|
Name |
Accession |
Description |
Interval |
E-value |
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
1-470 |
0e+00 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 757.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 1 MQDPQTLLADIFGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAG 80
Cdd:COG0514 2 RDDALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 81 VQAGALTSGNTEEETDMVFDALHAGTLKLLYIAPERLASTGTRDMLTRAGCTMIAVDEAHCVSQWGHDFRPDYLRIGELR 160
Cdd:COG0514 82 IRAAFLNSSLSAEERREVLRALRAGELKLLYVAPERLLNPRFLELLRRLKISLFAIDEAHCISQWGHDFRPDYRRLGELR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 161 RAL-NVPLAAFTATADAETREEIVTRLFDGvQPETFMQGFDRPNLNLAFEVK--DGPRRQILDFAAAHRDQAGIVYCGTR 237
Cdd:COG0514 162 ERLpNVPVLALTATATPRVRADIAEQLGLE-DPRVFVGSFDRPNLRLEVVPKppDDKLAQLLDFLKEHPGGSGIVYCLSR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 238 AKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGR 317
Cdd:COG0514 241 KKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEAYYQEIGR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 318 AGRDGTPADTLTLYGPDDIRFRRQQIDEGLAPDDRKAADHARLNALLGLAEALECRRKPLLEYFGDTDIT-CGNCDLCDK 396
Cdd:COG0514 321 AGRDGLPAEALLLYGPEDVAIQRFFIEQSPPDEERKRVERAKLDAMLAYAETTGCRRQFLLRYFGEELAEpCGNCDNCLG 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 750537477 397 APDTFDGTVAVRKALSAILRTGEYFGAGHLIDILLGNSTDKVQARGHDQLPTFGIGGEYDKRGWQAVFRQMMGR 470
Cdd:COG0514 401 PPETFDGTEAAQKALSCVYRTGQRFGAGHVIDVLRGSKNEKIRQFGHDKLSTYGIGKDLSDKEWRSVIRQLLAQ 474
|
|
| recQ |
TIGR01389 |
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ... |
5-590 |
0e+00 |
|
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273594 [Multi-domain] Cd Length: 591 Bit Score: 702.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 5 QTLLADIFGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQAG 84
Cdd:TIGR01389 2 QQVLKRTFGYDDFRPGQEEIISHVLDGRDVLVVMPTGGGKSLCYQVPALLLKGLTVVISPLISLMKDQVDQLRAAGVAAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 85 ALTSGNTEEETDMVFDALHAGTLKLLYIAPERLASTGTRDMLTRAGCTMIAVDEAHCVSQWGHDFRPDYLRIGELRRAL- 163
Cdd:TIGR01389 82 YLNSTLSAKEQQDIEKALVNGELKLLYVAPERLEQDYFLNMLQRIPIALVAVDEAHCVSQWGHDFRPEYQRLGSLAERFp 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 164 NVPLAAFTATADAETREEIVTRLfDGVQPETFMQGFDRPNLNLAFEVKDGPRRQILDFAAAHRDQAGIVYCGTRAKTETL 243
Cdd:TIGR01389 162 QVPRIALTATADAETRQDIRELL-RLADANEFITSFDRPNLRFSVVKKNNKQKFLLDYLKKHRGQSGIIYASSRKKVEEL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 244 AQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDGT 323
Cdd:TIGR01389 241 AERLESQGISALAYHAGLSNKVRAENQEDFLYDDVKVMVATNAFGMGIDKPNVRFVIHYDMPGNLESYYQEAGRAGRDGL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 324 PADTLTLYGPDDIRFRRQQIDEGLAPDDRKAADHARLNALLGLAEALECRRKPLLEYFGDTDIT-CGNCDLCDKAPDTFD 402
Cdd:TIGR01389 321 PAEAILLYSPADIALLKRRIEQSEADDDYKQIEREKLRAMIAYCETQTCRRAYILRYFGENEVEpCGNCDNCLDPPKSYD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 403 GTVAVRKALSAILRTGEYFGAGHLIDILLGNSTDKVQARGHDQLPTFGIGGEYDKRGWQAVFRQMMGRDLIRPDPSRHGA 482
Cdd:TIGR01389 401 ATVEAQKALSCVYRMGQRFGVGYIIEVLRGSKNDKILQKGHDQLSTYGIGKDYTQKEWRSLIDQLIAEGLLTENDEIYIG 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 483 FRMTEAARPILRDEATITLRRDTIKKGANRPAVKTLVSDEDAPLLSALKAKRRAFAEAARVPAYVIFNDKTLIEMAETRP 562
Cdd:TIGR01389 481 LQLTEAARKVLKNEVEVLLRPFKVVAKEKTRVQKNLSVGVDNALFEALRELRKEQADEQNVPPYVIFSDSTLREMAEKRP 560
|
570 580
....*....|....*....|....*...
gi 750537477 563 ADLDAFARISGVGAKKLESFGAAFLEVI 590
Cdd:TIGR01389 561 ATLNALLKIKGVGQNKLDRYGEAFLEVI 588
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
4-590 |
0e+00 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 600.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 4 PQTLLADIFGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQA 83
Cdd:PRK11057 13 AKQVLQETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLDGLTLVVSPLISLMKDQVDQLLANGVAA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 84 GALTSGNTEEETDMVFDALHAGTLKLLYIAPERLASTGTRDMLTRAGCTMIAVDEAHCVSQWGHDFRPDYLRIGELRRAL 163
Cdd:PRK11057 93 ACLNSTQTREQQLEVMAGCRTGQIKLLYIAPERLMMDNFLEHLAHWNPALLAVDEAHCISQWGHDFRPEYAALGQLRQRF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 164 -NVPLAAFTATADAETREEIVtRLFDGVQPETFMQGFDRPNLNLAFEVKDGPRRQILDFAAAHRDQAGIVYCGTRAKTET 242
Cdd:PRK11057 173 pTLPFMALTATADDTTRQDIV-RLLGLNDPLIQISSFDRPNIRYTLVEKFKPLDQLMRYVQEQRGKSGIIYCNSRAKVED 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 243 LAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDG 322
Cdd:PRK11057 252 TAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDG 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 323 TPADTLTLYGPDDIRFRRQQIDEGlAPDDRKAADHARLNALLGLAEALECRRKPLLEYFGDT-DITCGNCDLCDKAPDTF 401
Cdd:PRK11057 332 LPAEAMLFYDPADMAWLRRCLEEK-PAGQQQDIERHKLNAMGAFAEAQTCRRLVLLNYFGEGrQEPCGNCDICLDPPKQY 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 402 DGTVAVRKALSAILRTGEYFGAGHLIDILLGNSTDKVQARGHDQLPTFGIGGEYDKRGWQAVFRQMMGRDLIRPDPSRHG 481
Cdd:PRK11057 411 DGLEDAQKALSCIYRVNQRFGMGYVVEVLRGANNQRIRDYGHDKLKVYGIGRDKSHEHWVSVIRQLIHLGLVTQNIAQHS 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 482 AFRMTEAARPILRDEATITL---RRDTIKKGANRpavKTLVSDEDAPLLSALKAKRRAFAEAARVPAYVIFNDKTLIEMA 558
Cdd:PRK11057 491 ALQLTEAARPVLRGEVSLQLavpRIVALKPRAMQ---KSFGGNYDRKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMA 567
|
570 580 590
....*....|....*....|....*....|..
