PDS 294
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
69-365 |
9.79e-15 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 74.22 E-value: 9.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGiELYVKVEGSNPTGSFKDRGMsvgITKALELGVDTVG--CASTGNTSASLAAYAARAGLGCVVLLP 146
Cdd:PRK08246 24 TPVLEADGAGFGPA-PVWLKLEHLQHTGSFKARGA---FNRLLAAPVPAAGvvAASGGNAGLAVAYAAAALGVPATVFVP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 147 --SGKVALGKLAQamfHGARVLSVRGNFDEALEAVTELAL-MGELYLLNSVNPFRLEGQKSIGFEIVDDLGweSPDRIIL 223
Cdd:PRK08246 100 etAPPAKVARLRA---LGAEVVVVGAEYADALEAAQAFAAeTGALLCHAYDQPEVLAGAGTLGLEIEEQAP--GVDTVLV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 224 PVGNAGNISAIwkgisefyrAGFIDERPMMTGIQAEGASPVVEAFRKGrteiEPVR-DPETVAT----AIRIGApvsylK 298
Cdd:PRK08246 175 AVGGGGLIAGI---------AAWFEGRARVVAVEPEGAPTLHAALAAG----EPVDvPVSGIAAdslgARRVGE-----I 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 299 ALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLikLVDEGVVDRGERVVCVVTG 365
Cdd:PRK08246 237 AFALARAHVVTSVLVSDEAIIAARRALWEELRLAVEPGAATALAAL--LSGAYVPAPGERVAVVLCG 301
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
69-365 |
3.97e-14 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 72.42 E-value: 3.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGI----TKALELGVDTvgcASTGNTSASLAAYAARAGLGCVVL 144
Cdd:PRK06815 21 TPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLrllnEAQRQQGVIT---ASSGNHGQGVALAAKLAGIPVTVY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 145 LPSGKVALgKLAQAMFHGARVLSVRGNFDEA-LEAVTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGweSPDRIIL 223
Cdd:PRK06815 98 APEQASAI-KLDAIRALGAEVRLYGGDALNAeLAARRAAEQQGKVYISPYNDPQVIAGQGTIGMELVEQQP--DLDAVFV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 224 PVGNAGNISaiwkGISEFYRAgfiderpMMTGIQAEGASP-----VVEAFRKGrtEIEPVRDPETVA--TA--IRIGApV 294
Cdd:PRK06815 175 AVGGGGLIS----GIATYLKT-------LSPKTEIIGCWPanspsLYTSLEAG--EIVEVAEQPTLSdgTAggVEPGA-I 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 295 SYLKALRAIYESdgyaESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGvvdRGERVVCVVTG 365
Cdd:PRK06815 241 TFPLCQQLIDQK----VLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKLAPRY---QGKKVAVVLCG 304
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
85-365 |
2.36e-12 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 67.73 E-value: 2.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 85 LYVKVEGSNPTGSFKDRGMSVGITKALELGVD-TVGCASTGNTSASLAAYAARAGLGCVVLLPSGKVALgKLAQAMFHGA 163
Cdd:PRK08813 50 VWLKLENLQRTGSYKVRGALNALLAGLERGDErPVICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQT-KIAGVAHWGA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 164 RVLSVRGNFDEALEAVTELALMGELYLLNSV-NPFRLEGQKSIGFEivddLGWESPDRIILPVGNAGNISaiwkGISEFY 242
Cdd:PRK08813 129 TVRQHGNSYDEAYAFARELADQNGYRFLSAFdDPDVIAGQGTVGIE----LAAHAPDVVIVPIGGGGLAS----GVALAL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 243 RAGFIderpMMTGIQAEGASPVVEAFRKGRTEIEPVrdpETVATAIRIGAPVSYLKALRAIYESDgyAESVTDEEILSAQ 322
Cdd:PRK08813 201 KSQGV----RVVGAQVEGVDSMARAIRGDLREIAPV---ATLADGVKVKIPGFLTRRLCSSLLDD--VVIVREAELRETL 271
|
250 260 270 280
....*....|....*....|....*....|....*....|...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 323 KLLARREGIGVEPASAASIAGliklvdeGVVDRGERVVCVVTG 365
Cdd:PRK08813 272 VRLALEEHVIAEGAGALALAA-------GRRVSGKRKCAVVSG 307
|
|
| Trp-synth_B |
cd06446 |
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the ... |
69-373 |
1.87e-09 |
|
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.
