oxoglutarate dehydrogenase inhibitor Odhl;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237   1 MSENDRDFEAPVETTSVFREEFINELDAGTSTSsePADTGVERLAPGTALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDI 80
Cdd:NF041660   1 MSDNTGIPEAQVETTSVFRADLLKEMESGAAAA--PADSGAENLPAGAALLVVKRGPNAGARFLLDQPVTTAGRHPESDI 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 737749237  81 FLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTASLSNGDEVQIGKFRLVFLSGP 143
Cdd:NF041660  79 FLDDVTVSRRHAEFRITEGSFEVVDVGSLNGTYVNREPRNSQVLSTGDEVQIGKFRLVFLAGP 141

oxoglutarate dehydrogenase inhibitor Odhl;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237   1 MSENDRDFEAPVETTSVFREEFINELDAGTSTSsePADTGVERLAPGTALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDI 80
Cdd:NF041660   1 MSDNTGIPEAQVETTSVFRADLLKEMESGAAAA--PADSGAENLPAGAALLVVKRGPNAGARFLLDQPVTTAGRHPESDI 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 737749237  81 FLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTASLSNGDEVQIGKFRLVFLSGP 143
Cdd:NF041660  79 FLDDVTVSRRHAEFRITEGSFEVVDVGSLNGTYVNREPRNSQVLSTGDEVQIGKFRLVFLAGP 141

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  48 TALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDT-ASLSN 126
Cdd:COG1716    1 MARLVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVTEpAPLRD 80

                         90
                 ....*....|....*.
gi 737749237 127 GDEVQIGKFRLVFLSG 142
Cdd:COG1716   81 GDVIRLGKTELRFRLS 96

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 737749237    70 TSAGRHP-DSDIFLDDVTVSRRHAEFRL-GDNEFQVVDVGSLNGTYVNREPV 119
Cdd:smart00240   1 VTIGRSSeDCDIQLDGPSISRRHAVIVYdGGGRFYLIDLGSTNGTFVNGKRI 52

oxoglutarate dehydrogenase inhibitor Odhl;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237   1 MSENDRDFEAPVETTSVFREEFINELDAGTSTSsePADTGVERLAPGTALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDI 80
Cdd:NF041660   1 MSDNTGIPEAQVETTSVFRADLLKEMESGAAAA--PADSGAENLPAGAALLVVKRGPNAGARFLLDQPVTTAGRHPESDI 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 737749237  81 FLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTASLSNGDEVQIGKFRLVFLSGP 143
Cdd:NF041660  79 FLDDVTVSRRHAEFRITEGSFEVVDVGSLNGTYVNREPRNSQVLSTGDEVQIGKFRLVFLAGP 141

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  49 ALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTASLSNGD 128
Cdd:cd22684    2 ALLVVRRGPNAGARFLLDQDVTTAGRHPESDIFLDDVTVSRRHAEFRRAEGGFVVRDVGSLNGTYVNRERIDSAVLRNGD 81

                         90
                 ....*....|...
gi 737749237 129 EVQIGKFRLVFLS 141
Cdd:cd22684   82 EVQIGKFRLVFFA 94

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  48 TALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDT-ASLSN 126
Cdd:COG1716    1 MARLVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVTEpAPLRD 80

                         90
                 ....*....|....*.
gi 737749237 127 GDEVQIGKFRLVFLSG 142
Cdd:COG1716   81 GDVIRLGKTELRFRLS 96

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaB and similar proteins; FhaB, also called FtsZ-interacting protein A (FipA), is a putative virulence factor involved in regulating cell shape. It can interact with polyketide-associated protein PapA5, a putative membrane protein involved in the biosynthesis of virulence enhancing lipids. FhaB regulates growth and cell division. It is probably required for divisomal protein assembly under oxidative stress. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  51 LVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTA-SLSNGDE 129
Cdd:cd22693    1 LVIIEGTLQGQTFPIDKSGITIGRADDNDLVLSDDFVSSRHARIYLQGSSWYLEDLGSTNGTFVNGNRVTQPvVVQPGDT 80

                 ....*
gi 737749237 130 VQIGK 134
Cdd:cd22693   81 IRIGA 85

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  50 LLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEF-RLGDnEFQVVDVGSLNGTYVNREPVDTASLSNGD 128
Cdd:cd22698    3 ILIEQKGSEEGKDYELDQDEFTIGRSSNNDIRLNDHSVSRHHARIvRQGD-KCNLTDLGSTNGTFLNGIRVGTHELKHGD 81

                         90
                 ....*....|..
gi 737749237 129 EVQIGKFRLVFL 140
Cdd:cd22698   82 RIQLGETIFRFI 93

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237   53 VKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVD--TASLSNGDEV 130
Cdd:pfam16697   2 VLSGPHAGAEFPLEGGRYRIGSDPDCDIVLSDKEVSRVHLKLEVDDEGWRLDDLGSGNGTLVNGQRVTelGIALRPGDRI 81