gi 750537477 559 ETRPADLDAFARISGVGAKKLESFGAAFLEVI 590
Cdd:PRK11057 568 EQMPITASEMLSVNGVGQRKLERFGKPFMALI 599
|
|
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
6-452 |
1.86e-157 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 462.32 E-value: 1.86e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 6 TLLADIFGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQAGA 85
Cdd:TIGR00614 1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 86 LTSGNTEEETDMVFDALHAGTLKLLYIAPERLASTGT--RDMLTRAGCTMIAVDEAHCVSQWGHDFRPDYLRIGELRRAL 163
Cdd:TIGR00614 81 LNSAQTKEQQLNVLTDLKDGKIKLLYVTPEKISASNRllQTLEERKGITLIAVDEAHCISQWGHDFRPDYKALGSLKQKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 164 -NVPLAAFTATADAETREEIVTRLfDGVQPETFMQGFDRPNLNLAFEVKDG-PRRQILDFA-AAHRDQAGIVYCGTRAKT 240
Cdd:TIGR00614 161 pNVPVMALTATASPSVREDILRQL-NLLNPQIFCTSFDRPNLYYEVRRKTPkILEDLLRFIrKEFEGKSGIIYCPSRKKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 241 ETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGR 320
Cdd:TIGR00614 240 EQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQESGRAGR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 321 DGTPADTLTLYGPDDIRFRRQQIDEglaPDDRKAADHAR--LNALLGLAEALECRRKPLLEYFGD-----------TDIT 387
Cdd:TIGR00614 320 DGLPSECHLFYAPADMNRLRRLLME---EPDGNFRTYKLklYEMMEYCLNSSTCRRLILLSYFGEkgfnksfcimgTEKC 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 750537477 388 CGNCDLC------DKAPDTFDGTVAVRKALSAILRTGEYFGAGHLIDILLGNSTDKVQARGHDQLPTFGIG 452
Cdd:TIGR00614 397 CDNCCKRldyktkDVTDKVYDFGPQAQKALSAVGRLNQKFGMGYPVDFLRGSNSQKIRDGGFRKHSLYGRG 467
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
11-590 |
3.18e-102 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 338.02 E-value: 3.18e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 11 IFGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQAGALTSGN 90
Cdd:PLN03137 455 VFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMNLLQANIPAASLSAGM 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 91 TEEETDMVFDALHAGT--LKLLYIAPERLA----------STGTRDMLTRagctmIAVDEAHCVSQWGHDFRPDYLRIGE 158
Cdd:PLN03137 535 EWAEQLEILQELSSEYskYKLLYVTPEKVAksdsllrhleNLNSRGLLAR-----FVIDEAHCVSQWGHDFRPDYQGLGI 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 159 LRRAL-NVPLAAFTATADAETREEIVTRLfdG-VQPETFMQGFDRPNLNLAFEVKDgprRQILD-----FAAAHRDQAGI 231
Cdd:PLN03137 610 LKQKFpNIPVLALTATATASVKEDVVQAL--GlVNCVVFRQSFNRPNLWYSVVPKT---KKCLEdidkfIKENHFDECGI 684
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 232 VYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEGY 311
Cdd:PLN03137 685 IYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGY 764
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 312 YQEIGRAGRDGTPADTLTLYGPDD-IRFRRQ----QIDEG-LAPDDRKAADHARL-----NALLGLAEALE----CRRKP 376
Cdd:PLN03137 765 HQECGRAGRDGQRSSCVLYYSYSDyIRVKHMisqgGVEQSpMAMGYNRMASSGRIletntENLLRMVSYCEnevdCRRFL 844
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 377 LLEYFGDT-DIT-CGN-CDLCDKAPDTF--DGTVAVRKALSAILRTGEYFGAGHLIDILLGNSTDKVQARGHDQLPTFGI 451
Cdd:PLN03137 845 QLVHFGEKfDSTnCKKtCDNCSSSKSLIdkDVTEIARQLVELVKLTGERFSSAHILEVYRGSLNQYVKKHRHETLSLHGA 924
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 452 GGEYDKRGWQAVFRQMMGRDLIRPDPSR---HGA----FRMTEA-ARPILRDEATITLR-RDTIK-----KGANRPAVKT 517
Cdd:PLN03137 925 GKHLSKGEASRILHYLVTEDILAEDVKKsdlYGSvsslLKVNESkAYKLFSGGQTIIMRfPSSVKaskpsKFEATPAKGP 1004
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 518 LVSDEDAP------------------LLSALKAKRRAFAEAAR--VPAYVIFNDKTLIEMAETRPADLDAFARISGVGAK 577
Cdd:PLN03137 1005 LTSGKQSTlpmatpaqppvdlnlsaiLYTALRKLRTALVKEAGdgVMAYHIFGNATLQQISKRIPRTKEELLEINGLGKA 1084
|
650
....*....|...