Pssm-ID: 107207 Cd Length: 365 Bit Score: 58.70 E-value: 1.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSEL-GIELYVKVEGSNPTGSFKdrgmsvgITKAL-------ELGVDTVgCASTG------NTSASLAAYa 134
Cdd:cd06446 35 TPLYRAKRLSEYLgGAKIYLKREDLNHTGAHK-------INNALgqallakRMGKKRV-IAETGagqhgvATATACALF- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 135 araGLGCVVLLpsgkVALGKLAQAM------FHGARVLSVRGNF-------DEALE-AVTELAlmGELYLLNSV---NPF 197
Cdd:cd06446 106 ---GLECEIYM----GAVDVERQPLnvfrmeLLGAEVVPVPSGSgtlkdaiSEAIRdWVTNVE--DTHYLLGSVvgpHPY 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 198 R---LEGQKSIGFEI---VDDLGWESPDRIILPVG---NAGNIsaiwkgiseFYraGFI-DERPMMTGIQAEGA---SPV 264
Cdd:cd06446 177 PnmvRDFQSVIGEEAkkqILEKEGELPDVVIACVGggsNAAGL---------FY--PFInDKDVKLIGVEAGGCgleTGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 265 VEA-FRKGRTEIEP-------------VRDPETVATAIR---IGAPVSYLKALraiyesdGYAE--SVTDEEILSAQKLL 325
Cdd:cd06446 246 HAAyLFGGTAGVLHglkmytlqdedgqIVPPHSISAGLDypgVGPEHAYLKDS-------GRVEyvAVTDEEALEAFKLL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 326 ARREGIGVEPASAASIAGLIKLVDEGvvDRGERVVCVVTGHVLKDPDT 373
Cdd:cd06446 319 ARTEGIIPALESSHAIAYAIKLAKKL--GKEKVIVVNLSGRGDKDLQT 364
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
69-232 |
2.24e-09 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 58.24 E-value: 2.24e-09
|
| eutB |
PRK07476 |
threonine dehydratase; Provisional |
69-365 |
1.50e-08 |
|
threonine dehydratase; Provisional
Pssm-ID: 236025 [Multi-domain] Cd Length: 322 Bit Score: 55.74 E-value: 1.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITK----ALELGVDTvgcASTGNTSASLAAYAARAGLGCVV- 143
Cdd:PRK07476 20 TPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALLSlsaqERARGVVT---ASTGNHGRALAYAARALGIRATIc 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 144 ---LLPSGKVAlgklAQAMfHGARVLSVRGNFDEALEAVTELAlmgELYLLNSVNPFR----LEGQKSIGFEIVDDLgwE 216
Cdd:PRK07476 97 msrLVPANKVD----AIRA-LGAEVRIVGRSQDDAQAEVERLV---REEGLTMVPPFDdpriIAGQGTIGLEILEAL--P 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 217 SPDRIILPV---GNAGNISAIWKGISEFYRagfiderpmMTGIQAEGASPVVEAFRKGRteiePVRDPE--TVATAIR-- 289
Cdd:PRK07476 167 DVATVLVPLsggGLASGVAAAVKAIRPAIR---------VIGVSMERGAAMHASLAAGR----PVQVEEvpTLADSLGgg 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 290 IGAPVSY-LKALRAIYESdgyAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIklvDEGVVDRGERVVCVVTG 365
Cdd:PRK07476 234 IGLDNRYtFAMCRALLDD---VVLLDEAEIAAGIRHAYREERLVVEGAGAVGIAALL---AGKIAARDGPIVVVVSG 304
|
|
| PLN02970 |
PLN02970 |
serine racemase |
69-343 |
4.89e-08 |
|
serine racemase
Pssm-ID: 215524 [Multi-domain] Cd Length: 328 Bit Score: 54.30 E-value: 4.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKA----LELGVDTvgcASTGNTSASLAAYAARAGLGCVVL 144
Cdd:PLN02970 28 TPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLsddqAEKGVVT---HSSGNHAAALALAAKLRGIPAYIV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 145 LPSGKVALGKLAQAMFHGARVLSVRGNfdEALEAVTE--LALMGELYLLNSVNPFRLEGQKSIGFEIVDDLgwESPDRII 222
