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dGTP triphosphohydrolase [Porphyromonas asaccharolytica]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
PRK01096 super family
cl35137 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
1-441
6.01e-150
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
PRK01096 :Pssm-ID: 234897 [Multi-domain]
Cd Length: 440
Bit Score: 433.57
E-value: 6.01e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 1 M N WD Q L I S NR R F G APEPERAGA LG ggmem R TE F DR DYDR L IFS AP FRRLQ N K A Q IF PL P KN IFV H N RLTHSLEVSCVGRS 80
Cdd:PRK01096 1 M D WD T L L S RE R L G KKGKTSKDE LG ----- R SP F HK DYDR I IFS GS FRRLQ R K T Q VH PL A KN DHI H T RLTHSLEVSCVGRS 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 81 LG NYIARR L TDNQD ---- T P H rg S I ATV V SA ACLAHD M GNPPFGH S GE R AIR AY F TEGN GR QWY D AVVGEGH pw E DF AY F 156
Cdd:PRK01096 76 LG MRVGET L KEEKL pdwi S P A -- D I GAI V QS ACLAHD I GNPPFGH F GE D AIR EW F QDAA GR GFL D DLSPQER -- A DF LN F 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 157 EGNA N GFR L LT ---- HQ FE grrp GG FA LTY T TL AAIV KYPWSS AR A PESG ---- KFG YF QSE RATYLDV A NY LG ILPVDP 228
Cdd:PRK01096 152 EGNA Q GFR V LT kley HQ DD ---- GG MR LTY A TL GTYI KYPWSS RH A NKQQ ikkk KFG CY QSE LPLFEQI A EA LG LPQLGE 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 229 as GHYV RHPL V YL V EAADDICY QVM D V ED AYKLRI L S Y ERTVD L L L ryf PAD G HDHVLATMQSIGD R NERI A Y LR A KAI N 308
Cdd:PRK01096 228 -- QRWC RHPL T YL L EAADDICY ALI D L ED GLEMGL L N Y QEVEA L F L --- ELI G DKEKYRQLGPQDS R RQKL A R LR G KAI G 302
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 309 I LV E A C AE V F I E HEEE IL H GT FA G T L VSQMPERLYEAYRANSAV A QSE I YTARAVIDV E LAGHR I FSE L I D KLMHSL L HP 388
Cdd:PRK01096 303 R LV N A V AE A F V E NYDA IL A GT LP G D L IEHCDPDAKRCVQQAKDL A REK I FQHKRKVEL E IGAYT I LEI L L D AFVPAA L YY 382
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 490461253 389 D ----- DAYSRT LL S L VSSQYNLHEESI Y GK L QCT LD Y ISGMTD P YA LD L YRRI TG M S 441
Cdd:PRK01096 383 D sgttp SFKDKR LL D L LGDNAPDPTMKL Y LR L LRV LD F ISGMTD S YA KE L AQEL TG R S 440
Name
Accession
Description
Interval
E-value
PRK01096
PRK01096 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
1-441
6.01e-150
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 234897 [Multi-domain]
Cd Length: 440
Bit Score: 433.57
E-value: 6.01e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 1 M N WD Q L I S NR R F G APEPERAGA LG ggmem R TE F DR DYDR L IFS AP FRRLQ N K A Q IF PL P KN IFV H N RLTHSLEVSCVGRS 80
Cdd:PRK01096 1 M D WD T L L S RE R L G KKGKTSKDE LG ----- R SP F HK DYDR I IFS GS FRRLQ R K T Q VH PL A KN DHI H T RLTHSLEVSCVGRS 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 81 LG NYIARR L TDNQD ---- T P H rg S I ATV V SA ACLAHD M GNPPFGH S GE R AIR AY F TEGN GR QWY D AVVGEGH pw E DF AY F 156