gi 750537477 578 KLESFGAAFLEVI 590
Cdd:PLN03137 1085 KVSKYGDRLLETI 1097
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
5-200 |
1.70e-95 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 292.90 E-value: 1.70e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 5 QTLLADIFGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQAG 84
Cdd:cd17920 1 EQILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLLDGVTLVVSPLISLMQDQVDRLQQLGIRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 85 ALTSGNTEEETDMVFDALHAGTLKLLYIAPERLASTGTRDMLTRA----GCTMIAVDEAHCVSQWGHDFRPDYLRIGELR 160
Cdd:cd17920 81 ALNSTLSPEEKREVLLRIKNGQYKLLYVTPERLLSPDFLELLQRLperkRLALIVVDEAHCVSQWGHDFRPDYLRLGRLR 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 750537477 161 RAL-NVPLAAFTATADAETREEIVTRLFDGvQPETFMQGFD 200
Cdd:cd17920 161 RALpGVPILALTATATPEVREDILKRLGLR-NPVIFRASFD 200
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
7-198 |
5.37e-69 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 223.67 E-value: 5.37e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 7 LLADIFGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPAL----ARDGLTVVISPLIALMRDQVRAMRAAgVQ 82
Cdd:cd18018 3 LLRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALllrrRGPGLTLVVSPLIALMKDQVDALPRA-IK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 83 AGALTSGNTEEETDMVFDALHAGTLKLLYIAPERLASTGTRDML-TRAGCTMIAVDEAHCVSQWGHDFRPDYLRIGELRR 161
Cdd:cd18018 82 AAALNSSLTREERRRILEKLRAGEVKILYVSPERLVNESFRELLrQTPPISLLVVDEAHCISEWSHNFRPDYLRLCRVLR 161
|
170 180 190
....*....|....*....|....*....|....*....
gi 750537477 162 ALNV--PLAAFTATADAETREEIVTRLfdGVQPETFMQG 198
Cdd:cd18018 162 ELLGapPVLALTATATKRVVEDIASHL--GIPESGVVRG 198
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
5-174 |
5.94e-63 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 207.99 E-value: 5.94e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 5 QTLLADIFGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQAG 84
Cdd:cd18015 7 KDTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKKLGISAT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 85 ALTSGNTEEETDMVFDALHAGT--LKLLYIAPERLASTGTrdMLTR------AGC-TMIAVDEAHCVSQWGHDFRPDYLR 155
Cdd:cd18015 87 MLNASSSKEHVKWVHAALTDKNseLKLLYVTPEKIAKSKR--FMSKlekaynAGRlARIAIDEVHCCSQWGHDFRPDYKK 164
|
170 180
....*....|....*....|
gi 750537477 156 IGELRRAL-NVPLAAFTATA 174
Cdd:cd18015 165 LGILKRQFpNVPILGLTATA 184
|
|
| DpdF |
NF041063 |
protein DpdF; |
3-337 |
9.71e-61 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 217.86 E-value: 9.71e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 3 DPqtLLADIFGFDAFR-PGQRDIVDAVC---AGKNTLAIMPTGGGKSLCFQLPAL---ARDGLTVVISPLIALMRDQVRA 75
Cdd:NF041063 128 DP--FLAEALGFTHYRsPGQREAVRAALlapPGSTLIVNLPTGSGKSLVAQAPALlasRQGGLTLVVVPTVALAIDQERR 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 76 MRA----AGVQAG---ALTSGNTEEETDMVFDALHAGTLKLLYIAPE-----------RLASTGtrdMLTragctMIAVD 137
Cdd:NF041063 206 AREllrrAGPDLGgplAWHGGLSAEERAAIRQRIRDGTQRILFTSPEsltgslrpalfDAAEAG---LLR-----YLVVD 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 138 EAHCVSQWGHDFRPDYLRIGELRRAL---NVPLAAF-----TATADAETREEIvTRLFDGVQPETFMQG-FDRPNLNLAF 208
Cdd:NF041063 278 EAHLVDQWGDGFRPEFQLLAGLRRSLlrlAPSGRPFrtlllSATLTESTLDTL-ETLFGPPGPFIVVSAvQLRPEPAYWV 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 209 EVKDGP---RRQILDfAAAHRDQAGIVYCGTRAKTETLAQALREAGHSACH-YHGGMDKDDRREVERRFSqEDGL-VVVA 283
Cdd:NF041063 357 AKCDSEeerRERVLE-ALRHLPRPLILYVTKVEDAEAWLQRLRAAGFRRVAlFHGDTPDAERERLIEQWR-ENELdIVVA 434
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 750537477 284 TIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDGTPADTLTLYGPDDIR 337
Cdd:NF041063 435 TSAFGLGMDKSDVRTVIHACVPETLDRFYQEVGRGGRDGKASLSLLIYTPDDLD 488
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
201-331 |
1.44e-55 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 185.49 E-value: 1.44e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 201 RPNLNLAFEVKDGPRRQILD---FAAAHRDQAGIVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQED 277
Cdd:cd18794 1 RPNLFYSVRPKDKKDEKLDLlkrIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 750537477 278 GLVVVATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDGTPADTLTLY 331
Cdd:cd18794 81 IQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
8-200 |
6.48e-52 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 178.04 E-value: 6.48e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 8 LADIFGFDAFRPGQRDIVDAVC-AGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQAGAL 86
Cdd:cd18017 4 LNEYFGHSSFRPVQWKVIRSVLeERRDNLVVMATGYGKSLCYQYPSVLLNSLTLVISPLISLMEDQVLQLVMSNIPACFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 87 TSGNTEEetdmVFDALHAGTLKLLYIAPERLasTGTRDMLT--RAGCTMIAVDEAHCVSQWGHDFRPDYLRIGELRRAL- 163
Cdd:cd18017 84 GSAQSQN----VLDDIKMGKIRVIYVTPEFV--SKGLELLQqlRNGITLIAIDEAHCVSQWGHDFRSSYRHLGSIRNRLp 157
|
170 180 190
....*....|....*....|....*....|....*..