Cdd:PLN02970 105 VPKNAPACKVDAVIRYGGIITWCEPTV--ESREAVAArvQQETGAVLIHPYNDGRVISGQGTIALEFLEQV--PELDVII 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 223 LPVGNAGNISAI---WKGISefyragfiderPMMTGIQAE--GASPVVEAFRKGrtEIEPVRDPETVATAIR--IGA--- 292
Cdd:PLN02970 181 VPISGGGLISGIalaAKAIK-----------PSIKIIAAEpkGADDAAQSKAAG--EIITLPVTNTIADGLRasLGDltw 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 293 PVSYLKALRAIyesdgyaeSVTDEEILSAQKLLARREGIGVEPASAASIAG 343
Cdd:PLN02970 248 PVVRDLVDDVI--------TVDDKEIIEAMKLCYERLKVVVEPSGAIGLAA 290
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
69-365 |
1.00e-07 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 53.07 E-value: 1.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTVG--CASTGNTSASLAAYAARAGLGCVVLLP 146
Cdd:PRK06110 22 TPQYRWPLLAERLGCEVWVKHENHTPTGAFKVRGGLVYFDRLARRGPRVRGviSATRGNHGQSVAFAARRHGLAATIVVP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 147 SGKvALGKLAQAMFHGARVLSVRGNFDEALEAVTELALMGELYLLNSVNPFRLEGQKSIG---FEIVDDLgwespDRIIL 223
Cdd:PRK06110 102 HGN-SVEKNAAMRALGAELIEHGEDFQAAREEAARLAAERGLHMVPSFHPDLVRGVATYAlelFRAVPDL-----DVVYV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 224 PVGNAGNIsaiwkgisefyrAGFIDERPMM------TGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPvsyl 297
Cdd:PRK06110 176 PIGMGSGI------------CGAIAARDALglktriVGVVSAHAPAYALSFEAGRVVTTPVATTLADGMACRTPDP---- 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 298 KALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEgvvDRGERVVCVVTG 365
Cdd:PRK06110 240 EALEVIRAGADRIVRVTDDEVAAAMRAYFTDTHNVAEGAGAAALAAALQERER---LAGKRVGLVLSG 304
|
|
| PRK07334 |
PRK07334 |
threonine dehydratase; Provisional |
69-365 |
3.08e-07 |
|
threonine dehydratase; Provisional
Pssm-ID: 235994 [Multi-domain] Cd Length: 403 Bit Score: 52.20 E-value: 3.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGmsvGITKALELGVDT----VGCASTGNTSASLAAYAARAGLGCVVL 144
Cdd:PRK07334 24 TPCVHSRTLSQITGAEVWLKFENLQFTASFKERG---ALNKLLLLTEEErargVIAMSAGNHAQGVAYHAQRLGIPATIV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 145 LPSGKVALgKLAQAMFHGARVLSVRGNFDEALEAVTELALMGELYLlnsVNPFRLE----GQKSIGFEIVDDLGweSPDR 220
Cdd:PRK07334 101 MPRFTPTV-KVERTRGFGAEVVLHGETLDEARAHARELAEEEGLTF---VHPYDDPaviaGQGTVALEMLEDAP--DLDT 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 221 IILPVGNAGNISaiwkGISEFYRAgfIDERPMMTGIQAEgASPVVEAFRKGRteiEPVRDPETVATAIRIGAPVSYLKAL 300
Cdd:PRK07334 175 LVVPIGGGGLIS----GMATAAKA--LKPDIEIIGVQTE-LYPSMYAAIKGV---ALPCGGSTIAEGIAVKQPGQLTLEI 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 301 RAIYESDgyAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGvvdRGERVVCVVTG 365
Cdd:PRK07334 245 VRRLVDD--ILLVSEADIEQAVSLLLEIEKTVVEGAGAAGLAALLAYPERF---RGRKVGLVLSG 304
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