Cdd:PRK01096 76 LG MRVGET L KEEKL pdwi S P A -- D I GAI V QS ACLAHD I GNPPFGH F GE D AIR EW F QDAA GR GFL D DLSPQER -- A DF LN F 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 157 EGNA N GFR L LT ---- HQ FE grrp GG FA LTY T TL AAIV KYPWSS AR A PESG ---- KFG YF QSE RATYLDV A NY LG ILPVDP 228
Cdd:PRK01096 152 EGNA Q GFR V LT kley HQ DD ---- GG MR LTY A TL GTYI KYPWSS RH A NKQQ ikkk KFG CY QSE LPLFEQI A EA LG LPQLGE 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 229 as GHYV RHPL V YL V EAADDICY QVM D V ED AYKLRI L S Y ERTVD L L L ryf PAD G HDHVLATMQSIGD R NERI A Y LR A KAI N 308
Cdd:PRK01096 228 -- QRWC RHPL T YL L EAADDICY ALI D L ED GLEMGL L N Y QEVEA L F L --- ELI G DKEKYRQLGPQDS R RQKL A R LR G KAI G 302
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 309 I LV E A C AE V F I E HEEE IL H GT FA G T L VSQMPERLYEAYRANSAV A QSE I YTARAVIDV E LAGHR I FSE L I D KLMHSL L HP 388
Cdd:PRK01096 303 R LV N A V AE A F V E NYDA IL A GT LP G D L IEHCDPDAKRCVQQAKDL A REK I FQHKRKVEL E IGAYT I LEI L L D AFVPAA L YY 382
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 490461253 389 D ----- DAYSRT LL S L VSSQYNLHEESI Y GK L QCT LD Y ISGMTD P YA LD L YRRI TG M S 441
Cdd:PRK01096 383 D sgttp SFKDKR LL D L LGDNAPDPTMKL Y LR L LRV LD F ISGMTD S YA KE L AQEL TG R S 440
dGTP_triPase
TIGR01353 deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
30-439
9.29e-131
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]
Pssm-ID: 273571 [Multi-domain]
Cd Length: 381
Bit Score: 382.49
E-value: 9.29e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 30 RT E F D RDYDR L I F S AP FRRLQ N K A Q I FPL PK N I FV HN RLTHSLEV SC VGRS LG N Y I AR R LTDNQDTP hr G SIATVVSA AC 109
Cdd:TIGR01353 2 RT P F E RDYDR I I H S SA FRRLQ D K T Q V FPL AE N D FV RT RLTHSLEV AQ VGRS IA N L I GL R YDLELEEL -- G PFERLAET AC 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 110 LAHD M GNPPFGH S GERA IRAYFT E GNGR qwydavvgeghpwedfay FEGNA NG FR L LT HQFEG RR - P GG FA LT YT TLA A I 188
Cdd:TIGR01353 80 LAHD I GNPPFGH A GERA LNDWMR E YGPG ------------------ FEGNA QT FR I LT TLEKR RR a K GG LN LT WR TLA G I 141
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 189 V KYP WS S ARAPES G ----- K F G YFQ SE R A TYLD VA NY LG IL pvdpasgh YV R H PL VY L V EAADDI C Y Q V M D V EDA Y KL RI 263
Cdd:TIGR01353 142 L KYP RP S SEDAFK G gylnk K K G IYD SE L A VFDR VA EL LG LT -------- WY R S PL AQ L M EAADDI A Y T V H D L EDA I KL GL 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 264 L SYERTVD LLL ryf PAD G HDHVLAT M -- Q SI GDR NE R I AY LR A K A I NI L V E AC A E - V F IE H EEE IL H GTF AG TLV SQM P e 340
Cdd:TIGR01353 214 L TFDDLQH LLL --- IQA G FEELGSE M td L SI SAE NE Q I RS LR G K L I TD L I E SV A K a E F SS H LVA IL I GTF HH TLV EFS P - 289
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 341 RL Y E AYR A NSAVAQSEI Y TARA V IDV E LA G HR I FSE L I D KL M HS L lh P DDAYSRT L L S LVSSQ ynlhe E SI Y G K LQCTL D 420
Cdd:TIGR01353 290 RL A E LLE A LKKFLRKRV Y RHPD V ERI E YQ G EQ I ITG L F D AF M PD L -- P PRLLPPE L R S KLRKA ----- E DN Y Y K ARVVC D 362
410
....*....|....*....
