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Conserved domains on  [gi|488309772|ref|WP_002379157|]
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MULTISPECIES: D-alanine--D-alanine ligase [Enterococcus]

Protein Classification

D-alanine--D-alanine ligase family protein( domain architecture ID 11479728)

D-alanine--D-alanine ligase family protein similar to D-alanine--D-alanine ligase that catalyzes the synthesis of D-alanyl-D-alanine, an essential component of bacterial peptidoglycan, and is involved in cell wall formation

EC:  6.3.2.-
Gene Ontology:  GO:0009252|GO:0008716|GO:0046872|GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-345 2.15e-157

D-alanine--D-alanine ligase;


:

Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 444.56  E-value: 2.15e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   1 MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLSERpqnkevlhltWAQTPEETGEFSgKR 80
Cdd:PRK01966   4 MRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNME----------LADDDNDKEDLS-LL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ISPSEIYEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWKgn 160
Cdd:PRK01966  73 ILPSGGSEEVDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVVLTRGDWE-- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 161 pKEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNeDVRTTLPGE 240
Cdd:PRK01966 151 -EASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGN-DPKASVPGE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 241 VVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSM 320
Cdd:PRK01966 229 IVKPDDFYDYEAKYLDGSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMPGFTPISM 308

                        330       340
                 ....*....|....*....|....*
gi 488309772 321 YPLLWENMGLKYSDLIEELIQLALN 345
Cdd:PRK01966 309 YPKLWEASGLSYPELIDRLIELALE 333
 
Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-345 2.15e-157

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 444.56  E-value: 2.15e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   1 MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLSERpqnkevlhltWAQTPEETGEFSgKR 80
Cdd:PRK01966   4 MRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNME----------LADDDNDKEDLS-LL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ISPSEIYEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWKgn 160
Cdd:PRK01966  73 ILPSGGSEEVDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVVLTRGDWE-- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 161 pKEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNeDVRTTLPGE 240
Cdd:PRK01966 151 -EASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGN-DPKASVPGE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 241 VVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSM 320
Cdd:PRK01966 229 IVKPDDFYDYEAKYLDGSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMPGFTPISM 308

                        330       340
                 ....*....|....*....|....*
gi 488309772 321 YPLLWENMGLKYSDLIEELIQLALN 345
Cdd:PRK01966 309 YPKLWEASGLSYPELIDRLIELALE 333
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 1-344 1.15e-136

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 391.01  E-value: 1.15e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   1 MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFIskDGQWVKGPLLSERPqnkevlhltwaqtpeetgefsgkr 80
Cdd:COG1181    1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGI--DVEDLPAALKELKP------------------------ 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ispseiyeeeAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWkgn 160
Cdd:COG1181   55 ----------DVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGEL--- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 161 pkEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVRTTLPGE 240
Cdd:COG1181  122 --ADLEAIEEELGLPLFVKPAREGSSVGVSKVKNAEELAAALEEAFKYDDKVLVEEFIDGREVTVGVLGNGGPRALPPIE 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 241 VVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSM 320
Cdd:COG1181  200 IVPENGFYDYEAKYTDGGTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRLDEDGEPYLLEVNTLPGMTPTSL 279

                        330       340
                 ....*....|....*....|....
gi 488309772 321 YPLLWENMGLKYSDLIEELIQLAL 344
Cdd:COG1181  280 LPKAAAAAGISYEELIERIIELAL 303
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 2-343 7.53e-119

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 346.19  E-value: 7.53e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772    2 KIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLSERPQNKEVLhltwaqtpeetgefsgkri 81
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGSWTYKDLPQLILELGALL------------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   82 spseiyEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVpVLRSDWKGNP 161
Cdd:TIGR01205  62 ------EGIDVVFPVLHGRYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYI-VLTQNRASAD 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  162 KEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVrttLPG-- 239
Cdd:TIGR01205 135 ELECEQVAEPLGFPVIVKPAREGSSVGVSKVKSEEELQAALDEAFEYDEEVLVEQFIKGRELEVSILGNEEA---LPIie 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  240 EVVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFS 319
Cdd:TIGR01205 212 IVPEIEGFYDYEAKYLDGSTEYVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDEEGEIYLNEINTIPGMTAIS 291

                         330       340
                  ....*....|....*....|....
gi 488309772  320 MYPLLWENMGLKYSDLIEELIQLA 343
Cdd:TIGR01205 292 LFPKAAAAAGIEFSQLVERILELA 315
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 138-341 9.10e-108