67-126 |
4.02e-07 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 51.03 E-value: 4.02e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 67 GGTPFVRCDTIGSELGIELYVKVEGSNPTGSFKDR---GMsvgITKALELGV----DTVGCASTGNT 126
Cdd:PRK11761 11 GNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRpalSM---IVQAEKRGEikpgDTLIEATSGNT 74
|
|
| PRK07048 |
PRK07048 |
threo-3-hydroxy-L-aspartate ammonia-lyase; |
69-365 |
1.69e-06 |
|
threo-3-hydroxy-L-aspartate ammonia-lyase;
Pssm-ID: 235918 [Multi-domain] Cd Length: 321 Bit Score: 49.25 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKDRGMSVGITK----ALELGVDTVgcaSTGNTSASLAAYAARAGLGCVVL 144
Cdd:PRK07048 25 TPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQfspeQRRAGVVTF---SSGNHAQAIALSARLLGIPATIV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 145 LPSGKVALgKLAQAMFHGARVLSvrgnFD---EALEAVT-ELALMGELYLLNSVN-PFRLEGQKSIGFEIVDDLGweSPD 219
Cdd:PRK07048 102 MPQDAPAA-KVAATRGYGGEVVT----YDrytEDREEIGrRLAEERGLTLIPPYDhPHVIAGQGTAAKELFEEVG--PLD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 220 RIILPVGNAGNISaiwkGISEFYRAgfIDERPMMTGIQAEGASPVVEAFRKGrtEIEPVRDPETVATairiGAPVSYLKA 299
Cdd:PRK07048 175 ALFVCLGGGGLLS----GCALAARA--LSPGCKVYGVEPEAGNDGQQSFRSG--EIVHIDTPRTIAD----GAQTQHLGN 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 300 LR--AIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGvvdRGERVVCVVTG 365
Cdd:PRK07048 243 YTfpIIRRLVDDIVTVSDAELVDAMRFFAERMKIVVEPTGCLGAAAALRGKVPL---KGKRVGVIISG 307
|
|
| PRK03910 |
PRK03910 |
D-cysteine desulfhydrase; Validated |
138-365 |
5.51e-06 |
|
D-cysteine desulfhydrase; Validated
Pssm-ID: 179673 Cd Length: 331 Bit Score: 47.90 E-value: 5.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 138 GLGCVVLL------------PSGKVALGKLaqamfHGARV--LSVRGNFDEALEAV-TELALMGElyllnsvNPFRLEGQ 202
Cdd:PRK03910 89 GLKCVLLLenpvpteaenylANGNVLLDDL-----FGAEIhvVPAGTDMDAQLEELaEELRAQGR-------RPYVIPVG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 203 KS--IG--------FEIVD--DLGWESPDRIILPVGNAGNIsaiwkgisefyrAGFIderpmmTGIQAEGASPVVEAF-- 268
Cdd:PRK03910 157 GSnaLGalgyvacaLEIAQqlAEGGVDFDAVVVASGSGGTH------------AGLA------AGLAALGPDIPVIGVtv 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 269 RKGRTEIEP-VRDPeTVATAIRIGAPVSYLKA-LRAI--YESDGYAESvTDEEiLSAQKLLARREGIGVEPA-SAASIAG 343
Cdd:PRK03910 219 SRSAAEQEPkVAKL-AQATAELLGLPTEIPRAdIRLWddYVGPGYGVP-TDEM-LEAVKLLARTEGILLDPVyTGKAMAG 295
|
250 260
....*....|....*....|..
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 344 LIKLVDEGVVDRGERVVCVVTG 365
Cdd:PRK03910 296 LIDLIRQGRFKKGGNVLFIHTG 317
|
|
| Thr-synth_2 |
cd01560 |
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of ... |
94-387 |
6.89e-06 |
|
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, archaebacteria and eubacterial groups. This CD, Thr-synth_2, includes enzymes from fungi and eubacterial groups, as well as, metazoan threonine synthase-like proteins.