gi 490461253 421 YI S GMTD P YAL DL YRR IT G 439
Cdd:TIGR01353 363 YI A GMTD R YAL EE YRR LF G 381
Dgt
COG0232 dGTP triphosphohydrolase [Nucleotide transport and metabolism];
28-438
7.02e-127
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
Pssm-ID: 440002 [Multi-domain]
Cd Length: 345
Bit Score: 371.02
E-value: 7.02e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 28 EM R TE F D RD Y DR L I F SA P FRRLQ N K A Q I FPLP KNIFVHN RLTHSLEV SCVG RS lgny IAR R L TD N Q D tphrgsiat V V S A 107
Cdd:COG0232 2 DI R SP F Q RD R DR I I H SA A FRRLQ D K T Q V FPLP EGDHYRT RLTHSLEV AQIA RS ---- IAR A L GL N E D --------- L V E A 68
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 108 A C LAHD M G N PPFGH S GE R A IRAY F tegngrqwydavvgeghpw E D FAY FEGNA NGF R L LT HQFEGRRP GG FA LTY T TL AA 187
Cdd:COG0232 69 A A LAHD L G H PPFGH A GE D A LNEL F ------------------- R D LGG FEGNA QSL R I LT RLEKRYAF GG LN LTY A TL DG 129
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 188 I V KYP WS S AR AP ESGKF G YF QSE RATYLD V ANY LG I L P vdpas GHYV R HPLVYL VE A ADDI C Y Q V M D V EDA YKLRI LS Y E 267
Cdd:COG0232 130 I L KYP GP S LA AP KPKPK G FY QSE KDVFDW V REE LG L L A ----- LGRP R TLEAQI VE L ADDI A Y S V H D L EDA IRAGL LS L E 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 268 RTVD LL LRYF P A D GH dhvlatmqsigdrn E R IAY LR AKA I NI LV EACA E VFI E HE eeilhgt F A G T L VS q MPERLYE A YR 347
Cdd:COG0232 205 DLPE LL EYLG P L D ER -------------- R R LGE LR SRL I GR LV TDVI E ASR E NL ------- F D G P L IA - FSPEVAA A LK 262
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 348 ANSAVAQSEI Y TARA V IDV EL A G H RI FS EL I D KLMHSL L H pddaysrt LL SLVSSQYNLHEESI YG K L QCTL DYI S GMTD 427
Cdd:COG0232 263 ELKKFLFERV Y RHPE V LRL EL K G R RI IR EL F D AFLEDP L E -------- LL PEEFRERYEAADDE YG R L RVVA DYI A GMTD 334
410
....*....|.
gi 490461253 428 P YAL D LYRR IT 438
Cdd:COG0232 335 R YAL R LYRR LF 345
antiphage_dGTPase
NF041026 anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
3-437
2.95e-50
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.
Pssm-ID: 468955 [Multi-domain]
Cd Length: 426
Bit Score: 175.77
E-value: 2.95e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 3 W DQ lisn RR F G a P E PE R AG algggm EM R TE F D RD YD R L I F SA P FRRLQ N K A Q IFP L PKNI F VHN RLTHSLEV SCV G RS lg 82
Cdd:NF041026 1 W QE ---- RR R G - E E KK R RN ------ DH R SP F Q RD RA R I I H SA A FRRLQ A K T Q VLG L GESD F YRT RLTHSLEV AQI G TG -- 67
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 83 ny I ARR L TDN Q DT P H R GSIA -- TVVS A A CLAHD M G N PPFGH S GE R A IR a Y FTEGN G rqwydavv G eghpwedfay FEGN A 160
Cdd:NF041026 68 -- I VAQ L KAK Q PE P L R ALLP dd SLIE A I CLAHD I G H PPFGH G GE V A LN - Y MMRDH G -------- G ---------- FEGN G 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 161 NGF R L LT h QF E GRRPG - G FA LT YT TL AAIV KYP -- W S SAR AP ESGKF ---------------- GY FQSERATY ------- 214
Cdd:NF041026 127 QTL R I LT - KL E PYTEH h G MN LT RR TL LGVL KYP al Y S QVQ AP QLPPK vsnfrqlkasdwkppk GY YDCDQDVV dwvlapl 205
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 215 -- L D V A NYLGILPVDPASGHYV R HPLV -- YLV E A ADDI C Y Q V M D V EDA YK L RILSY E RTVDLLLRYFP A D G HDHVLATMQ 290
Cdd:NF041026 206 se N D R A LFTSLDEKPGKQHGKT R FKSL dc SIM E L ADDI A Y G V H D L EDA IV L GLVTR E QWQEAVAPKLA A L G DPWLSDNLD 285
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 291 SIG D R --- N E R ia Y L R AK AI NI LV EA caev FI EHE E EILHGT F AGT L VS qmperl Y E A YRANSAV A QS E I --- YTARA VI 364
Cdd:NF041026 286 ELS D K lfs G E H -- Y E R KD AI GA LV NY ---- FI TSI E IKEVDA F EEP L LR ------ Y N A VLPPEVA A LL E V lkq FVYQY VI 353
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 365 D ------ V E LA G HR I FS EL IDK L MH --- S LL h P DDAYS R tllslvssq YNLH EE SIYGKLQCTL DYI S GMTD P YAL D LY R 435
Cdd:NF041026 354 R spevqq L E YK G QQ I VM EL FEA L AS dpe R LL - P ENTRE R --------- WQEA EE DGENGKRVIC DYI A GMTD E YAL R LY Q 423
..
gi 490461253 436 R I 437
Cdd:NF041026 424 R L 425
HD_assoc
pfam13286 Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
420-436
3.29e-04
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.
