|
Name |
Accession |
Description |
Interval |
E-value |
| MutY |
COG1194 |
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ... |
1-345 |
2.59e-173 |
|
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];
Pssm-ID: 440807 [Multi-domain] Cd Length: 350 Bit Score: 485.03 E-value: 2.59e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 1 MNIFSETLLGWYADNARELPWRNTKDPYLIWVSEIILQQTRVAQGYDYFLRFVQRFPDVHALAEASEDEVMKYWQGLGYY 80
Cdd:COG1194 3 MASFAKRLLAWYDRHGRDLPWRQTRDPYRVWLSEIMLQQTQVATVIPYYERFLERFPTVEALAAAPEDEVLKLWEGLGYY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 81 SRARNLHEAARSM----NGVFPSTYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDSAEGKKL 156
Cdd:COG1194 83 SRARNLHKAAQQVveehGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVDGNVKRVLSRLFAIEGPIGSPAAKKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 157 FAALAQEMLPASRPAEYNQAIMDFGAIQCTPQSPLCMYCPLCDTCAALAQGRVDQLPVKQHKTKTTDRFFNYIYVRAGAY 236
Cdd:COG1194 163 LWALAEELLPPERPGDFNQALMDLGATVCTPKKPKCLLCPLQDDCAAFAEGRQEELPVKKPKKKKPERYGAALVIRDDGR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 237 TYINKRTGNDIWKNLFELPLIETERDMPEAEFVQLPQFRDLFAAEDKPQLrclrRGVKHVLSHRVIYASFYEVVLPEETR 316
Cdd:COG1194 243 VLLEKRPPKGLWGGLWEFPEFEWEEAEDPEALERWLREELGLEVEWLEPL----GTVRHVFTHFRLHLTVYLARVPAGPP 318
|
330 340 350
....*....|....*....|....*....|
gi 2527002804 317 -SFSAYRRVSREELGQYAVPRLIHAFLEKY 345
Cdd:COG1194 319 aEPDGGRWVPLEELAALPLPAPMRKLLKAL 348
|
|
| mutY |
TIGR01084 |
A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the ... |
4-260 |
1.31e-106 |
|
A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130156 Cd Length: 275 Bit Score: 313.19 E-value: 1.31e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 4 FSETLLGWYADNARE-LPWRNTKDPYLIWVSEIILQQTRVAQGYDYFLRFVQRFPDVHALAEASEDEVMKYWQGLGYYSR 82
Cdd:TIGR01084 2 FSEDLLSWYDKYGRKtLPWRQNKTPYRVWLSEVMLQQTQVATVIPYFERFLERFPTVQALANAPQDEVLKLWEGLGYYAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 83 ARNLHEAARSM----NGVFPSTYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDSAEGKKLFA 158
Cdd:TIGR01084 82 ARNLHKAAQEVveefGGEFPQDFEDLAALPGVGRYTAGAILSFALNKPYPILDGNVKRVLSRLFAVEGWPGKKKVENRLW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 159 ALAQEMLPASRPAEYNQAIMDFGAIQCTPQSPLCMYCPLCDTCAALAQGRVDQLPVKQHKTKTTDR--FFNYIYVRAGAY 236
Cdd:TIGR01084 162 TLAESLLPKADPEAFNQALMDLGAMICTRKKPKCDLCPLQDFCLAYQQGTWEEYPVKKPKAAPPERttYFLVLQNYDGEV 241
|
250 260
....*....|....*....|....