Pssm-ID: 107203 [Multi-domain] Cd Length: 460 Bit Score: 48.00 E-value: 6.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 94 PTGSFKDRGMSVgITKALE--LGVD----TVGCASTGNT-SASLAAYAARAGLGCVVLLPSGKVALGKLAQAMFHGA--- 163
Cdd:cd01560 106 PTLAFKDMALQF-LGRLLEyfLKRRneriTILVATSGDTgSAAIEGFRGKPNVDVVVLYPKGGVSPIQELQMTTLPAdnv 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 164 RVLSVRGNFDEALEAVTEL----------ALMGelylLNSVNPFRLEGQKSIGFEIVDDLGWESPDR---IILPVGNAGN 230
Cdd:cd01560 185 HVVAVEGDFDDCQSLVKALfadedfnkklKLSS----ANSINWARILAQIVYYFYAYLQLLKRGEGEkveFSVPTGNFGN 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 231 ISaiwkgisefyrAGFIDER---PMMTGIQAEGASPVV-EAFRKGRTEiepvRDPETVAT---AIRIGAPVSYLKALRAI 303
Cdd:cd01560 261 IL-----------AGYYAKKmglPIKKLIVATNENDVLrRFFKTGRYD----RRESLKQTlspAMDILKSSNFERLLFLL 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 304 YESDG------------------------------YAESVTDEEILSAQKLLARREGIGVEPASAasIAglIKLVDEGVV 353
Cdd:cd01560 326 AGRDRtkvkmlmeefeatgflslpkeelkklredfSSGSVSDEETLETIREVYEETGYLIDPHTA--VG--VRAAERVRK 401
|
330 340 350
....*....|....*....|....*....|....
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 354 DRGERVVCVVTGHVLKDPDTAIKASTEPVEVEPD 387
Cdd:cd01560 402 SPGTPGVVLSTAHPAKFPEAVKEALGEEPVELPE 435
|
|
| PRK04346 |
PRK04346 |
tryptophan synthase subunit beta; Validated |
295-377 |
8.47e-06 |
|
tryptophan synthase subunit beta; Validated
Pssm-ID: 235288 Cd Length: 397 Bit Score: 47.37 E-value: 8.47e-06
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
81-234 |
5.77e-05 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 45.30 E-value: 5.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 81 LGIELYVKVEGSNPTGSFKDRG---MSVGITK-ALELGVDtvgCASTGNTSASLAAYAARAGLGCVVLLPSGKVALgKLA 156
Cdd:PLN02550 122 LGVKVLLKREDLQPVFSFKLRGaynMMAKLPKeQLDKGVI---CSSAGNHAQGVALSAQRLGCDAVIAMPVTTPEI-KWQ 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 157 QAMFHGARVLSVRGNFDEALEAVTELALM-GELYLLNSVNPFRLEGQKSIGFEIVDDLgwESP-DRIILPVGNAGNISAI 234
Cdd:PLN02550 198 SVERLGATVVLVGDSYDEAQAYAKQRALEeGRTFIPPFDHPDVIAGQGTVGMEIVRQH--QGPlHAIFVPVGGGGLIAGI 275
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
67-169 |
2.40e-04 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 43.06 E-value: 2.40e-04
|
| PRK13028 |
PRK13028 |
tryptophan synthase subunit beta; Provisional |
162-377 |
7.21e-04 |
|
tryptophan synthase subunit beta; Provisional
Pssm-ID: 183851 Cd Length: 402 Bit Score: 41.39 E-value: 7.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 162 GARVLSV-RGN------FDEALEA-VTELALMgeLYLLNSV---NPFRL---EGQKSIGFE----IVDDLGwESPDRIIL 223
Cdd:PRK13028 160 GAEVVPVtRGGrtlkeaVDSAFEDyLKDPDNT--HYAIGSVvgpHPFPMmvrDFQSVIGEEareqFLEMTG-RLPDAVVA 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 224 PVGNAGNisAIwkGIseFyrAGFIDERPM-MTGIQAEGASP---------------VVEAFR-------KGrtEIEPVrd 280
Cdd:PRK13028 237 CVGGGSN--AI--GL--F--SAFLDDESVrLVGVEPAGRGLdlgehaatltlgkpgVIHGFKsyvlqdeDG--EPAPV-- 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 281 pETVATAIR---IGAPVSYLKAL-RAIYESdgyaesVTDEEILSAQKLLARREGIgvEPA--SAASIAGLIKLVDEgvVD 354
Cdd:PRK13028 305 -HSIAAGLDypgVGPEHAYLKDIgRVEYVT------ATDEEALDAFFLLSRTEGI--IPAleSSHAVAYAIKLAPE--LS 373
|
250 260
....*....|....*....|...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 355 RGERVVCVVTGHVLKDPDTAIKA 377