Pssm-ID: 433087 [Multi-domain]
Cd Length: 91
Bit Score: 39.43
E-value: 3.29e-04
Name
Accession
Description
Interval
E-value
PRK01096
PRK01096 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
1-441
6.01e-150
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 234897 [Multi-domain]
Cd Length: 440
Bit Score: 433.57
E-value: 6.01e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 1 M N WD Q L I S NR R F G APEPERAGA LG ggmem R TE F DR DYDR L IFS AP FRRLQ N K A Q IF PL P KN IFV H N RLTHSLEVSCVGRS 80
Cdd:PRK01096 1 M D WD T L L S RE R L G KKGKTSKDE LG ----- R SP F HK DYDR I IFS GS FRRLQ R K T Q VH PL A KN DHI H T RLTHSLEVSCVGRS 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 81 LG NYIARR L TDNQD ---- T P H rg S I ATV V SA ACLAHD M GNPPFGH S GE R AIR AY F TEGN GR QWY D AVVGEGH pw E DF AY F 156
Cdd:PRK01096 76 LG MRVGET L KEEKL pdwi S P A -- D I GAI V QS ACLAHD I GNPPFGH F GE D AIR EW F QDAA GR GFL D DLSPQER -- A DF LN F 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 157 EGNA N GFR L LT ---- HQ FE grrp GG FA LTY T TL AAIV KYPWSS AR A PESG ---- KFG YF QSE RATYLDV A NY LG ILPVDP 228
Cdd:PRK01096 152 EGNA Q GFR V LT kley HQ DD ---- GG MR LTY A TL GTYI KYPWSS RH A NKQQ ikkk KFG CY QSE LPLFEQI A EA LG LPQLGE 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 229 as GHYV RHPL V YL V EAADDICY QVM D V ED AYKLRI L S Y ERTVD L L L ryf PAD G HDHVLATMQSIGD R NERI A Y LR A KAI N 308
Cdd:PRK01096 228 -- QRWC RHPL T YL L EAADDICY ALI D L ED GLEMGL L N Y QEVEA L F L --- ELI G DKEKYRQLGPQDS R RQKL A R LR G KAI G 302
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 309 I LV E A C AE V F I E HEEE IL H GT FA G T L VSQMPERLYEAYRANSAV A QSE I YTARAVIDV E LAGHR I FSE L I D KLMHSL L HP 388
Cdd:PRK01096 303 R LV N A V AE A F V E NYDA IL A GT LP G D L IEHCDPDAKRCVQQAKDL A REK I FQHKRKVEL E IGAYT I LEI L L D AFVPAA L YY 382
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 490461253 389 D ----- DAYSRT LL S L VSSQYNLHEESI Y GK L QCT LD Y ISGMTD P YA LD L YRRI TG M S 441
Cdd:PRK01096 383 D sgttp SFKDKR LL D L LGDNAPDPTMKL Y LR L LRV LD F ISGMTD S YA KE L AQEL TG R S 440
dGTP_triPase
TIGR01353 deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
30-439
9.29e-131
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]
Pssm-ID: 273571 [Multi-domain]
Cd Length: 381
Bit Score: 382.49
E-value: 9.29e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 30 RT E F D RDYDR L I F S AP FRRLQ N K A Q I FPL PK N I FV HN RLTHSLEV SC VGRS LG N Y I AR R LTDNQDTP hr G SIATVVSA AC 109
Cdd:TIGR01353 2 RT P F E RDYDR I I H S SA FRRLQ D K T Q V FPL AE N D FV RT RLTHSLEV AQ VGRS IA N L I GL R YDLELEEL -- G PFERLAET AC 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 110 LAHD M GNPPFGH S GERA IRAYFT E GNGR qwydavvgeghpwedfay FEGNA NG FR L LT HQFEG RR - P GG FA LT YT TLA A I 188
Cdd:TIGR01353 80 LAHD I GNPPFGH A GERA LNDWMR E YGPG ------------------ FEGNA QT FR I LT TLEKR RR a K GG LN LT WR TLA G I 141