gi 2527002804 237 tYINKRTGNDIWKNLFELPLIETE 260
Cdd:TIGR01084 242 -LLEQRPEKGLWGGLYCFPQFEDE 264
|
|
| PRK10880 |
PRK10880 |
adenine DNA glycosylase; |
4-279 |
2.14e-74 |
|
adenine DNA glycosylase;
Pssm-ID: 182805 [Multi-domain] Cd Length: 350 Bit Score: 233.45 E-value: 2.14e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 4 FSETLLGWYADNARE-LPWRNTKDPYLIWVSEIILQQTRVAQGYDYFLRFVQRFPDVHALAEASEDEVMKYWQGLGYYSR 82
Cdd:PRK10880 6 FSAQVLDWYDKYGRKtLPWQIDKTPYKVWLSEVMLQQTQVATVIPYFERFMARFPTVTDLANAPLDEVLHLWTGLGYYAR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 83 ARNLHEAARSM----NGVFPSTYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDSAEGKKLFA 158
Cdd:PRK10880 86 ARNLHKAAQQVatlhGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARCYAVSGWPGKKEVENRLW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 159 ALAQEMLPASRPAEYNQAIMDFGAIQCTPQSPLCMYCPLCDTCAALAQGRVDQLPVKQHKTKTTDRFFNYIYVRAGAYTY 238
Cdd:PRK10880 166 QLSEQVTPAVGVERFNQAMMDLGAMVCTRSKPKCELCPLQNGCIAYANHSWALYPGKKPKQTLPERTGYFLLLQHGDEVW 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2527002804 239 INKRTGNDIWKNLFELPLIETE---------RDMPEAEFVQLPQFRDLFA 279
Cdd:PRK10880 246 LEQRPPSGLWGGLFCFPQFADEeelrqwlaqRGIAADNLTQLTAFRHTFS 295
|
|
| ENDO3c |
cd00056 |
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
28-181 |
5.10e-47 |
|
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
Pssm-ID: 238013 [Multi-domain] Cd Length: 158 Bit Score: 156.63 E-value: 5.10e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 28 YLIWVSEIILQQTRVAQGYDYFLRFVQRF-PDVHALAEASEDEVMKYWQGLGYYSRARNLHEAARS----MNGVF---PS 99
Cdd:cd00056 1 FEVLVSEILSQQTTDKAVNKAYERLFERYgPTPEALAAADEEELRELIRSLGYRRKAKYLKELARAivegFGGLVlddPD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 100 TYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDsaegKKLFAALAQEMLPASRPAEYNQAIMD 179
Cdd:cd00056 81 AREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPKKKT----PEELEELLEELLPKPYWGEANQALMD 156
|
..
gi 2527002804 180 FG 181
Cdd:cd00056 157 LG 158
|
|
| ENDO3c |
smart00478 |
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
36-183 |
6.94e-37 |
|
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
Pssm-ID: 214684 [Multi-domain] Cd Length: 149 Bit Score: 130.08 E-value: 6.94e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 36 ILQQTRVAQGYDYFLRFVQRFPDVHALAEASEDEVMKYWQGLG-YYSRARNLHEAARSM----NGVFPSTYEGVRALKGV 110
Cdd:smart00478 1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGfYRRKARYLIELARILveeyGGEVPDDREELLKLPGV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2527002804 111 GDYTAAAICSIAYGMPYAVVDGNVYRVLSRyWGIevpIDSAEGKKLFAALAQEMLPASRPAEYNQAIMDFGAI 183
Cdd:smart00478 81 GRKTANAVLSFALGKPFIPVDTHVLRIAKR-LGL---VDKKSTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
|
|
| HhH-GPD |
pfam00730 |
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ... |
32-166 |
1.31e-28 |
|
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.