gi 750537477 164 NVPLAAFTATADAETREEIVTRLfDGVQPETFMQGFD 200
Cdd:cd18017 158 NVPIVALTATATPSVRDDIIKNL-NLRNPQITCTSFD 193
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
5-186 |
4.38e-50 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 173.43 E-value: 4.38e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 5 QTLLADIFGFDAFR-PGQRDIVDAVCAGK-NTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQ 82
Cdd:cd18014 1 RSTLKKVFGHSDFKsPLQEKATMAVVKGNkDVFVCMPTGAGKSLCYQLPALLAKGITIVISPLIALIQDQVDHLKTLKIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 83 AGALTSGNTEEETDMVFDALHAGT--LKLLYIAPERLASTGTRDMLT----RAGCTMIAVDEAHCVSQWGHDFRPDYLRI 156
Cdd:cd18014 81 VDSLNSKLSAQERKRIIADLESEKpqTKFLYITPEMAATSSFQPLLSslvsRNLLSYLVVDEAHCVSQWGHDFRPDYLRL 160
|
170 180 190
....*....|....*....|....*....|.
gi 750537477 157 GELR-RALNVPLAAFTATADAETREEIVTRL 186
Cdd:cd18014 161 GALRsRYGHVPWVALTATATPQVQEDIFAQL 191
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
12-200 |
4.99e-50 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 173.47 E-value: 4.99e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 12 FGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQAGALTSGNT 91
Cdd:cd18016 13 FGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDKT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 92 EEETDMVFDALHAG--TLKLLYIAPERLASTG----------TRDMLTRagctmIAVDEAHCVSQWGHDFRPDYLRIGEL 159
Cdd:cd18016 93 DAEATKIYLQLSKKdpIIKLLYVTPEKISASNrlistlenlyERKLLAR-----FVIDEAHCVSQWGHDFRPDYKRLNML 167
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 750537477 160 RRAL-NVPLAAFTATADAETREEIVTRLfDGVQPETFMQGFD 200
Cdd:cd18016 168 RQKFpSVPMMALTATATPRVQKDILNQL-KMLRPQVFTMSFN 208
|
|
| RQC |
pfam09382 |
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ... |
398-504 |
1.30e-36 |
|
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 462780 [Multi-domain] Cd Length: 108 Bit Score: 132.66 E-value: 1.30e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 398 PDTFDGTVAVRKALSAILRTGEYFGAGHLIDILLGNSTDKVQARGHDQLPTFGIGGEYDKRGWQAVFRQMMGRDLIRPDP 477
Cdd:pfam09382 2 PETVDVTEEAQKILSCVYRTGQRFGAGHLIDVLRGSKNKKIRQLGHDKLSTFGIGKDLSKKEWRRIIRQLIAEGYLEVDI 81
|
90 100
....*....|....*....|....*..
gi 750537477 478 SRHGAFRMTEAARPILRDEATITLRRD 504
Cdd:pfam09382 82 EFYSVLKLTPKAREVLKGEEKVMLRVP 108
|
|
| RQC |
smart00956 |
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ... |
402-493 |
3.70e-36 |
|
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 214936 [Multi-domain] Cd Length: 92 Bit Score: 130.67 E-value: 3.70e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 402 DGTVAVRKALSAILRTGEYFGAGHLIDILLGNSTDKVQARGHDQLPTFGIGGEYDKRGWQAVFRQMMGRDLIRPDPSRHG 481
Cdd:smart00956 1 DVTEEAQKLLSCVYRTGQRFGAGHVIDVLRGSKNKKIRQKGHDRLSTFGIGKDLSKKEWRRLIRQLIAEGYLREDGGRYP 80
|
90
....*....|..
gi 750537477 482 AFRMTEAARPIL 493
Cdd:smart00956 81 YLKLTEKARPVL 92
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
18-180 |
2.16e-25 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 103.09 E-value: 2.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 18 RPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALAR------DGLTVVISPLIALMRDQVRAMRA----AGVQAGALT 87
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAldkldnGPQALVLAPTRELAEQIYEELKKlgkgLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 88 SGNTEEEtdmVFDALHagTLKLLYIAPERLAstgtrDMLTRAGCT----MIAVDEAHCVSQWGhdFRPDYLRIGELRRAl 163
Cdd:pfam00270 81 GGDSRKE---QLEKLK--GPDILVGTPGRLL-----DLLQERKLLknlkLLVLDEAHRLLDMG--FGPDLEEILRRLPK- 147
|
170
....*....|....*..
gi 750537477 164 NVPLAAFTATADAETRE 180
Cdd:pfam00270 148 KRQILLLSATLPRNLED 164
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
241-322 |
1.74e-23 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 94.59 E-value: 1.74e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 241 ETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGR 320
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 750537477 321 DG 322
Cdd:smart00490 81 AG 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
12-180 |
1.60e-22 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 96.02 E-value: 1.60e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 12 FGFDAFRPGQRDIVDAVCAG-KNTLAIMPTGGGKSLCFQLPALAR-----DGLTVVISPLIALMRDQVRAMRAAG----V 81
Cdd:smart00487 4 FGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAlkrgkGGRVLVLVPTRELAEQWAEELKKLGpslgL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 82 QAGALTSGNTEEEtdmVFDALHAGTLKLLYIAPERLASTGTRDMLTRAGCTMIAVDEAHCVSQWGhdFRPDYLRIGELRR 161
Cdd:smart00487 84 KVVGLYGGDSKRE---QLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGG--FGDQLEKLLKLLP 158
|
170
....*....|....*....