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 189 V KYP WS S ARAPES G ----- K F G YFQ SE R A TYLD VA NY LG IL pvdpasgh YV R H PL VY L V EAADDI C Y Q V M D V EDA Y KL RI 263
Cdd:TIGR01353 142 L KYP RP S SEDAFK G gylnk K K G IYD SE L A VFDR VA EL LG LT -------- WY R S PL AQ L M EAADDI A Y T V H D L EDA I KL GL 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 264 L SYERTVD LLL ryf PAD G HDHVLAT M -- Q SI GDR NE R I AY LR A K A I NI L V E AC A E - V F IE H EEE IL H GTF AG TLV SQM P e 340
Cdd:TIGR01353 214 L TFDDLQH LLL --- IQA G FEELGSE M td L SI SAE NE Q I RS LR G K L I TD L I E SV A K a E F SS H LVA IL I GTF HH TLV EFS P - 289
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 341 RL Y E AYR A NSAVAQSEI Y TARA V IDV E LA G HR I FSE L I D KL M HS L lh P DDAYSRT L L S LVSSQ ynlhe E SI Y G K LQCTL D 420
Cdd:TIGR01353 290 RL A E LLE A LKKFLRKRV Y RHPD V ERI E YQ G EQ I ITG L F D AF M PD L -- P PRLLPPE L R S KLRKA ----- E DN Y Y K ARVVC D 362
410
....*....|....*....
gi 490461253 421 YI S GMTD P YAL DL YRR IT G 439
Cdd:TIGR01353 363 YI A GMTD R YAL EE YRR LF G 381
Dgt
COG0232 dGTP triphosphohydrolase [Nucleotide transport and metabolism];
28-438
7.02e-127
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
Pssm-ID: 440002 [Multi-domain]
Cd Length: 345
Bit Score: 371.02
E-value: 7.02e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 28 EM R TE F D RD Y DR L I F SA P FRRLQ N K A Q I FPLP KNIFVHN RLTHSLEV SCVG RS lgny IAR R L TD N Q D tphrgsiat V V S A 107
Cdd:COG0232 2 DI R SP F Q RD R DR I I H SA A FRRLQ D K T Q V FPLP EGDHYRT RLTHSLEV AQIA RS ---- IAR A L GL N E D --------- L V E A 68
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 108 A C LAHD M G N PPFGH S GE R A IRAY F tegngrqwydavvgeghpw E D FAY FEGNA NGF R L LT HQFEGRRP GG FA LTY T TL AA 187
Cdd:COG0232 69 A A LAHD L G H PPFGH A GE D A LNEL F ------------------- R D LGG FEGNA QSL R I LT RLEKRYAF GG LN LTY A TL DG 129
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 188 I V KYP WS S AR AP ESGKF G YF QSE RATYLD V ANY LG I L P vdpas GHYV R HPLVYL VE A ADDI C Y Q V M D V EDA YKLRI LS Y E 267
Cdd:COG0232 130 I L KYP GP S LA AP KPKPK G FY QSE KDVFDW V REE LG L L A ----- LGRP R TLEAQI VE L ADDI A Y S V H D L EDA IRAGL LS L E 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 268 RTVD LL LRYF P A D GH dhvlatmqsigdrn E R IAY LR AKA I NI LV EACA E VFI E HE eeilhgt F A G T L VS q MPERLYE A YR 347
Cdd:COG0232 205 DLPE LL EYLG P L D ER -------------- R R LGE LR SRL I GR LV TDVI E ASR E NL ------- F D G P L IA - FSPEVAA A LK 262
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 348 ANSAVAQSEI Y TARA V IDV EL A G H RI FS EL I D KLMHSL L H pddaysrt LL SLVSSQYNLHEESI YG K L QCTL DYI S GMTD 427
Cdd:COG0232 263 ELKKFLFERV Y RHPE V LRL EL K G R RI IR EL F D AFLEDP L E -------- LL PEEFRERYEAADDE YG R L RVVA DYI A GMTD 334
410
....*....|.