Pssm-ID: 425841 [Multi-domain] Cd Length: 141 Bit Score: 107.76 E-value: 1.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 32 VSEIILQQTRVAQGYDYFLRFVQR-FPDVHALAEASEDEVMKYWQGLGYY-SRARNLHEAARSM----NGVFPSTY-EGV 104
Cdd:pfam00730 1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYrRKAKYLKELARILvegyGGEVPLDEeELE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2527002804 105 RALKGVGDYTAAAICSIAYGMPYA--VVDGNVYRVLSRYWGievpIDSAEGKKLFAALAQEMLP 166
Cdd:pfam00730 81 ALLKGVGRWTAEAVLIFALGRPDPlpVVDTHVRRVLKRLGL----IKEKPTPKEVERELEELWP 140
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MutY |
COG1194 |
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ... |
1-345 |
2.59e-173 |
|
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];
Pssm-ID: 440807 [Multi-domain] Cd Length: 350 Bit Score: 485.03 E-value: 2.59e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 1 MNIFSETLLGWYADNARELPWRNTKDPYLIWVSEIILQQTRVAQGYDYFLRFVQRFPDVHALAEASEDEVMKYWQGLGYY 80
Cdd:COG1194 3 MASFAKRLLAWYDRHGRDLPWRQTRDPYRVWLSEIMLQQTQVATVIPYYERFLERFPTVEALAAAPEDEVLKLWEGLGYY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 81 SRARNLHEAARSM----NGVFPSTYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDSAEGKKL 156
Cdd:COG1194 83 SRARNLHKAAQQVveehGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVDGNVKRVLSRLFAIEGPIGSPAAKKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 157 FAALAQEMLPASRPAEYNQAIMDFGAIQCTPQSPLCMYCPLCDTCAALAQGRVDQLPVKQHKTKTTDRFFNYIYVRAGAY 236
Cdd:COG1194 163 LWALAEELLPPERPGDFNQALMDLGATVCTPKKPKCLLCPLQDDCAAFAEGRQEELPVKKPKKKKPERYGAALVIRDDGR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 237 TYINKRTGNDIWKNLFELPLIETERDMPEAEFVQLPQFRDLFAAEDKPQLrclrRGVKHVLSHRVIYASFYEVVLPEETR 316
Cdd:COG1194 243 VLLEKRPPKGLWGGLWEFPEFEWEEAEDPEALERWLREELGLEVEWLEPL----GTVRHVFTHFRLHLTVYLARVPAGPP 318
|
330 340 350
....*....|....*....|....*....|
gi 2527002804 317 -SFSAYRRVSREELGQYAVPRLIHAFLEKY 345
Cdd:COG1194 319 aEPDGGRWVPLEELAALPLPAPMRKLLKAL 348
|
|
| mutY |
TIGR01084 |
A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the ... |
4-260 |
1.31e-106 |
|
A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130156 Cd Length: 275 Bit Score: 313.19 E-value: 1.31e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 4 FSETLLGWYADNARE-LPWRNTKDPYLIWVSEIILQQTRVAQGYDYFLRFVQRFPDVHALAEASEDEVMKYWQGLGYYSR 82
Cdd:TIGR01084 2 FSEDLLSWYDKYGRKtLPWRQNKTPYRVWLSEVMLQQTQVATVIPYFERFLERFPTVQALANAPQDEVLKLWEGLGYYAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 83 ARNLHEAARSM----NGVFPSTYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDSAEGKKLFA 158
Cdd:TIGR01084 82 ARNLHKAAQEVveefGGEFPQDFEDLAALPGVGRYTAGAILSFALNKPYPILDGNVKRVLSRLFAVEGWPGKKKVENRLW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 159 ALAQEMLPASRPAEYNQAIMDFGAIQCTPQSPLCMYCPLCDTCAALAQGRVDQLPVKQHKTKTTDR--FFNYIYVRAGAY 236
Cdd:TIGR01084 162 TLAESLLPKADPEAFNQALMDLGAMICTRKKPKCDLCPLQDFCLAYQQGTWEEYPVKKPKAAPPERttYFLVLQNYDGEV 241
|
250 260
....*....|....*....|....