gi 750537477 162 AlNVPLAAFTATADAETRE 180
Cdd:smart00487 159 K-NVQLLLLSATPPEEIEN 176
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
21-325 |
1.04e-20 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 96.83 E-value: 1.04e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 21 QRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALAR-----DGLTVVISPLIALMRDQVRAMRA------AGVQAGALTsG 89
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEAlledpGATALYLYPTKALARDQLRRLRElaealgLGVRVATYD-G 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 90 NTEEET--------DMVF---DALHAGTLKllyiaperlASTGTRDMLtrAGCTMIAVDEAHC---V--SQWGHDFRpdy 153
Cdd:COG1205 140 DTPPEErrwirehpDIVLtnpDMLHYGLLP---------HHTRWARFF--RNLRYVVIDEAHTyrgVfgSHVANVLR--- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 154 lRigeLRRalnvpLAAF----------TAT-ADAEtreEIVTRLFDgvqpETFMQ----GFDRPNLNLAF----EVKDGP 214
Cdd:COG1205 206 -R---LRR-----ICRHygsdpqfilaSATiGNPA---EHAERLTG----RPVTVvdedGSPRGERTFVLwnppLVDDGI 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 215 RRQILDFAA------AHRDQAGIVYCGTRAKTETLAQALREA------GHSACHYHGGMDKDDRREVERRFSQEDGLVVV 282
Cdd:COG1205 270 RRSALAEAArlladlVREGLRTLVFTRSRRGAELLARYARRAlrepdlADRVAAYRAGYLPEERREIERGLRSGELLGVV 349
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 750537477 283 ATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDGTPA 325
Cdd:COG1205 350 STNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDS 392
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
218-322 |
9.83e-20 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 84.95 E-value: 9.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 218 ILDFAAAHRDQAGIVYCGTRAKTEtLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIR 297
Cdd:pfam00271 6 LLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVD 84
|
90 100
....*....|....*....|....*
gi 750537477 298 WVAHADLPKSIEGYYQEIGRAGRDG 322
Cdd:pfam00271 85 LVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HRDC |
pfam00570 |
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ... |
526-590 |
3.02e-17 |
|
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.
Pssm-ID: 425755 [Multi-domain] Cd Length: 68 Bit Score: 76.42 E-value: 3.02e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 750537477 526 LLSALKAKRRAFAEAARVPAYVIFNDKTLIEMAETRPADLDAFARISGVGAKKLESFGAAFLEVI 590
Cdd:pfam00570 4 LLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
218-320 |
2.61e-16 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 75.62 E-value: 2.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 218 ILDFAAAHRDQAGIVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIR 297
Cdd:cd18787 18 LLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRVLVATDVAARGLDIPGVD 97
|
90 100
....*....|....*....|...
gi 750537477 298 WVAHADLPKSIEGYYQEIGRAGR 320
Cdd:cd18787 98 HVINYDLPRDAEDYVHRIGRTGR 120
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
18-355 |
4.43e-16 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 81.99 E-value: 4.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 18 RPGQRDIVDAVCA-----GKNTLAIMPTGGGKSLCFQLPA--LARDGLTVVISPLIALMRDQVRAMRAagVQAGALTSGN 90
Cdd:COG1061 82 RPYQQEALEALLAalergGGRGLVVAPTGTGKTVLALALAaeLLRGKRVLVLVPRRELLEQWAEELRR--FLGDPLAGGG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 91 TEEETDMVFDALHAGtlkllyiaperLASTGTRDMLTRAgCTMIAVDEAHcvsqwgHDFRPDYLRIgeLRRALNVPLAAF 170
Cdd:COG1061 160 KKDSDAPITVATYQS-----------LARRAHLDELGDR-FGLVIIDEAH------HAGAPSYRRI--LEAFPAAYRLGL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 171 TATADAETREEIVTRLFDGV----------------QPETFMQGFDRPNLNLAFEVKDGPRRQILDFAAA---------- 224
Cdd:COG1061 220 TATPFRSDGREILLFLFDGIvyeyslkeaiedgylaPPEYYGIRVDLTDERAEYDALSERLREALAADAErkdkilrell 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 225 ---HRDQAGIVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAH 301
Cdd:COG1061 300 rehPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAIL 379
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 750537477 302 ADLPKSIEGYYQEIGRAGRDGTPADTLTLYgpdDIRFRRQQIDEGLAPDDRKAA 355
Cdd:COG1061 380 LRPTGSPREFIQRLGRGLRPAPGKEDALVY---DFVGNDVPVLEELAKDLRDLA 430
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
4-324 |
2.37e-15 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 79.45 E-value: 2.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 4 PQTLLADI--FGFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALAR-------------DGLTVVISP---L 65
Cdd:PLN00206 129 PPKLLLNLetAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRcctirsghpseqrNPLAMVLTPtreL 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 66 IALMRDQVRaMRAAGVQ-AGALTSGNteeetDMVFDALH--AGTLKLLYIAPERLASTGTRDMLTRAGCTMIAVDEAHCV 142
Cdd:PLN00206 209 CVQVEDQAK-VLGKGLPfKTALVVGG-----DAMPQQLYriQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCM 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 143 SQWGhdFRPDYLRIgelRRALNVP-LAAFTATADAETrEEIVTRLFDGV------QPetfmqgfDRPNL---NLAFEVKD 212
Cdd:PLN00206 283 LERG--FRDQVMQI---FQALSQPqVLLFSATVSPEV-EKFASSLAKDIilisigNP-------NRPNKavkQLAIWVET 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 213 GPRRQ-ILDF--AAAHRDQAGIVYCGTRAKTETLAQALREA-GHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFG 288
Cdd:PLN00206 350 KQKKQkLFDIlkSKQHFKPPAVVFVSSRLGADLLANAITVVtGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLG 429
|
330 340 350
....*....|....*....|....*....|....*.
gi 750537477 289 MGVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDGTP 324
Cdd:PLN00206 430 RGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEK 465
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
31-173 |
8.22e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 72.05 E-value: 8.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 31 GKNTLAIMPTGGGKSLCFQLPALARD----GLTVVISPLIALMRDQVRAMRAA---GVQAGALTSGNTEEEtDMVFDALH 103
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLlkkgKKVLVLVPTKALALQTAERLRELfgpGIRVAVLVGGSSAEE-REKNKLGD 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 750537477 104 AgtlKLLYIAPERLASTGTR-DMLTRAGCTMIAVDEAHCVSQWGHDFRPDYLRIGELRRaLNVPLAAFTAT 173
Cdd:cd00046 80 A---DIIIATPDMLLNLLLReDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGL-KNAQVILLSAT 146
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
207-359 |
2.78e-14 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 75.57 E-value: 2.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 207 AFEVKDGPRRQIL-DFAAAHRDQAGIVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVAT- 284
Cdd:COG0513 220 YYLVDKRDKLELLrRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATd 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 285 IAfGMGVDKPDIRWVAHADLPKSIEGYYQEIG---RAGRDGTpadTLTLYGPDDI-------RFRRQQIDE----GLAPD 350
Cdd:COG0513 300 VA-ARGIDIDDVSHVINYDLPEDPEDYVHRIGrtgRAGAEGT---AISLVTPDERrllraieKLIGQKIEEeelpGFEPV 375
|
....*....
gi 750537477 351 DRKAADHAR 359
Cdd:COG0513 376 EEKRLERLK 384
|
|
| RecQ_Zn_bind |
pfam16124 |
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ. |
333-394 |
5.77e-14 |
|
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.