gi 490461253 428 P YAL D LYRR IT 438
Cdd:COG0232 335 R YAL R LYRR LF 345
dgt
PRK04926 deoxyguanosinetriphosphate triphosphohydrolase; Provisional
5-440
5.58e-81
deoxyguanosinetriphosphate triphosphohydrolase; Provisional
Pssm-ID: 235320 [Multi-domain]
Cd Length: 503
Bit Score: 258.70
E-value: 5.58e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 5 QL I SN - RR FGA P EPER agalg GGM E MRTE F DR D YD R L I F SA PF RRLQ N K A Q I FPL PK N IF V HN RLTHSLEV SC VGR slgn 83
Cdd:PRK04926 8 KK I NW q RR YRS P QGVK ----- TEH E ILRI F ES D RG R I I N SA AI RRLQ Q K T Q V FPL ER N AA V RS RLTHSLEV QQ VGR ---- 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 84 YIA R ---- RL TDNQD ------ TPHR G SIATV V SA ACL A HD M GNPPFGH S GE R AI RAY F TE ------- GNGRQWYDAV V GE 146
Cdd:PRK04926 79 YIA K eils RL KEQKL leaygl DELT G PFESI V EM ACL M HD I GNPPFGH F GE A AI NDW F RQ rldpdae SQPLTDDRCS V AA 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 147 GHPWE -------------- D FAY FEGNA N G F RL LTHQF egrrpg GFA LTY TTL A A I V KY P ---- W SSARAPESG ---- K F 204
Cdd:PRK04926 159 LRLRD geeplnelrrkirq D LCH FEGNA Q G I RL VHTLL ------ RLN LTY AQV A C I L KY T rpaw W RGPTPASHH ylmk K P 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 205 GY FQ SE R A TYLDVANY L GIL P vdpasgh Y V R H PL V Y LV EAADDI C Y QVM D V EDA YKL RI L S Y E RTVDL L LRYFPADGHDH 284
Cdd:PRK04926 233 GY YL SE E A YVARLRKE L NLA P ------- Y S R F PL T Y IM EAADDI S Y CIA D L EDA VEK RI F S V E QLYHH L HEAWGEHEKGD 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 285 VLATM ---------- Q S IGDRN E RI -- A YLR AKAI N I LV EAC A EV FI EHEEE I LH GTF AGT L VSQMPE -- RL YEAYR ans 350
Cdd:PRK04926 306 LFSLV venaweksra N S LSRSS E DQ ff M YLR VNTL N K LV PYA A QR FI DNLPA I FA GTF NQA L LEDASP as RL LKTFK --- 382
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 351 A VA QSEIYTARA V IDV EL A G H R IF S E L I D k LMHS LL --------------- H PDDAYSRT L LSLV S SQYN L HEESIYG KL 415
Cdd:PRK04926 383 N VA RKHVFSHPE V EQL EL Q G Y R VI S G L L D - IYSP LL alpledftelveker H KRYPIETR L FHKL S TRHR L AYVEAVS KL 461
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 490461253 416 QCT ---------------- L DYISGMTD P YA L D L YRR ITGM 440
Cdd:PRK04926 462 PSD spefplweyyyrarli Q DYISGMTD L YA W D E YRR LMAV 502
antiphage_dGTPase
NF041026 anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
3-437
2.95e-50
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.