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 313.87  E-value: 9.10e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  138 LLQTVGIPQVPFVPVLRSDWKGNPKEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQG 217
Cdd:pfam07478   1 LLKAAGLPVVPFVTFTRADWKLNPKEWCAQVEEALGYPVFVKPARLGSSVGVSKVESREELQAAIEEAFQYDEKVLVEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  218 IEAREIEVAILGNEDVRTTLPGEVVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFF 297
Cdd:pfam07478  81 IEGREIECAVLGNEDPEVSPVGEIVPSGGFYDYEAKYIDDSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFF 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 488309772  298 LTSKNELFLNELNTMPGFTDFSMYPLLWENMGLKYSDLIEELIQ 341
Cdd:pfam07478 161 LTEDGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLIE 204
 
Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-345 2.15e-157

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 444.56  E-value: 2.15e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   1 MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLSERpqnkevlhltWAQTPEETGEFSgKR 80
Cdd:PRK01966   4 MRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNME----------LADDDNDKEDLS-LL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ISPSEIYEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWKgn 160
Cdd:PRK01966  73 ILPSGGSEEVDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVVLTRGDWE-- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 161 pKEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNeDVRTTLPGE 240
Cdd:PRK01966 151 -EASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGN-DPKASVPGE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 241 VVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSM 320
Cdd:PRK01966 229 IVKPDDFYDYEAKYLDGSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMPGFTPISM 308

                        330       340
                 ....*....|....*....|....*
gi 488309772 321 YPLLWENMGLKYSDLIEELIQLALN 345
Cdd:PRK01966 309 YPKLWEASGLSYPELIDRLIELALE 333
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 1-344 1.15e-136

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 391.01  E-value: 1.15e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   1 MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFIskDGQWVKGPLLSERPqnkevlhltwaqtpeetgefsgkr 80
Cdd:COG1181    1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGI--DVEDLPAALKELKP------------------------ 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ispseiyeeeAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWkgn 160
Cdd:COG1181   55 ----------DVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGEL--- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 161 pkEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVRTTLPGE 240
Cdd:COG1181  122 --ADLEAIEEELGLPLFVKPAREGSSVGVSKVKNAEELAAALEEAFKYDDKVLVEEFIDGREVTVGVLGNGGPRALPPIE 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 241 VVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSM 320
Cdd:COG1181  200 IVPENGFYDYEAKYTDGGTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRLDEDGEPYLLEVNTLPGMTPTSL 279

                        330       340
                 ....*....|....*....|....
gi 488309772 321 YPLLWENMGLKYSDLIEELIQLAL 344
Cdd:COG1181  280 LPKAAAAAGISYEELIERIIELAL 303
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 2-343 7.53e-119

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 346.19  E-value: 7.53e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772    2 KIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLSERPQNKEVLhltwaqtpeetgefsgkri 81
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGSWTYKDLPQLILELGALL------------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   82 spseiyEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVpVLRSDWKGNP 161
Cdd:TIGR01205  62 ------EGIDVVFPVLHGRYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYI-VLTQNRASAD 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  162 KEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVrttLPG-- 239
Cdd:TIGR01205 135 ELECEQVAEPLGFPVIVKPAREGSSVGVSKVKSEEELQAALDEAFEYDEEVLVEQFIKGRELEVSILGNEEA---LPIie 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  240 EVVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFS 319
Cdd:TIGR01205 212 IVPEIEGFYDYEAKYLDGSTEYVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDEEGEIYLNEINTIPGMTAIS 291

                         330       340
                  ....*....|....*....|....
gi 488309772  320 MYPLLWENMGLKYSDLIEELIQLA 343
Cdd:TIGR01205 292 LFPKAAAAAGIEFSQLVERILELA 315
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 138-341 9.10e-108

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 313.87  E-value: 9.10e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  138 LLQTVGIPQVPFVPVLRSDWKGNPKEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQG 217
Cdd:pfam07478   1 LLKAAGLPVVPFVTFTRADWKLNPKEWCAQVEEALGYPVFVKPARLGSSVGVSKVESREELQAAIEEAFQYDEKVLVEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  218 IEAREIEVAILGNEDVRTTLPGEVVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFF 297
Cdd:pfam07478  81 IEGREIECAVLGNEDPEVSPVGEIVPSGGFYDYEAKYIDDSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFF 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 488309772  298 LTSKNELFLNELNTMPGFTDFSMYPLLWENMGLKYSDLIEELIQ 341
Cdd:pfam07478 161 LTEDGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLIE 204
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 1-346 1.41e-82