                  ....*....
gi 737749237  131 QIGKFRLVF 139
Cdd:pfam16697  82 ELGQTEFCL 90

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737749237  58 NAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTASLSNGDEVQIGK 134
Cdd:cd22694    6 PGGELRFDPGSSVRIGRDPDADVRLDDPRVSRRHALLEFDGDGWVYTDLGSRNGTYLNGRRVQQVKLSDGTRVRLGD 82

second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the second FHA domain, which has a circularly permuted FHA domain fold with a conserved pThr-binding interface.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  48 TALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTASLSNG 127
Cdd:cd22737    1 TPMMKITRPDGDTLTFELPPQAVRIGRASDNDIVIPEGSVSRHHATLVPTPGGTQIRDLRSTNGTFVNGLRVDAALLHDG 80

                         90
                 ....*....|..
gi 737749237 128 DEVQIGKFRLVF 139
Cdd:cd22737   81 DVVTIGDIDFVF 92

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  51 LVVKRGPN--AGSRFLLDQPTTSAGRHPD--SDIFLDDVTVSRRHAEFRLGDNE--FQVVDVGSLNGTYVNREPV----- 119
Cdd:cd22686    7 VIVVESPSlqVGSLFIVTATGATIGREKDhgHTIRIPELGVSKFHAEIYYDDDEqsYTIVDLGSQNGTYLNGVRIsqpke 86

                         90       100
                 ....*....|....*....|..
gi 737749237 120 --DTASLSNGDEVQIGKFRLVF 139
Cdd:cd22686   87 ksDPYPLTHGDELKIGETTLLF 108

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  51 LVVKRGPN-AGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVN--REPVDTASLSNG 127
Cdd:cd22680    3 LEILSSPNlTGKKFPFDFSSVSIGRDPENVIVIPDPFVSRNHARITVDSNEIYIEDLGSTNGTFVNdfKRIKGPAKLHPN 82

                 ....*..
gi 737749237 128 DEVQIGK 134
Cdd:cd22680   83 DIIKLGR 89

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  50 LLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNR----EPVDTASLS 125
Cdd:cd22665    3 LKVFSQAHGPEKDFPLYEGENVIGRDPSCSVVLPDKSVSKQHACIEVDGGTHLIEDLGSTNGTRIGNkvrlKPNVRYELI 82

                         90
                 ....*....|....*
gi 737749237 126 NGDEVQIGKFRLVFL 140
Cdd:cd22665   83 DGDLLLFGDVKCQYV 97

forkhead associated (FHA) domain found in Synechocystis sp. Slr1951 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Synechocystis sp. protein Slr1951 and protein Sll1895. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  51 LVVKRGPNAGSRfLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFR-----LGDNEFQVVD-----VGSLNGTYVNREPVD 120
Cdd:cd22697    2 LVELDGNVRREI-RLDEPIYTIGRHPGNDIQIPSQQISRRHATLRrkinpNLDISFWIIDgdlegAESLNGLWVNGERIL 80

                         90
                 ....*....|...
gi 737749237 121 TASLSNGDEVQIG 133
Cdd:cd22697   81 QHELVNGDEIALG 93

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 737749237  73 GRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTA-SLSNGDEVQIG 133
Cdd:cd22668   23 GRGSDADFRLPDTGVSRRHAEIRWDGQVAHLTDLGSTNGTTVNNAPVTPEwRLADGDVITLG 84

forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; RNF8 is a telomere-associated E3 ubiquitin-protein ligase that plays an important role in DNA double-strand break (DSB) repair via histone ubiquitination. It is localized in the nucleus and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3), but not with other E2s (UbcH5, UbcH7, UbcH10, hCdc34, and hBendless). It recruits UBC13 for lysine 63-based self polyubiquitylation. Its deficiency causes neuronal pathology and cognitive decline, and its loss results in neuron degeneration. RNF8, together with RNF168, catalyzes a series of ubiquitylation events on substrates such as H2A and H2AX, with the H2AK13/15 ubiquitylation being particularly important for recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of DSBs. Specially, RNF8 mediates the ubiquitination of gammaH2AX, and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DNA damage response (DDR) and inhibits chromosomal instability. Moreover, RNF8 interacts with retinoid X receptor alpha (RXR alpha) and enhances its transcription-stimulating activity. It also regulates the rate of exit from mitosis and cytokinesis. RNF8 contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  57 PNAGSRFLL-DQPTTSAGRHPDS--DIFLDD-VTVSRRHAEFRLGD-NEFQVVDVGSLNGTYVNRE---PVDTASLSNGD 128
Cdd:cd22663    9 GIDPLVLLLeDGKEVTVGRGLGVtyQLVSTCpLMISRNHCVLKKNDeGQWTIKDNKSLNGVWVNGEriePLKPYPLNEGD 88

                 ....*.
gi 737749237 129 EVQIGK 134
Cdd:cd22663   89 LIQLGV 94

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  56 GPNAGSRFLLDQPTTSAGRhPDSDI-FLDDVTVSRRHAEFRLGDNE-----------FQVVDVgSLNGTYVNREPV---D 120
Cdd:cd22667    8 DGAGTSYYLLPGGEYTVGR-KDCDIiIVDDSSISRKHATLTVLHPEanlsdpdtrpeLTLKDL-SKYGTFVNGEKLkggS 85