Pssm-ID: 468955 [Multi-domain]
Cd Length: 426
Bit Score: 175.77
E-value: 2.95e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 3 W DQ lisn RR F G a P E PE R AG algggm EM R TE F D RD YD R L I F SA P FRRLQ N K A Q IFP L PKNI F VHN RLTHSLEV SCV G RS lg 82
Cdd:NF041026 1 W QE ---- RR R G - E E KK R RN ------ DH R SP F Q RD RA R I I H SA A FRRLQ A K T Q VLG L GESD F YRT RLTHSLEV AQI G TG -- 67
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 83 ny I ARR L TDN Q DT P H R GSIA -- TVVS A A CLAHD M G N PPFGH S GE R A IR a Y FTEGN G rqwydavv G eghpwedfay FEGN A 160
Cdd:NF041026 68 -- I VAQ L KAK Q PE P L R ALLP dd SLIE A I CLAHD I G H PPFGH G GE V A LN - Y MMRDH G -------- G ---------- FEGN G 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 161 NGF R L LT h QF E GRRPG - G FA LT YT TL AAIV KYP -- W S SAR AP ESGKF ---------------- GY FQSERATY ------- 214
Cdd:NF041026 127 QTL R I LT - KL E PYTEH h G MN LT RR TL LGVL KYP al Y S QVQ AP QLPPK vsnfrqlkasdwkppk GY YDCDQDVV dwvlapl 205
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 215 -- L D V A NYLGILPVDPASGHYV R HPLV -- YLV E A ADDI C Y Q V M D V EDA YK L RILSY E RTVDLLLRYFP A D G HDHVLATMQ 290
Cdd:NF041026 206 se N D R A LFTSLDEKPGKQHGKT R FKSL dc SIM E L ADDI A Y G V H D L EDA IV L GLVTR E QWQEAVAPKLA A L G DPWLSDNLD 285
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 291 SIG D R --- N E R ia Y L R AK AI NI LV EA caev FI EHE E EILHGT F AGT L VS qmperl Y E A YRANSAV A QS E I --- YTARA VI 364
Cdd:NF041026 286 ELS D K lfs G E H -- Y E R KD AI GA LV NY ---- FI TSI E IKEVDA F EEP L LR ------ Y N A VLPPEVA A LL E V lkq FVYQY VI 353
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 365 D ------ V E LA G HR I FS EL IDK L MH --- S LL h P DDAYS R tllslvssq YNLH EE SIYGKLQCTL DYI S GMTD P YAL D LY R 435
Cdd:NF041026 354 R spevqq L E YK G QQ I VM EL FEA L AS dpe R LL - P ENTRE R --------- WQEA EE DGENGKRVIC DYI A GMTD E YAL R LY Q 423
..
gi 490461253 436 R I 437
Cdd:NF041026 424 R L 425
PRK05318
PRK05318 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
1-437
6.85e-39
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 235403 [Multi-domain]
Cd Length: 432
Bit Score: 145.40
E-value: 6.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 1 MN W DQ lisn RR F G APEPE R A galgggm EM R TEFD RD YD R LIF SA P FRRLQ N K A Q IFPLPK N I F VHN RLTHSLEV SCV G RS 80
Cdd:PRK05318 4 SV W QE ---- RR L G EDKQR R N ------- DH R SPYQ RD RA R ILH SA A FRRLQ A K T Q VLGVGE N D F YRT RLTHSLEV AQI G TG 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 81 lgny I ARR L TDNQDTPHRGSIA -- TVVSAA CLAHD M G N PPFGH S GE R A IR a Y FTEGN G rqwydavv G eghpwedfay FEG 158
Cdd:PRK05318 73 ---- I VAQ L KKEKQPELKPLLP sd SLIESL CLAHD I G H PPFGH G GE V A LN - Y MMRDH G -------- G ---------- FEG 129
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 159 N ANG FR L LT h QF E GRRPG - G FA LT YT TL AA I V KYP -- W S SAR A PES ----------------- G K f G Y F QSERATYL --- 215
Cdd:PRK05318 130 N GQT FR I LT - KL E PYTEH f G MN LT RR TL LG I L KYP al Y S ELV A QYP ppdvanhrqlkasdwkp P K - G I F DDDQDIFD wvl 207
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 216 ------ D V A NYLGIL P V d P A S GHYVRHPL v Y ------ LV E A ADDI C Y Q V M D V EDA YK L RILS yertvdlllryf PADGHD 283
Cdd:PRK05318 208 eplsen D R A LFQSLR P E - P D S PKEHLKTR - Y ksldcs IM E L ADDI A Y G V H D L EDA IV L GLVT ------------ RSQWQE 273
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 284 H V LATMQSI GD RN -- E R I A ----------- Y LR AK AI NI LV EA caev FI EHEEEILHGT F AGT L VS qmperl Y E A YRANS 350
Cdd:PRK05318 274 D V APQLAQC GD PW le E E I E tigeklfsgeh H LR KD AI GT LV NY ---- FI TSIRIKENEE F EEP L LR ------ Y N A ALEPE 343
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 351 AV A QS E I --- YTARA VI D ------ V E LA G HR I FS EL IDK L M --- HS LL h P DDAYS R tllslvssq YNLH E ESI y GKLQCT 418
Cdd:PRK05318 344 FA A AL E V lkq FVYKY VI R kpevqr L E YK G QQ I VM EL FEA L S sdp ER LL - P RNTQE R --------- WRKA E DEE - NSMRVI 412
490
....*....|....*....