Pssm-ID: 465031 [Multi-domain] Cd Length: 66 Bit Score: 66.93 E-value: 5.77e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 750537477 333 PDDIRFRRQQIDEGLAPDDRKAADHARLNALLGLAEAL-ECRRKPLLEYFGDTDIT--CGNCDLC 394
Cdd:pfam16124 1 YQDVVRLRFLIEQSEADEERKEVELQKLQAMVAYCENTtDCRRKQLLRYFGEEFDSepCGNCDNC 65
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
231-345 |
7.04e-14 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 74.09 E-value: 7.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 231 IVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEG 310
Cdd:PTZ00424 271 IIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPEN 350
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 750537477 311 YYQEIGRAGRDGTPADTLTLYGPDDI-------RFRRQQIDE 345
Cdd:PTZ00424 351 YIHRIGRSGRFGRKGVAINFVTPDDIeqlkeieRHYNTQIEE 392
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
8-320 |
3.43e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 72.62 E-value: 3.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 8 LADIFGFDAFRPGQRDIVDA-VCAGKNTLAIMPTGGGKSLCFQLP---ALARDGLTVVISPLIAL----MRDQVRAMRAA 79
Cdd:COG1204 14 FLKERGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTLIAELAilkALLNGGKALYIVPLRALasekYREFKRDFEEL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 80 GVQAGALTsGNTEEETDMVFDAlhagtlKLLYIAPERLASTgTR---DMLTRAGCtmIAVDEAHcvsqwghdfrpdylRI 156
Cdd:COG1204 94 GIKVGVST-GDYDSDDEWLGRY------DILVATPEKLDSL-LRngpSWLRDVDL--VVVDEAH--------------LI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 157 GELRRALNVplaaftatadaetrEEIVTRL---FDGVQ----------PETFMQGFD--------RPN-LNLAF------ 208
Cdd:COG1204 150 DDESRGPTL--------------EVLLARLrrlNPEAQivalsatignAEEIAEWLDaelvksdwRPVpLNEGVlydgvl 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 209 EVKDGPRR---QILDFAAAHRDQAG--IVYCGTRAKTETLAQALRE---------------------------------- 249
Cdd:COG1204 216 RFDDGSRRskdPTLALALDLLEEGGqvLVFVSSRRDAESLAKKLADelkrrltpeereeleelaeellevseethtnekl 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 250 --------AGHsachyHGGMDKDDRREVERRFsqEDGL--VVVAT--IAfgMGVDKP-------DIRWVAHADLPkSIEg 310
Cdd:COG1204 296 adclekgvAFH-----HAGLPSELRRLVEDAF--REGLikVLVATptLA--AGVNLParrviirDTKRGGMVPIP-VLE- 364
|
410
....*....|
gi 750537477 311 YYQEIGRAGR 320
Cdd:COG1204 365 FKQMAGRAGR 374
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
217-325 |
3.11e-12 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 64.59 E-value: 3.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 217 QILDFAAAHRDQagIVYCGTRAKTETLAQALREA-------GHSACHyHGGMDKDDRREVERRFSQEDGLVVVATIAFGM 289
Cdd:cd18796 30 EVIFLLERHKST--LVFTNTRSQAERLAQRLRELcpdrvppDFIALH-HGSLSRELREEVEAALKRGDLKVVVATSSLEL 106
|
90 100 110
....*....|....*....|....*....|....*.
gi 750537477 290 GVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDGTPA 325
Cdd:cd18796 107 GIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGAA 142
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
231-325 |
4.74e-12 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 64.20 E-value: 4.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 231 IVYCGTRAKTETLAQALREAGHSACH-------YHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHAD 303
Cdd:cd18797 39 IVFCRSRKLAELLLRYLKARLVEEGPlaskvasYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAG 118
|
90 100
....*....|....*....|..
gi 750537477 304 LPKSIEGYYQEIGRAGRDGTPA 325
Cdd:cd18797 119 YPGSLASLWQQAGRAGRRGKDS 140
|
|
| HRDC |
smart00341 |
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ... |
526-590 |
3.09e-11 |
|
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.
Pssm-ID: 128635 [Multi-domain] Cd Length: 81 Bit Score: 59.62 E-value: 3.09e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 750537477 526 LLSALKAKRRAFAEAARVPAYVIFNDKTLIEMAETRPADLDAFARISGVGAKKLESFGAAFLEVI 590
Cdd:smart00341 7 LLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVI 71
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
225-320 |
5.11e-11 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 66.07 E-value: 5.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 225 HRDQAgIVYCGTRAKTETLAQALreaGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKP---------- 294
Cdd:COG1202 426 YRGQT-IIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPasqvifdsla 501
|
90 100
....*....|....*....|....*..
gi 750537477 295 -DIRWVahadlpkSIEGYYQEIGRAGR 320
Cdd:COG1202 502 mGIEWL-------SVQEFHQMLGRAGR 521
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
231-341 |
5.15e-11 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 65.57 E-value: 5.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 231 IVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEG 310
Cdd:PTZ00110 381 LIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIED 460
|
90 100 110
....*....|....*....|....*....|.