gi 2527002804 237 tYINKRTGNDIWKNLFELPLIETE 260
Cdd:TIGR01084 242 -LLEQRPEKGLWGGLYCFPQFEDE 264
|
|
| PRK10880 |
PRK10880 |
adenine DNA glycosylase; |
4-279 |
2.14e-74 |
|
adenine DNA glycosylase;
Pssm-ID: 182805 [Multi-domain] Cd Length: 350 Bit Score: 233.45 E-value: 2.14e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 4 FSETLLGWYADNARE-LPWRNTKDPYLIWVSEIILQQTRVAQGYDYFLRFVQRFPDVHALAEASEDEVMKYWQGLGYYSR 82
Cdd:PRK10880 6 FSAQVLDWYDKYGRKtLPWQIDKTPYKVWLSEVMLQQTQVATVIPYFERFMARFPTVTDLANAPLDEVLHLWTGLGYYAR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 83 ARNLHEAARSM----NGVFPSTYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDSAEGKKLFA 158
Cdd:PRK10880 86 ARNLHKAAQQVatlhGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARCYAVSGWPGKKEVENRLW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 159 ALAQEMLPASRPAEYNQAIMDFGAIQCTPQSPLCMYCPLCDTCAALAQGRVDQLPVKQHKTKTTDRFFNYIYVRAGAYTY 238
Cdd:PRK10880 166 QLSEQVTPAVGVERFNQAMMDLGAMVCTRSKPKCELCPLQNGCIAYANHSWALYPGKKPKQTLPERTGYFLLLQHGDEVW 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2527002804 239 INKRTGNDIWKNLFELPLIETE---------RDMPEAEFVQLPQFRDLFA 279
Cdd:PRK10880 246 LEQRPPSGLWGGLFCFPQFADEeelrqwlaqRGIAADNLTQLTAFRHTFS 295
|
|
| ENDO3c |
cd00056 |
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
28-181 |
5.10e-47 |
|
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
Pssm-ID: 238013 [Multi-domain] Cd Length: 158 Bit Score: 156.63 E-value: 5.10e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 28 YLIWVSEIILQQTRVAQGYDYFLRFVQRF-PDVHALAEASEDEVMKYWQGLGYYSRARNLHEAARS----MNGVF---PS 99
Cdd:cd00056 1 FEVLVSEILSQQTTDKAVNKAYERLFERYgPTPEALAAADEEELRELIRSLGYRRKAKYLKELARAivegFGGLVlddPD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 100 TYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDsaegKKLFAALAQEMLPASRPAEYNQAIMD 179
Cdd:cd00056 81 AREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPKKKT----PEELEELLEELLPKPYWGEANQALMD 156
|
..
gi 2527002804 180 FG 181
Cdd:cd00056 157 LG 158
|
|
| ENDO3c |
smart00478 |
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
36-183 |
6.94e-37 |
|
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
Pssm-ID: 214684 [Multi-domain] Cd Length: 149 Bit Score: 130.08 E-value: 6.94e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 36 ILQQTRVAQGYDYFLRFVQRFPDVHALAEASEDEVMKYWQGLG-YYSRARNLHEAARSM----NGVFPSTYEGVRALKGV 110
Cdd:smart00478 1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGfYRRKARYLIELARILveeyGGEVPDDREELLKLPGV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2527002804 111 GDYTAAAICSIAYGMPYAVVDGNVYRVLSRyWGIevpIDSAEGKKLFAALAQEMLPASRPAEYNQAIMDFGAI 183
Cdd:smart00478 81 GRKTANAVLSFALGKPFIPVDTHVLRIAKR-LGL---VDKKSTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
|
|
| HhH-GPD |
pfam00730 |
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ... |
32-166 |
1.31e-28 |
|
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.
Pssm-ID: 425841 [Multi-domain] Cd Length: 141 Bit Score: 107.76 E-value: 1.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 32 VSEIILQQTRVAQGYDYFLRFVQR-FPDVHALAEASEDEVMKYWQGLGYY-SRARNLHEAARSM----NGVFPSTY-EGV 104
Cdd:pfam00730 1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYrRKAKYLKELARILvegyGGEVPLDEeELE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2527002804 105 RALKGVGDYTAAAICSIAYGMPYA--VVDGNVYRVLSRYWGievpIDSAEGKKLFAALAQEMLP 166
Cdd:pfam00730 81 ALLKGVGRWTAEAVLIFALGRPDPlpVVDTHVRRVLKRLGL----IKEKPTPKEVERELEELWP 140
|
|
| Nth |
COG0177 |
Endonuclease III [Replication, recombination and repair]; |
6-201 |
6.66e-28 |
|
Endonuclease III [Replication, recombination and repair];