gi 490461253 419 L DYISGMTD P YA LD LY RRI 437
Cdd:PRK05318 413 C DYISGMTD E YA YR LY QQL 431
PRK03007
PRK03007 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
14-258
3.89e-37
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 235098 [Multi-domain]
Cd Length: 428
Bit Score: 140.47
E-value: 3.89e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 14 A PEP ERAGA L GGGMEM RT E F D RD YD R LIF SA PF RRL QN K A Q IFPLPKNIFVHN RLTHSLEV SCV GR S lgny IA RR L TDNQ 93
Cdd:PRK03007 18 V PEP PKSAG L PTEGQH RT D F A RD RA R VLH SA AL RRL AD K T Q VVGPREGDTPRT RLTHSLEV AQI GR G ---- IA AG L GCDP 93
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 94 D tphrgsiat V V SA A C LAHD M G N PP F GH S GERA I rayftegngrqwy D A V V geghpw E D FAY FEGNA NGF R L LT h QF E GR 173
Cdd:PRK03007 94 D --------- L V DL A G LAHD I G H PP Y GH N GERA L ------------- D E V A ------ A D CGG FEGNA QTL R I LT - RL E PK 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 174 ------ R PG G FA LT YTT L A A IV KYPW SSAR A PE S -- G KFG YFQSE R atyl D V ANYLGIL pvdp A SGH yv R HP L vylv EA - 244
Cdd:PRK03007 145 vldpdg R SA G LN LT RAS L D A AC KYPW TRGE A DG S pr R KFG FYDDD R ---- E V FAWVRQG ---- A PAG -- R PC L ---- EA q 210
250
....*....|....*...
gi 490461253 245 ---- ADD IC Y Q V M DVED A 258
Cdd:PRK03007 211 vmdw ADD VA Y S V H DVED G 228
PRK01286
PRK01286 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
10-441
1.50e-30
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
Pssm-ID: 234934 [Multi-domain]
Cd Length: 336
Bit Score: 120.27
E-value: 1.50e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 10 R RF ga PE PERA galgggme M RTEF D RD Y DR L I F S AP FRRL QN K A Q I F PL P KNIFVHN RLTH S LEV SCVG R S lgny IAR R L 89
Cdd:PRK01286 16 R LR -- PE EPCP -------- I RTEF Q RD R DR I I H S KA FRRL KH K T Q V F IN P EGDHYRT RLTH T LEV AQIA R T ---- IAR A L 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 90 TD N Q D tphrgsiat VVS A AC L A HD M G NP PFGH S GE R A IRAYFT E GN G rqwydavvgeghpwedfay FE G N ANGF R LLT h Q 169
Cdd:PRK01286 82 RL N E D --------- LTE A IA L G HD L G HT PFGH A GE D A LNELMK E YG G ------------------- FE H N EQSL R VVD - K 132
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 170 F E g R R PG G FA LT YTTLAA I V K Y pw S SA R APES G KFGYFQSE ratyld VANY lgilpvdpasghyvrhplvylvea AD D I C 249
Cdd:PRK01286 133 L E - K R YD G LN LT WEVREG I L K H -- S GP R NAPL G TAATLEGQ ------ IVRL ------------------------ AD E I A 179
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 250 Y QVM D VE D AYKLRILSY E rtv DL llryf P A D ghdh V LAT mqs I G DRNE R I aylraka IN I LV EAC aevf I EHEEEI L HGT 329
Cdd:PRK01286 180 Y NNH D ID D GIRAGLITL E --- DL ----- P E D ---- V RRL --- L G ETHR R R ------- IN T LV VDL ---- I KNTQRN L AEG 233
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490461253 330 F A GTLVSQMP E RLY EA ------------ YR ANSAVAQS E iytaravidvel AGH RI FSE L IDKL M H sll H P D daysrtll 397
Cdd:PRK01286 234 A A APPLVSFS E EVA EA mkelrrflfenv YR HPKVKRER E ------------ KAK RI VQD L FEYY M E --- D P E -------- 290
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 490461253 398 s L VSSQ Y NLHE E S i Y G KLQCTL DYI S GMTD P YAL DL YRR ITGMS 441
Cdd:PRK01286 291 - L LPPE Y QNIA E E - E G LERAVA DYI A GMTD R YAL RE YRR LFVPK 332
HD_assoc
pfam13286 Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
420-436
3.29e-04
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.
Pssm-ID: 433087 [Multi-domain]
Cd Length: 91
Bit Score: 39.43
E-value: 3.29e-04
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