Cdd:PRK13028 374 KDETILVNLSGRGDKDIDYVAEM 396
|
|
| PLN02618 |
PLN02618 |
tryptophan synthase, beta chain |
290-376 |
1.21e-03 |
|
tryptophan synthase, beta chain
Pssm-ID: 215333 Cd Length: 410 Bit Score: 40.89 E-value: 1.21e-03
|
| PRK13803 |
PRK13803 |
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional |
69-379 |
1.24e-03 |
|
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
Pssm-ID: 237513 [Multi-domain] Cd Length: 610 Bit Score: 40.95 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 69 TPFVRCDTIGSELGIELYVKVEGSNPTGSFKdrgMSVGITKAL---ELGVDTVgCASTG--NTSASLAAYAARAGLGCVV 143
Cdd:PRK13803 272 TPLTEAKRLSDIYGARIYLKREDLNHTGSHK---INNALGQALlakRMGKTRI-IAETGagQHGVATATACALFGLKCTI 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 144 LLpsGKVALGKLAQAMFH----GARVLSVRGNFDEALEAVTElALM-------GELYLLNSV---NPFRL---EGQKSIG 206
Cdd:PRK13803 348 FM--GEEDIKRQALNVERmkllGANVIPVLSGSKTLKDAVNE-AIRdwvasvpDTHYLIGSAvgpHPYPEmvaYFQSVIG 424
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 207 FEIVDDLGWES---PDRIILPVGNAGNISAIwkgiseFYraGFIDERPM-MTGIQAEG-------ASPVVEAFRKG---- 271
Cdd:PRK13803 425 EEAKEQLKEQTgklPDAIIACVGGGSNAIGI------FY--HFLDDPSVkLIGVEAGGkgvntgeHAATIKKGRKGvlhg 496
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 272 -RTEIEPVRDPETVAT-AIR-------IGAPVSYLKAL-RAIYESdgyaesVTDEEILSAQKLLARREGIGVEPASAASI 341
Cdd:PRK13803 497 sMTYLMQDENGQILEPhSISagldypgIGPMHANLFETgRAIYTS------VTDEEALDAFKLLAKLEGIIPALESSHAL 570
|
330 340 350
....*....|....*....|....*....|....*...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 342 AGLIKLvdEGVVDRGERVVCVVTGHVLKDPDTAIKAST 379
Cdd:PRK13803 571 AYLKEG--RKKFKKKDIVIVNLSGRGDKDIPTLKEYFE 606
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
67-101 |
2.02e-03 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 39.84 E-value: 2.02e-03
|
| ACCD |
cd06449 |
Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme ... |
304-365 |
4.61e-03 |
|
Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia.
Pssm-ID: 107210 Cd Length: 307 Bit Score: 38.56 E-value: 4.61e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 304 YESDGYAesVTDEEILSAQKLLARREGIGVEPA-SAASIAGLIKLVDEGVVDRGERVVCVVTG 365
Cdd:cd06449 246 YAAPEYG--IPNDETIEAIKLCARLEGIITDPVyEGKSMQGMIDLVRNGEFKEGSKVLFIHLG 306
|
|
| PRK08206 |
PRK08206 |
diaminopropionate ammonia-lyase; Provisional |
69-221 |
8.91e-03 |
|
diaminopropionate ammonia-lyase; Provisional
Pssm-ID: 236186 Cd Length: 399 Bit Score: 37.94 E-value: 8.91e-03
|
| D-Ser-dehyd |
cd06447 |
D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
280-350 |
9.07e-03 |
|
D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive antagonist of beta-alanine in the biosynthetic pathway to pentothenate and coenzyme A. D-serine dehydratase is different from other pyridoxal-5'-phosphate-dependent enzymes in that it catalyzes alpha, beta-elimination reactions on amino acids.
Pssm-ID: 107208 Cd Length: 404 Bit Score: 38.10 E-value: 9.07e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
seqsig_MIRCI_5117cf6d15e0fd8ebab6f24491d8c659 280 DPETVATAIRIGAPVSYL-KALRAIYesDGYAeSVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDE 350
Cdd:cd06447 306 DNRTAADGLAVGRPSGLVgKLMEPLL--SGIY-TVEDDELYRLLAMLKDSENIEVEPSAAAGFTGPAQVLSE 374
|
|
| |