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 253.11  E-value: 1.41e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   1 MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDgqwvkgpllserpqnkeVLHLTWAQTPEetgefsgkr 80
Cdd:PRK01372   5 GKVAVLMGGTSAEREVSLNSGAAVLAALREAGYDAHPIDPGED-----------------IAAQLKELGFD--------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ispseiyeeeaIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVpVLRSDwkgn 160
Cdd:PRK01372  59 -----------RVFNALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAGLPTPPWI-VLTRE---- 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 161 pkEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVRTTlpgE 240
Cdd:PRK01372 123 --EDLLAAIDKLGLPLVVKPAREGSSVGVSKVKEEDELQAALELAFKYDDEVLVEKYIKGRELTVAVLGGKALPVI---E 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 241 VVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSM 320
Cdd:PRK01372 198 IVPAGEFYDYEAKYLAGGTQYICPAGLPAEIEAELQELALKAYRALGCRGWGRVDFMLDEDGKPYLLEVNTQPGMTSHSL 277

                        330       340
                 ....*....|....*....|....*.
gi 488309772 321 YPLLWENMGLKYSDLIEELIQLALNR 346
Cdd:PRK01372 278 VPMAARAAGISFSELVDRILEDALCD 303
PRK14570 PRK14570
D-alanyl-alanine synthetase A; Provisional
 3-352 2.18e-74

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173034 [Multi-domain]  Cd Length: 364  Bit Score: 234.34  E-value: 2.18e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   3 IILLYGGRSEEHDVSVLSAYSVLNAIY-YKYYQVQLVFISK-DGQWVkgpLLSERPQNKEVLHLtwaQTPEETGEFSGKR 80
Cdd:PRK14570   5 LMLIFGGVSFEHEISLRSAYGIYSALLkLDKYNIYSVFIDKcTGIWY---LLDSVPDPPKLIKR---DVLPIVSLIPGCG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ISPSEIYEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWKGN 160
Cdd:PRK14570  79 IFVNNKNLEIDVVFPIVHGRTGEDGAIQGFLKVMDIPCVGAGILGSAISINKYFCKLLLKSFNIPLVPFIGFRKYDYFLD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 161 PKEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVRTTLPGE 240
Cdd:PRK14570 159 KEGIKKDIKEVLGYPVIVKPAVLGSSIGINVAYNENQIEKCIEEAFKYDLTVVIEKFIEAREIECSVIGNEQIKIFTPGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 241 -VVKDVAFYDYDAKYI---NNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSK-NELFLNELNTMPGF 315
Cdd:PRK14570 239 iVVQDFIFYDYDAKYStipGNSIVFNIPAHLDTKHLLDIKEYAFLTYKNLELRGMARIDFLIEKDtGLIYLNEINTIPGF 318

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 488309772 316 TDFSMYPLLWENMGLKYSDLIEELIQLALNRFKQRQE 352
Cdd:PRK14570 319 TDISMFAKMCEHDGLQYKSLVDNLIDLAFQSYIKRKK 355
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
5-351 5.06e-67

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 225.47  E-value: 5.06e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   5 LLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLserpqnkevlhltwaqtPEETGEFSGKRISPS 84
Cdd:PRK14573 456 LVCGGKSCEHDISLLSAKNIAKYLSPEFYDVSYFLINRQGLWETVSSL-----------------ETAIEEDSGKSVLSS 518

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  85 EIYEEEA---IVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWKGNP 161
Cdd:PRK14573 519 EIAQALAkvdVVLPILHGPFGEDGTMQGFLEIIGKPYTGPSLAFSAIAMDKVLTKRFASDVGVPVVPYQPLTLAGWKREP 598

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 162 KEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQG-IEAREIEVAILGNEDVRTTL--P 238
Cdd:PRK14573 599 ELCLAHIVEAFSFPMFVKTAHLGSSIGVFEVHNVEELRDKISEAFLYDTDVFVEESrLGSREIEVSCLGDGSSAYVIagP 678

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 239 GEVVKDVAFYDYDAKYINNTI---EMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGF 315
Cdd:PRK14573 679 HERRGSGGFIDYQEKYGLSGKssaQIVFDLDLSKESQEQVLELAERIYRLLQGKGSCRIDFFLDEEGNFWLSEMNPIPGM 758