gi 750537477 311 YYQEIGRAGRDGTPADTLTLYGPDDIRFRRQ 341
Cdd:PTZ00110 461 YVHRIGRTGRAGAKGASYTFLTPDKYRLARD 491
|
|
| Rnd |
COG0349 |
Ribonuclease D [Translation, ribosomal structure and biogenesis]; |
526-678 |
1.52e-09 |
|
Ribonuclease D [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440118 [Multi-domain] Cd Length: 365 Bit Score: 60.27 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 526 LLSALKAKRRAFAEAARVPAYVIFNDKTLIEMAETRPADLDAFARISGVGAKKLESFGAAFLEVINGA---PTPEL-HPT 601
Cdd:COG0349 212 VLRELAAWREREARKRDVPRNRVLKDEALLELARRQPKSLEELARLRGLSPGEIRRHGEELLAAVAEAlalPEEELpEPP 291
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 750537477 602 RRKLAGRDSGALYDQLLEAQANLSRgPEGYDKPLSCSASLIAKVAEvkpSDPNSMARLLGDRRAERFGEAFLNVLRA 678
Cdd:COG0349 292 RRLPLSPGYKALLKLLKALLKEVAE-ELGVAPELLASRKDLEALAR---WGELADPPLLSGWRRELFGEELLALLEG 364
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
230-322 |
1.67e-09 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 60.34 E-value: 1.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 230 GIVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIE 309
Cdd:PRK11192 248 SIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSAD 327
|
90
....*....|...
gi 750537477 310 GYYQEIGRAGRDG 322
Cdd:PRK11192 328 TYLHRIGRTGRAG 340
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
231-322 |
3.52e-09 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 56.02 E-value: 3.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 231 IVYCGTRAKTETLAQALREAG-HsachyHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKP---------DIRWVA 300
Cdd:cd18795 47 LVFCSSRKECEKTAKDLAGIAfH-----HAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPartviikgtQRYDGK 121
|
90 100
....*....|....*....|..
gi 750537477 301 HADLPKSIEgYYQEIGRAGRDG 322
Cdd:cd18795 122 GYRELSPLE-YLQMIGRAGRPG 142
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
21-140 |
1.10e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 55.28 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 21 QRDIVDAVCAGKNTLAIMPTGGGKSLCFQLP---ALARDGLT--VVISPLIALMRDQVRAMRA------AGVQAGALTsG 89
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPileALLRDPGSraLYLYPTKALAQDQLRSLRElleqlgLGIRVATYD-G 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 750537477 90 NTEEET---------DMVF---DALHAGTLKLLYIAPERLASTgtrdmltragcTMIAVDEAH 140
Cdd:cd17923 84 DTPREErraiirnppRILLtnpDMLHYALLPHHDRWARFLRNL-----------RYVVLDEAH 135
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
13-322 |
1.13e-08 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 58.32 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 13 GFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPAL------ARDGLTVVISPLIAL-------MRDQVRAMRaa 79
Cdd:PRK11634 25 GYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLhnldpeLKAPQILVLAPTRELavqvaeaMTDFSKHMR-- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 80 GVQAGALTSGnteEETDMVFDALHAGTlKLLYIAPERLASTGTRDMLTRAGCTMIAVDEAHcvsqwghdfrpDYLRIGEL 159
Cdd:PRK11634 103 GVNVVALYGG---QRYDVQLRALRQGP-QIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEAD-----------EMLRMGFI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 160 RRALN----VPLAAFTATADAETREEI--VTRLFDGVQPETFMQG--FDRPNLNLAFEVKDGPRRQ--ILDFAAAHRDQA 229
Cdd:PRK11634 168 EDVETimaqIPEGHQTALFSATMPEAIrrITRRFMKEPQEVRIQSsvTTRPDISQSYWTVWGMRKNeaLVRFLEAEDFDA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 230 GIVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIE 309
Cdd:PRK11634 248 AIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSE 327
|
330
....*....|...
gi 750537477 310 GYYQEIGRAGRDG 322
Cdd:PRK11634 328 SYVHRIGRTGRAG 340
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
263-331 |
2.84e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 48.47 E-value: 2.84e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 750537477 263 KDDRREVERRFSqedglVVVATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDGTPADTLTLY 331
Cdd:cd18785 13 IEHAEEIASSLE-----ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVILF 76
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
31-140 |
1.25e-06 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 48.73 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 31 GKNTLAIMPTGGGKSLCFQLPALAR------DGLTVV-ISPLIALMRDQVRAMRAA--GVQAG---ALTSGNT--EEETD 96
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSladepeKGVQVLyISPLKALINDQERRLEEPldEIDLEipvAVRHGDTsqSEKAK 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 750537477 97 MVFDALHagtlkLLYIAPERLA----STGTRDMLtrAGCTMIAVDEAH 140
Cdd:cd17922 81 QLKNPPG-----ILITTPESLElllvNKKLRELF--AGLRYVVVDEIH 121
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
17-144 |
2.02e-06 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 48.41 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 17 FRPGQRDIVDAV-CAGKNTLAIMPTGGGKSLCFQLPALAR----DGLTVVISPLIAL----MRDQVRAMRAAGVQAGALT 87
Cdd:cd17921 2 LNPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAILRAlatsGGKAVYIAPTRALvnqkEADLRERFGPLGKNVGLLT 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 750537477 88 SgnteeetDMVFDALHAGTLKLLYIAPERLastgtrDMLTRAG-------CTMIAVDEAHCVSQ 144
Cdd:cd17921 82 G-------DPSVNKLLLAEADILVATPEKL------DLLLRNGgerliqdVRLVVVDEAHLIGD 132
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
209-319 |
2.66e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 47.57 E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 209 EVKDGPRRQILDFAAAHRdqAGIVYCGTRAKTETLAQALRE-------AGHSACHyHGGMDKDDRREVERRFSQEDGLVV 281
Cdd:PRK13767 268 EISEALYETLHELIKEHR--TTLIFTNTRSGAERVLYNLRKrfpeeydEDNIGAH-HSSLSREVRLEVEEKLKRGELKVV 344
|
90 100 110
....*....|....*....|....*....|....*...