Pssm-ID: 439947 [Multi-domain] Cd Length: 198 Bit Score: 107.87 E-value: 6.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 6 ETLLGWYADNARELPWRNtkdPYLIWVSEIILQQT---RVAQGYDyflRFVQRFPDVHALAEASEDEVMKYWQGLGYY-S 81
Cdd:COG0177 2 ERLKELYPDAKTELDYRD---PFELLVATILSAQTtdeRVNKATP---RLFARYPTPEALAAADLEELEELIRPIGLYrN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 82 RARNLHEAARSM----NGVFPSTYEGVRALKGVGDYTAAAICSIAYGMPYAVVDGNVYRVLSRyWGIeVPIDSAEgkKLF 157
Cdd:COG0177 76 KAKNIIALARILvekyGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNR-LGL-VPGKDPE--EVE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2527002804 158 AALaQEMLPASRPAEYNQAIMDFGAIQCTPQSPLCMYCPLCDTC 201
Cdd:COG0177 152 KDL-MKLIPKEYWGDLHHLLILHGRYICKARKPKCEECPLADLC 194
|
|
| PRK13910 |
PRK13910 |
DNA glycosylase MutY; Provisional |
38-201 |
1.37e-25 |
|
DNA glycosylase MutY; Provisional
Pssm-ID: 172427 [Multi-domain] Cd Length: 289 Bit Score: 103.95 E-value: 1.37e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 38 QQTRVAQGYD-YFLRFVQRFPDVHALAEASEDEVMKYWQGLGYYSRARNLHEAA----RSMNGVFPSTYEGVRALKGVGD 112
Cdd:PRK13910 3 QQTQINTVVErFYSPFLEAFPTLKDLANAPLEEVLLLWRGLGYYSRAKNLKKSAeicvKEHHSQLPNDYQSLLKLPGIGA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 113 YTAAAICSIAYGMPYAVVDGNVYRVLSRYWGIEVPIDSaegkKLFAALAQEMLPASRPAEYNQAIMDFGAIQCTPQsPLC 192
Cdd:PRK13910 83 YTANAILCFGFREKSACVDANIKRVLLRLFGLDPNIHA----KDLQIKANDFLNLNESFNHNQALIDLGALICSPK-PKC 157
|
....*....
gi 2527002804 193 MYCPLCDTC 201
Cdd:PRK13910 158 AICPLNPYC 166
|
|
| NUDIX_DNA_Glycosylase_C-MutY |
cd03431 |
C-terminal domain of DNA glycosylase; DNA glycosylase (MutY in bacteria and hMYH in humans) is ... |
224-343 |
1.30e-23 |
|
C-terminal domain of DNA glycosylase; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the NUDIX hydrolase superfamily and is important for the repair of various genotoxic lesions. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity. They are also recognized by a highly conserved 23-residue NUDIX motif (GX5EX7REUXEEXGU, where U = I, L or V). However, DNA glycosylase does not seem to contain this signature motif. DNA glycosylase consists of 2 domains: the N-terminal domain contains the catalytic properties of the enzyme and the C-terminal domain affects substrate (oxoG) binding and enzymatic turnover. The C-terminal domain is highly similar to MutT, based on secondary structure and topology, despite low sequence identity. MutT sanitizes the nucleotide precursor pool by hydrolyzing oxo-dGTP to oxo-dGMO and inorganic pyrophosphate. The similarity strongly suggests that the two proteins share a common evolutionary origin.
Pssm-ID: 467537 [Multi-domain] Cd Length: 118 Bit Score: 93.91 E-value: 1.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 224 RFFNYIYVRAGAYTYINKRTGNDIWKNLFELPLIETERDMPEAEFVQLPQFRDLFAAEDKPqlrclrRGVKHVLSHRVIY 303
Cdd:cd03431 4 RYFTVLVLRDGGRVLLEKRPEKGLLAGLWEFPLVETEEEEEEAEALLGLLAEELLLILEPL------GEVKHVFSHFRLH 77
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2527002804 304 ASFYEVVLPEET-RSFSAYRRVSREELGQYAVPRLIHAFLE 343
Cdd:cd03431 78 ITVYLVELPEAPpAAPDEGRWVDLEELDEYALPAPMRKLLE 118
|
|
| NUDIX_4 |
pfam14815 |
NUDIX domain; |
229-344 |
1.14e-15 |
|
NUDIX domain;
Pssm-ID: 464330 [Multi-domain] Cd Length: 114 Bit Score: 71.96 E-value: 1.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 229 IYVRAGAYTYINKRTGNDIWKNLFELPLIETERDMPEAEFVQLPQFRDLfaaedkPQLRCLRRGVKHVLSHRVIYASFYE 308
Cdd:pfam14815 4 VIRNGDGRVLLRKRPEKGLLGGLWEFPGGKVEPGETLEEALARLEELGI------EVEVLEPGTVKHVFTHFRLTLHVYL 77
|
90 100 110
....*....|....*....|....*....|....*..