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 488309772 316 TDFSMYPLLWENMGLKYSDLIEELIQLALNRFKQRQ 351
Cdd:PRK14573 759 TEASPFLTAFVRKGWTYEQIVHQLIIDGLHKFDQRQ 794
PRK14572 PRK14572
D-alanyl-alanine synthetase A; Provisional
 2-344 1.32e-56

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173036 [Multi-domain]  Cd Length: 347  Bit Score: 187.81  E-value: 1.32e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   2 KIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKgPLLSERPQNKEVlhltwAQTPEETGEFSGKR- 80
Cdd:PRK14572   3 KIAVFFGGSSTEHSISIRTGCFICATLHTMGHSVKPILLTPDGGWVV-PTVYRPSIPDES-----GNSEDLFLEEFQKAn 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 -IS-PSEIYEEEA-IVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDW 157
Cdd:PRK14572  77 gVSePADISQLDAdIAFLGLHGGAGEDGRIQGFLDTLGIPYTGSGVLASALAMDKTRANQIFLQSGQKVAPFFELEKLKY 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 158 KGNPKEVFEKCEgSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAIL----GNEDV 233
Cdd:PRK14572 157 LNSPRKTLLKLE-SLGFPQFLKPVEGGSSVSTYKITNAEQLMTLLALIFESDSKVMSQSFLSGTEVSCGVLeryrGGKRN 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 234 RTTLPG-EVVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLtSKNELFLNELNTM 312
Cdd:PRK14572 236 PIALPAtEIVPGGEFFDFESKYKQGGSEEITPARISDQEMKRVQELAIRAHESLGCKGYSRTDFII-VDGEPHILETNTL 314

                        330       340       350
                 ....*....|....*....|....*....|..
gi 488309772 313 PGFTDFSMYPLLWENMGLKYSDLIEELIQLAL 344
Cdd:PRK14572 315 PGMTETSLIPQQAKAAGINMEEVFTDLIEIGL 346
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 2-121 1.67e-41

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 141.20  E-value: 1.67e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772    2 KIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWvkGPLLSERPQNKEVLHLTWAQTPEETGEFSGKRI 81
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDKEKYEVIPIGITKDGRL--GEAALRELASDDGLLLEVDDAPDGGPAGLLFGP 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 488309772   82 SPSEIYEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGA 121
Cdd:pfam01820  79 NVLELLIEVDVVFPVLHGPNGEDGTLQGLLELAGIPYVGS 118
PRK14571 PRK14571
D-alanyl-alanine synthetase A; Provisional
 1-343 4.24e-37

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 184751 [Multi-domain]  Cd Length: 299  Bit Score: 135.34  E-value: 4.24e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   1 MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDgqwvkgpLLSERPQNKEvlhltwaqtpeetgefsgkr 80
Cdd:PRK14571   1 MRVALLMGGVSREREISLRSGERVKKALEKLGYEVTVFDVDED-------FLKKVDQLKS-------------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ispseiYEeeaIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMT-KYLLQTVGIPQvpFVPVlrsdwkg 159
Cdd:PRK14571  54 ------FD---VVFNVLHGTFGEDGTLQAILDFLGIRYTGSDAFSSMICFDKLLTyRFLKGTVEIPD--FVEI------- 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 160 npKEVFEkcEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVRTTLPG 239
Cdd:PRK14571 116 --KEFMK--TSPLGYPCVVKPRREGSSIGVFICESDEEFQHALKEDLPRYGSVIVQEYIPGREMTVSILETEKGFEVLPI 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 240 -EVVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLtSKNELFLNELNTMPGFTDF 318
Cdd:PRK14571 192 lELRPKRRFYDYVAKYTKGETEFILPAPLNPEEERLVKETALKAFVEAGCRGFGRVDGIF-SDGRFYFLEINTVPGLTEL 270

                        330       340
                 ....*....|....*....|....*
gi 488309772 319 SMYPLLWENMGLKYSDLIEELIQLA 343
Cdd:PRK14571 271 SDLPASAKAGGIEFEELVDIIIKSA 295
PRK14569 PRK14569
D-alanyl-alanine synthetase A; Provisional
 2-343 9.99e-29