gi 750537477 282 VATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAG 319
Cdd:PRK13767 345 VSSTSLELGIDIGYIDLVVLLGSPKSVSRLLQRIGRAG 382
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
231-330 |
8.66e-05 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 45.71 E-value: 8.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 231 IVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEG 310
Cdd:PRK04537 261 MVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAED 340
|
90 100
....*....|....*....|
gi 750537477 311 YYQEIGRAGRDGTPADTLTL 330
Cdd:PRK04537 341 YVHRIGRTARLGEEGDAISF 360
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
17-140 |
4.04e-04 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 41.14 E-value: 4.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 17 FRPGQRDIVDAVCAGKNT---LAIMPTGGGKSLC-FQLPALARDGLTVVISPLIALMRDQVRAMRAAGVQA--GALTSGN 90
Cdd:cd17926 1 LRPYQEEALEAWLAHKNNrrgILVLPTGSGKTLTaLALIAYLKELRTLIVVPTDALLDQWKERFEDFLGDSsiGLIGGGK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 750537477 91 TEEETDMVFDalhAGTLKLLYIAPERLASTGTRDMLtragctMIaVDEAH 140
Cdd:cd17926 81 KKDFDDANVV---VATYQSLSNLAEEEKDLFDQFGL------LI-VDEAH 120
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
136-284 |
7.65e-04 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 42.76 E-value: 7.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 136 VDEAHcvsqwghDFRPDYLRIgeLRRALNVpLAAF-------TAT-------ADAETREEIVTrlfDGVQPETFMQGFDR 201
Cdd:COG1203 274 LDEVQ-------AYPPYMLAL--LLRLLEW-LKNLggsvilmTATlppllreELLEAYELIPD---EPEELPEYFRAFVR 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 202 PNLnlafEVKDGP--RRQILDF--AAAHRDQAGIVYCGTRAKTETLAQALREAGHS--ACHYHGGMDKDDRREVER---- 271
Cdd:COG1203 341 KRV----ELKEGPlsDEELAELilEALHKGKSVLVIVNTVKDAQELYEALKEKLPDeeVYLLHSRFCPADRSEIEKeike 416
|
170
....*....|...
gi 750537477 272 RFSQEDGLVVVAT 284
Cdd:COG1203 417 RLERGKPCILVST 429
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
231-335 |
1.00e-03 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 42.21 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 231 IVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEG 310
Cdd:PRK01297 339 MVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDD 418
|
90 100
....*....|....*....|....*
gi 750537477 311 YYQEIGRAGRDGTPADTLTLYGPDD 335
Cdd:PRK01297 419 YVHRIGRTGRAGASGVSISFAGEDD 443
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
241-322 |
1.39e-03 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 41.79 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 241 ETLAQALReagHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKP-------DI-RWVAHADLPKSIEGYY 312
Cdd:PRK01172 278 DSLNEMLP---HGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLParlvivrDItRYGNGGIRYLSNMEIK 354
|
90
....*....|
gi 750537477 313 QEIGRAGRDG 322
Cdd:PRK01172 355 QMIGRAGRPG 364
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
231-322 |
1.59e-03 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 39.38 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 231 IVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDG--LVVVATIAFGMGV-----DKpdirwVAHAD 303
Cdd:cd18793 31 LIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDirVFLLSTKAGGVGLnltaaNR-----VILYD 105
|
90 100
....*....|....*....|.
gi 750537477 304 LP--KSIEgyYQEIGRAGRDG 322
Cdd:cd18793 106 PWwnPAVE--EQAIDRAHRIG 124
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
218-377 |
1.84e-03 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 41.83 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 218 ILDFAAAHRdqAGIVYCGTRAKTETLAQALREA-----------GHSACHY----------------------HGGMDKD 264
Cdd:PRK09751 237 ILDEVLRHR--STIVFTNSRGLAEKLTARLNELyaarlqrspsiAVDAAHFestsgatsnrvqssdvfiarshHGSVSKE 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 265 DRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSIEGYYQEIGRAGRDGTPADTLTLYGpddiRFRRQQID 344
Cdd:PRK09751 315 QRAITEQALKSGELRCVVATSSLELGIDMGAVDLVIQVATPLSVASGLQRIGRAGHQVGGVSKGLFFP----RTRRDLVD 390
|
170 180 190
....*....|....*....|....*....|...
gi 750537477 345 EGLAPDdrkaadharlNALLGLAEALECRRKPL 377
Cdd:PRK09751 391 SAVIVE----------CMFAGRLENLTPPHNPL 413
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
225-320 |
5.62e-03 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 37.15 E-value: 5.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 225 HRDQAGIVYCGTRAKTETLAQALREAGHSACHYHGG--MDKDDRREVERRFSQEDGLVVVATIA-FGMGVDKPDIRWVAH 301
Cdd:cd18799 4 YVEIKTLIFCVSIEHAEFMAEAFNEAGIDAVALNSDysDRERGDEALILLFFGELKPPILVTVDlLTTGVDIPEVDNVVF 83
|
90
....*....|....*....
gi 750537477 302 ADLPKSIEGYYQEIGRAGR 320
Cdd:cd18799 84 LRPTESRTLFLQMLGRGLR 102
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
13-340 |
5.74e-03 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 39.79 E-value: 5.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 13 GFDAFRPGQRDIVDAVCAGKNTLAIMPTGGGKSLCFQLPALARdgltVVISPLIALMRDQVRAM-----RAAGVQAGAlt 87
Cdd:PRK10590 20 GYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQH----LITRQPHAKGRRPVRALiltptRELAAQIGE-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 88 sgNTEEETD-------MVFDALHA--------GTLKLLYIAPERLASTGTRDMLTRAGCTMIAVDEAHCVSQWG--HDFR 150
Cdd:PRK10590 94 --NVRDYSKylnirslVVFGGVSInpqmmklrGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGfiHDIR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 151 PDYLRIGELRRALnvplaAFTATADAETREEIVTRLFDGVQPETFMQGFDRPNLNLAFEVKDGPR-RQILDFAAAHRD-Q 228
Cdd:PRK10590 172 RVLAKLPAKRQNL-----LFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRkRELLSQMIGKGNwQ 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750537477 229 AGIVYCGTRAKTETLAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVVATIAFGMGVDKPDIRWVAHADLPKSI 308
Cdd:PRK10590 247 QVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVP 326
|
330 340 350
....*....|....*....|....*....|..
gi 750537477 309 EGYYQEIGRAGRDGTPADTLTLYGPDDIRFRR 340
Cdd:PRK10590 327 EDYVHRIGRTGRAAATGEALSLVCVDEHKLLR 358
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
243-282 |
8.44e-03 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 39.44 E-value: 8.44e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 750537477 243 LAQALREAGHSACHYHGGMDKDDRREVERRFSQEDGLVVV 282
Cdd:COG0553 565 LEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVF 604
|
|
| |