gi 2527002804 309 VV-LPEETRSFSAYRRVSREELGQYAVPRLIHAFLEK 344
Cdd:pfam14815 78 VReVEGEEEPQQELRWVTPEELDKYALPAAVRKILEA 114
|
|
| HP0602 |
COG2231 |
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ... |
58-206 |
1.33e-10 |
|
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];
Pssm-ID: 441832 [Multi-domain] Cd Length: 220 Bit Score: 60.24 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 58 DVHALAEASEDEVMKYWQGLGYYSR-ARNLHEAARSMNGVFPSTYEGVR------------ALKGVGDYTAAAICSIAYG 124
Cdd:COG2231 61 DPEALAALDPEELAELIRPSGFYNQkAKRLKNLARWLVERYGGGLEKLKalpteelreellSLKGIGPETADSILLYAFN 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 125 MPYAVVDGNVYRVLSRYWGIEVPIDSAEGKKLFaalaQEMLPASrPAEYNQ--A-IMDFGAIQCTPQsPLCMYCPLCDTC 201
Cdd:COG2231 141 RPVFVVDAYTRRIFSRLGLIEEDASYDELQRLF----EENLPPD-VALYNEfhAlIVEHGKEYCKKK-PKCEECPLRDLC 214
|
....*
gi 2527002804 202 AALAQ 206
Cdd:COG2231 215 PYGGQ 219
|
|
| AlkA |
COG0122 |
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ... |
8-152 |
1.36e-05 |
|
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];
Pssm-ID: 439892 [Multi-domain] Cd Length: 255 Bit Score: 46.03 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 8 LLGWYADNARELPWRNTKDPYLIWVSEIILQQTRVAQGYDYFLRFVQR--------------FPDVHALAEASEDEvmky 73
Cdd:COG0122 65 VLAPLIERYPGLRLPRRPDPFEALVRAILGQQVSVAAARTIWRRLVALfgepiegpggglyaFPTPEALAAASEEE---- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 74 WQGLGY-YSRARNLHEAAR-------SMNGVFPSTYEGVR----ALKGVGDYTAAAICSIAYGMP--YAVVDGNVYRVLS 139
Cdd:COG0122 141 LRACGLsRRKARYLRALARavadgelDLEALAGLDDEEAIarltALPGIGPWTAEMVLLFALGRPdaFPAGDLGLRRALG 220
|
170
....*....|...
gi 2527002804 140 RYWGIEVPIDSAE 152
Cdd:COG0122 221 RLYGLGERPTPKE 233
|
|
| ogg |
TIGR00588 |
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ... |
56-178 |
3.45e-04 |
|
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 211589 [Multi-domain] Cd Length: 310 Bit Score: 41.82 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2527002804 56 FPDVHALA-EASEDEVMKYwqGLGYysRARNLHEAARSM----------NGVFPSTYEGVR----ALKGVGDYTAAAICS 120
Cdd:TIGR00588 163 FPSLHALTgPEAEAHLRKL--GLGY--RARYIRETARALleeqggrawlQQIRGASYEDARealcELPGVGPKVADCICL 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2527002804 121 IAYGMPYAV-VDGNVYRVLSRYWGIE---------VPIDSAEGKKLFAALAQEMlpasrpAEYNQAIM 178
Cdd:TIGR00588 239 MGLDKPQAVpVDVHVWRIANRDYPWHpktsrakgpSPFARKELGNFFRSLWGPY------AGWAQAVL 300
|
|
| HHH |
pfam00633 |
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ... |
92-121 |
2.67e-03 |
|
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.
Pssm-ID: 425789 [Multi-domain] Cd Length: 30 Bit Score: 34.70 E-value: 2.67e-03
10 20 30
....*....|....*....|....*....|
gi 2527002804 92 SMNGVFPSTYEGVRALKGVGDYTAAAICSI 121
Cdd:pfam00633 1 SLEGLIPASVEELLALPGVGPKTAEAILSY 30
|
|
| |