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173033 [Multi-domain]  Cd Length: 296  Bit Score: 112.85  E-value: 9.99e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772   2 KIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVqlVFISKDGQWVKGPLLSERPQNkevlhltwaqtpeetgefsgkri 81
Cdd:PRK14569   5 KIVVLYGGDSPEREVSLKSGKAVLDSLISQGYDA--VGVDASGKELVAKLLELKPDK----------------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  82 spseiyeeeaiVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPqVPFVPVLRSdwkgnp 161
Cdd:PRK14569  60 -----------CFVALHGEDGENGRVSALLEMLEIKHTSSSMKSSVITMDKMISKEILMHHRMP-TPMAKFLTD------ 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 162 kEVFEKCEGSliYPVFVKPANMGSSVGISKVENREELQEALEEAFRYdARAIVEQGIEAREIEVAILgNEDVRTTLPGEV 241
Cdd:PRK14569 122 -KLVAEDEIS--FPVAVKPSSGGSSIATFKVKSIQELKHAYEEASKY-GEVMIEQWVTGKEITVAIV-NDEVYSSVWIEP 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 242 VKDvaFYDYDAKYINNTIeMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSMY 321
Cdd:PRK14569 197 QNE--FYDYESKYSGKSI-YHSPSGLCEQKELEVRQLAKKAYDLLGCSGHARVDFIYDDRGNFYIMEINSSPGMTDNSLS 273

                        330       340
                 ....*....|....*....|..
gi 488309772 322 PLLWENMGLKYSDLIEELIQLA 343
Cdd:PRK14569 274 PKSAAAEGVDFDSFVKRIIEQA 295
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 120-346 2.66e-15

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 74.91  E-value: 2.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 120 GAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVlrsdwkGNPKEVFEKCEgSLIYPVFVKPANMGSSVGISKVENRE--- 196
Cdd:COG0439   43 GPSPEAIRAMRDKVLMREALAAAGVPVPGFALV------DSPEEALAFAE-EIGYPVVVKPADGAGSRGVRVVRDEEele 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 197 ---ELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEdvrttlpGEVVkdvaFYDYdAKYINNT---IEM--QIPAHVP 268
Cdd:COG0439  116 aalAEARAEAKAGSPNGEVLVEEFLEGREYSVEGLVRD-------GEVV----VCSI-TRKHQKPpyfVELghEAPSPLP 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 269 EEVAHQAQEYAKKAyimLDGSGLSRC----DFFLTSKNELFLNELNT-MPGftDFsMYPLLWENMGLkysDLIEELIQLA 343
Cdd:COG0439  184 EELRAEIGELVARA---LRALGYRRGafhtEFLLTPDGEPYLIEINArLGG--EH-IPPLTELATGV---DLVREQIRLA 254


                 ...
gi 488309772 344 LNR 346
Cdd:COG0439  255 LGE 257
PurK COG0026
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and ...
 131-309 1.64e-05

Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439797 [Multi-domain]  Cd Length: 353  Bit Score: 46.22  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 131 DKIMTKYLLQTVGIPQVPFVPVlrsdwkGNPKEVFEKCEgSLIYPVFVKPANMG----------SSVGISKVENREElqe 200
Cdd:COG0026   89 DRLLEKAFLAELGIPVAPFAAV------DSLEDLEAAIA-ELGLPAVLKTRRGGydgkgqvvikSAADLEAAWAALG--- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 201 aleeafryDARAIVEQGIE-AREIEVAILGNEDvrttlpGEVvkdvAFYDydakyinnTIEMQ----------IPAHVPE 269
Cdd:COG0026  159 --------GGPCILEEFVPfERELSVIVARSPD------GEV----ATYP--------VVENVhrngildesiAPARISE 212

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 488309772 270 EVAHQAQEYAKKayIM--LDGSGLSRCDFFLTSKNELFLNEL 309
Cdd:COG0026  213 ALAAEAEEIAKR--IAeaLDYVGVLAVEFFVTKDGELLVNEI 252
ATP-grasp pfam02222
ATP-grasp domain; This family does not contain all known ATP-grasp domain members. This family ...
 140-309 1.97e-05