                         90       100
                 ....*....|....*....|...
gi 737749237 121 TASLSNGDEVQIG----KFRLVF 139
Cdd:cd22667   86 EVTLKDGDVITFGvlgsKFRVEY 108

first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the first one. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 737749237  73 GRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDV----GSLNGTYVNREPVDTAS---LSNGDEVQIG 133
Cdd:cd22689   50 GRHPACDYHLGNSRLSNKHFQILLGESDPSDGNVllndISSNGTWLNGQRLEKNSnqlLSQGDEITIG 117

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  61 SRFLLDQPTTSAGRHP-DSDIFLDDVT----VSRRHAEFRLGDNEFQVVDVG----SLNGTYVN--REPVDTA-SLSNGD 128
Cdd:cd22685   21 YTFRPDLCEYRIGRNPeVCDVFLCSSQhpnlISREHAEIHAERDGNGNWKVLiedrSTNGTYVNdvRLQDGQRrELSDGD 100

                 ....*.
gi 737749237 129 EVQIGK 134
Cdd:cd22685  101 TITFGH 106

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737749237  73 GRHPD-SDIFLDDVTVSRRHA--EFRLGDNEFQ----------VVDVGSLNGTYVNREPVDTA---SLSNGDEVQIG 133
Cdd:cd22676   26 GRDRRvADIPLDHPSCSKQHAviQFREVEKRNEgdvienirpyIIDLGSTNGTFLNGEKIEPRryyELREKDVLKFG 102

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  68 PTTSAGRHPDSDIFL-DDVTVSRRHA--EFRLGDNEFQVVDVGSlNGTYVNREPV----DTASLSNGDEVQIGKFRLVFL 140
Cdd:cd22701   26 KNSSSTAADSVDIDLgPSKKISRRHAriFYDFTTQCFELSVLGR-NGVKVDGILVkpgsPPVPLRSGSLIQIGGVLFYFL 104

forkhead associated (FHA) domain found in Mycobacterium tuberculosis transcriptional regulatory protein EmbR and similar proteins; EmbR is a transcriptional regulator of the embCAB operon encoding cell wall arabinosyltransferases (EmbC, -A, and -B), and is phosphorylated by the cognate mycobacterial serine/threonine protein kinase PknH. It interacts with RNA polymerase and possesses a phosphorylation-dependent ATPase activity. EmbR contains a regulatory C-terminal forkhead-associated (FHA) domain, which mediates binding to a threonine-phosphorylated site in PknH. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737749237  59 AGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLGDNEFQVVDVGSLNGTYVNREPVDTAS-LSNGDEVQIG 133
Cdd:cd22669    7 SGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSAVtLNDGDHIRIC 82

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  46 PGTALLVVKRGPNAgSRFLLDQPT-TSAGRHPD-SDIFLDDVTVSRRHAEFRL--GDNEFQVVDVGSLNGTYVNR---EP 118
Cdd:cd22674    5 PGLHLDVVKDGKLI-EKLMIDEKKyYLFGRNSDvCDFVLDHPSCSRVHAALVYhkHLNRVFLIDLGSTHGTFVGGirlEP 83

                         90
                 ....*....|....*
gi 737749237 119 VDTASLSNGDEVQIG 133
Cdd:cd22674   84 HKPQQLPIDSTLRFG 98

forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; MCRS1, also called 58 kDa microspherule protein (MSP58), cell cycle-regulated factor p78, or INO80 complex subunit J, is a nuclear RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal ribonucleoparticles (mRNPs) from neurons. It is a cell-cycle-dependent protein that acts as an inhibitor of TERT telomerase activity. It associates with LPTS/PinX1 and reduces the telomere length. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, MCRS1 may be involved in acetylation of nucleosomal histone H4 on several lysine residues. MCRS1 is also a putative regulatory component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication, and probably DNA repair. MCRS1 contains an FHA domain at its C-terminus. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 737749237  87 VSRRHAEFRLGDN-EFQVVDVGSlNGTYVNREPVDT---ASLSNGDEVQIGKFRLVFL 140
Cdd:cd22687   47 ISRRQAVIKLKNDgDFYIKNEGK-RPIYVNGKPVPTgekAILNNNSLIEIGGLRFVFL 103

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa (Cep170) and similar proteins; Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737749237  58 NAGSRFLLDQPTTSAGRHpDSDIFLDDVTVSRRHA--EFRLGDNEFQVVDVGSLNGTYVN--REPVDT-ASLSNGDEVQI 132
Cdd:cd22724   11 SGGTRHRLPREMIFVGRD-DCELMLQSRSVDKQHAviNYDASTDEHKVKDLGSLNGTFVNdvRIPEQTyITLKLDDKLRF 89

                 .
gi 737749237 133 G 133
Cdd:cd22724   90 G 90