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Conserved domains on  [gi|937408147|ref|YP_009166338|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Microtus ochrogaster]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.74e-73

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 218.13  E-value: 1.74e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   1 MTELIYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147  81 ALVSSWLTIGIMFMSLFMELGMLFVNNYYEGMELMLEFNSMGGWVVYDGDELGLMGEGGAGVAALYDCSAWLMFVSGWTL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|....
gi 937408147 161 LMGVLIIIEITRGN 174
Cdd:MTH00109 162 FIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.74e-73

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 218.13  E-value: 1.74e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   1 MTELIYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147  81 ALVSSWLTIGIMFMSLFMELGMLFVNNYYEGMELMLEFNSMGGWVVYDGDELGLMGEGGAGVAALYDCSAWLMFVSGWTL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|....
gi 937408147 161 LMGVLIIIEITRGN 174
Cdd:MTH00109 162 FIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 3.62e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 55.20  E-value: 3.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   17 LGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPEALVSSWLTIGIMFMSL 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 937408147   97 FMELGMLFVNnyyeGMELMLEFNSMGGWVVYDGDELGLmgeggagvaALYDCSAWLMFVSGWTLLMGVLIIIEI 170
Cdd:pfam00499  81 LLLALLLLVL----LSASLTPAAAAAAPDVGNIEAIGE---------LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.74e-73

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 218.13  E-value: 1.74e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   1 MTELIYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147  81 ALVSSWLTIGIMFMSLFMELGMLFVNNYYEGMELMLEFNSMGGWVVYDGDELGLMGEGGAGVAALYDCSAWLMFVSGWTL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|....
gi 937408147 161 LMGVLIIIEITRGN 174
Cdd:MTH00109 162 FIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 5.47e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 99.83  E-value: 5.47e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   1 MTELIYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147  81 ALVS-SWLTIGIMFMSLFMELGMLFVNNYYEGMELmlefnsmggwVVYDGDELGLMGEGGAGVAALYDCSAWLMFVSGWT 159
Cdd:MTH00138  81 SWGSwSVLGYVVGYLVGVVLAAGLFWGGWYEGSWV----------VVDELKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                        170
                 ....*....|....
gi 937408147 160 LLMGVLIIIEITRG 173
Cdd:MTH00138 151 LLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 6.96e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 96.84  E-value: 6.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   1 MTELIYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147  81 ALVSSWLTIGIMFMSLFMELGMLFVNNYYegmelmlefnSMGGWVVYDGDELGLMGEGGAGVAALYDCSAWLMFVSGWTL 160
Cdd:MTH00065  81 AWGSWSVLVYVLFYLLLLIVGYILFGCNF----------SLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|...
gi 937408147 161 LMGVLIIIEITRG 173
Cdd:MTH00065 151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 5.21e-18

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 76.71  E-value: 5.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   1 MTELIYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147  81 AlvssWLTIGIMFMSLFMELGMLFVNNYYEGMELMLEFnsmgGWVVYDGDELGLMGEGGAGVAALYDCSAWLMFVSGWTL 160
Cdd:MTH00115  81 A----WGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGV----GVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|...
gi 937408147 161 LMGVLIIIEITRG 173
Cdd:MTH00115 153 LLTLFVVLELVRG 165
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 5-174 1.17e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 59.53  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   5 IYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPeaLVS 84
Cdd:MTH00045   3 FYLFLILMLFGSTLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP--SVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147  85 SWLTIGIMFMSLFMELGMLFVNNYyegmelmlefnsmgGWVVYDGDELGLMGEGGAGVaaLYDCSAWLMFVSGWTLLMGV 164
Cdd:MTH00045  81 NLGEVLVLSLLLSLWVFISFDNFL--------------ELSNNNWSLVSLSDLVGSSE--LYNSGGLYLLLGGFILLVAL 144

                        170
                 ....*....|
gi 937408147 165 LIIIEITRGN 174
Cdd:MTH00045 145 VVALVISFGH 154
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 9.87e-11

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 57.31  E-value: 9.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   1 MTELIYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147  81 alvsSWLTIGIMFMSLFMELGMLFVNNYYEGMELMLEFNSMGgwvvydgdelGLMGEGGAGVAALYDCSAWLMFVSGWTL 160
Cdd:MTH00214  81 ----SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVD----------EANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|...
gi 937408147 161 LMGVLIIIEITRG 173
Cdd:MTH00214 147 FLVLFVVLELVRG 159
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 3.62e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 55.20  E-value: 3.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   17 LGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYPEALVSSWLTIGIMFMSL 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 937408147   97 FMELGMLFVNnyyeGMELMLEFNSMGGWVVYDGDELGLmgeggagvaALYDCSAWLMFVSGWTLLMGVLIIIEI 170
Cdd:pfam00499  81 LLLALLLLVL----LSASLTPAAAAAAPDVGNIEAIGE---------LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 4-116 3.58e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 41.92  E-value: 3.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   4 LIYLLSSVLALGCLgASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEEYpeaLV 83
Cdd:MTH00212   3 LSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH---LF 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 937408147  84 SSWLTIGIMFMSLFMELGMLFVNNYYEGMELML 116
Cdd:MTH00212  79 FKKYFKGFGMILISLNLYLLLMTLGSSNFSPML 111
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 4-131 1.00e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 40.64  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937408147   4 LIYLLSSVLALGCLGASLKPSPIHGGLCLIVSGCCGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAeEYPEALV 83
Cdd:MTH00152   2 SLMILLSVCFSLFLLLPLSKQPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLSP-NPLFGSN 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 937408147  84 SSWLTIGIMFMSLFMELGMLFVNNYYEGMELMLEFNSMGGWVVYDGDE 131
Cdd:MTH00152  81 FKFVFFSLTLFGFLGLFFFFLYLYSSGGLSLSSLFDGSSGSLSFGGGL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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