ATP-grasp domain; This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 396689 [Multi-domain]  Cd Length: 169  Bit Score: 44.55  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  140 QTVGIPQVPFVPVlrsdwkgNPKEVFEKCEGSLIYPVFVKPANMGSS-VGISKVenREELQEALEEAFRYDARAIVEQGI 218
Cdd:pfam02222   1 QKLGLPTPRFMAA-------ESLEELIEAGQELGYPCVVKARRGGYDgKGQYVV--RSEADLPQAWEELGDGPVIVEEFV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  219 EArEIEVAILGNEDVRttlpGEVvkdvAFYD-YDAKYINNT-IEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDF 296
Cdd:pfam02222  72 PF-DRELSVLVVRSVD----GET----AFYPvVETIQEDGIcRLSVAPARVPQAIQAEAQDIAKRLVDELGGVGVFGVEL 142

                         170
                  ....*....|...
gi 488309772  297 FLTSKNELFLNEL 309
Cdd:pfam02222 143 FVTEDGDLLINEL 155
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 129-251 2.71e-05

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 45.26  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 129 AMDKIMTKYLLQTVGIPQVPFvpvlrsdWKGNPKEVFEKC--EGSLIYPVFVKPANMGSSVGISKVENReelqEALEEAF 206
Cdd:PRK12767 109 CNDKWLTYEFLKENGIPTPKS-------YLPESLEDFKAAlaKGELQFPLFVKPRDGSASIGVFKVNDK----EELEFLL 177

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488309772 207 RYDARAIVEQGIEAREIEVAIL--GNEDVRTTLP--------GEVVKDVAFYDYD 251
Cdd:PRK12767 178 EYVPNLIIQEFIEGQEYTVDVLcdLNGEVISIVPrkrievraGETSKGVTVKDPE 232
PLN02948 PLN02948
phosphoribosylaminoimidazole carboxylase
 264-308 4.89e-05

phosphoribosylaminoimidazole carboxylase


Pssm-ID: 178534 [Multi-domain]  Cd Length: 577  Bit Score: 45.05  E-value: 4.89e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 488309772 264 PAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNE 308
Cdd:PLN02948 241 PANVPWKVAKLATDVAEKAVGSLEGAGVFGVELFLLKDGQILLNE 285
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 125-315 3.73e-04

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 41.85  E-value: 3.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 125 ASANAMDKIMTKYLLQTVGIPqVPFVPVLRSdwKGNPKEVFEKcegsLIYPVFVKPANMGSSVGISKVENREELQEALEE 204
Cdd:COG0189   90 AIRRARDKLFTLQLLARAGIP-VPPTLVTRD--PDDLRAFLEE----LGGPVVLKPLDGSGGRGVFLVEDEDALESILEA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 205 AFRYDARAIVEQ----GIEAREIEVAILGnedvrttlpGEVVkdvAFYDYDAK----YINNTIEMQI-PAHVPEEVAHQA 275
Cdd:COG0189  163 LTELGSEPVLVQefipEEDGRDIRVLVVG---------GEPV---AAIRRIPAegefRTNLARGGRAePVELTDEERELA 230

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 488309772 276 QEYAKKAyimldGSGLSRCDFFLTsKNELFLNELNTMPGF 315
Cdd:COG0189  231 LRAAPAL-----GLDFAGVDLIED-DDGPLVLEVNVTPGF 264
PRK08462 PRK08462
acetyl-CoA carboxylase biotin carboxylase subunit;
81-311 1.86e-03

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236269 [Multi-domain]  Cd Length: 445  Bit Score: 40.11  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772  81 ISPSEIYEEEAIvFPVlHGPNGEDgtiQGFMETI---NMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPfvpvlRSDW 157
Cdd:PRK08462  69 ISAAEIFEADAI-FPG-YGFLSEN---QNFVEICshhNIKFIGPSVEVMALMSDKSKAKEVMKRAGVPVIP-----GSDG 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 158 KGNPKEVFEKCEGSLIYPVFVKPANMGSSVGI------SKVENREELQEALEEAFRYDARAIVEQGIE-AREIEVAILGN 230
Cdd:PRK08462 139 ALKSYEEAKKIAKEIGYPVILKAAAGGGGRGMrvvedeSDLENLYLAAESEALSAFGDGTMYMEKFINnPRHIEVQILGD 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488309772 231 EDVRTTLPGEvvKDVAFYDYDAKYINNTiemqiPAHV-PEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNEL 309
Cdd:PRK08462 219 KHGNVIHVGE--RDCSLQRRHQKLIEES-----PAVVlDEKTRERLHETAIKAAKAIGYEGAGTFEFLLDSNLDFYFMEM 291


                 ..
gi 488309772 310 NT 311
Cdd:PRK08462 292 NT 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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