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Conserved domains on  [gi|446292654|ref|WP_000370509|]
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MULTISPECIES: cation:proton antiporter [Gammaproteobacteria]

Protein Classification

cation:proton antiporter( domain architecture ID 10014017)

cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12599 PRK12599
putative monovalent cation/H+ antiporter subunit F; Reviewed
 5-92 8.28e-21

putative monovalent cation/H+ antiporter subunit F; Reviewed


:

Pssm-ID: 237148  Cd Length: 91  Bit Score: 78.41  E-value: 8.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446292654  5 LPLAIHFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARF 84
Cdd:PRK12599  4 LEDAFLIAAVLLVLALILSLYRVILGPTLPDRVVALDTLNTITVGIIAVLAAATGRPLYLDIAIVYALLSFLGTVAIAKY 83


                ....*...
gi 446292654 85 IAKRKGEL 92
Cdd:PRK12599 84 LVGRGGVL 91
 
Name Accession Description Interval E-value
PRK12599 PRK12599
putative monovalent cation/H+ antiporter subunit F; Reviewed
 5-92 8.28e-21

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 237148  Cd Length: 91  Bit Score: 78.41  E-value: 8.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446292654  5 LPLAIHFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARF 84
Cdd:PRK12599  4 LEDAFLIAAVLLVLALILSLYRVILGPTLPDRVVALDTLNTITVGIIAVLAAATGRPLYLDIAIVYALLSFLGTVAIAKY 83


                ....*...
gi 446292654 85 IAKRKGEL 92
Cdd:PRK12599 84 LVGRGGVL 91
MnhF COG2212
Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];
5-87 3.27e-17

Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441814  Cd Length: 84  Bit Score: 69.36  E-value: 3.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446292654  5 LPLAIHFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARF 84
Cdd:COG2212   2 MTTVLLIALALLALALLLALYRLIRGPTLADRVLALDTLGTNAVALLALLGILTGRPLYLDVALVLALLGFVGTVAFARF 81


                ...
gi 446292654 85 IAK 87
Cdd:COG2212  82 LER 84
MrpF_PhaF pfam04066
Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF ...
 35-85 9.94e-10

Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation. It is also involved in symbiosis in Rhizobium meliloti. MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis. MrpF is thought to be an efflux system for Na+ and cholate. The Mrp system in Bacilli may also have primary energization capacities.


Pssm-ID: 461156  Cd Length: 52  Bit Score: 49.32  E-value: 9.94e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446292654  35 DRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARFI 85
Cdd:pfam04066  1 DRVVALDTLGTNIVALLALLAILTGRPAYLDVALVLALLGFVGTVAFARFL 51
 
Name Accession Description Interval E-value
PRK12599 PRK12599
putative monovalent cation/H+ antiporter subunit F; Reviewed
 5-92 8.28e-21

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 237148  Cd Length: 91  Bit Score: 78.41  E-value: 8.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446292654  5 LPLAIHFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARF 84
Cdd:PRK12599  4 LEDAFLIAAVLLVLALILSLYRVILGPTLPDRVVALDTLNTITVGIIAVLAAATGRPLYLDIAIVYALLSFLGTVAIAKY 83


                ....*...
gi 446292654 85 IAKRKGEL 92
Cdd:PRK12599 84 LVGRGGVL 91
MnhF COG2212
Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];
5-87 3.27e-17

Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441814  Cd Length: 84  Bit Score: 69.36  E-value: 3.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446292654  5 LPLAIHFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARF 84
Cdd:COG2212   2 MTTVLLIALALLALALLLALYRLIRGPTLADRVLALDTLGTNAVALLALLGILTGRPLYLDVALVLALLGFVGTVAFARF 81


                ...
gi 446292654 85 IAK 87
Cdd:COG2212  82 LER 84
PRK12600 PRK12600
Na(+)/H(+) antiporter subunit F1;
7-87 5.63e-13

Na(+)/H(+) antiporter subunit F1;


Pssm-ID: 183617  Cd Length: 94  Bit Score: 58.79  E-value: 5.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446292654  7 LAIHFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARFIA 86
Cdd:PRK12600  4 IILSIALIIVAISMLLMLIRVIKGPTLADRVVALDAIGINLIAIIALFSILLDTKAYLEVILLIGILAFIGTAAFSKFIE 83


                .
gi 446292654 87 K 87
Cdd:PRK12600 84 K 84
PRK06161 PRK06161
putative monovalent cation/H+ antiporter subunit F; Reviewed
 5-85 1.14e-11

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 180435  Cd Length: 89  Bit Score: 55.24  E-value: 1.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446292654  5 LPLAIHFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARF 84
Cdd:PRK06161  2 LAWAILIAQVALALAMLLALWRLLRGPRAQDRILALDTLYINAILLLLVFGIRLGSTIYFEAALLIALLGFVSTVALAKF 81


                .
gi 446292654 85 I 85
Cdd:PRK06161 82 L 82
MrpF_PhaF pfam04066
Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF ...
 35-85 9.94e-10

Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation. It is also involved in symbiosis in Rhizobium meliloti. MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis. MrpF is thought to be an efflux system for Na+ and cholate. The Mrp system in Bacilli may also have primary energization capacities.


Pssm-ID: 461156  Cd Length: 52  Bit Score: 49.32  E-value: 9.94e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446292654  35 DRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARFI 85
Cdd:pfam04066  1 DRVVALDTLGTNIVALLALLAILTGRPAYLDVALVLALLGFVGTVAFARFL 51
PRK12604 PRK12604
putative monovalent cation/H+ antiporter subunit F; Reviewed
 22-85 5.91e-07

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 183619  Cd Length: 84  Bit Score: 43.21  E-value: 5.91e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446292654 22 MAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARFI 85
Cdd:PRK12604 17 LSMYRVFRGPTTVDRLVAVDIMTTITTGLMVLFALYYKRMIFLDVALVYAILAFVGVIAFARYL 80
PRK12657 PRK12657
putative monovalent cation/H+ antiporter subunit F; Reviewed
 9-85 1.98e-06

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 183657  Cd Length: 100  Bit Score: 42.06  E-value: 1.98e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446292654   9 IHFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARFI 85
Cdd:PRK12657  10 IISALIIFGIALIICLFRLIKGPTTADRVVTFDTTSAVVMSIVGVLSVLMGTVSFLDSIMLIAIISFVSSVSISRFI 86
PRK07948 PRK07948
putative monovalent cation/H+ antiporter subunit F; Reviewed
 10-84 2.44e-05

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 181179  Cd Length: 86  Bit Score: 38.90  E-value: 2.44e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446292654 10 HFAYLGLLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARF 84
Cdd:PRK07948  6 TIAAVFLSLAAILTTYRILAGPNSLDRLVALDTLVAVTMCALATWAAWTLDTTVTNAMTALALIGFIGSVSVARF 80
PRK08381 PRK08381
putative monovalent cation/H+ antiporter subunit F; Reviewed
 16-89 1.66e-04

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 169414  Cd Length: 87  Bit Score: 37.03  E-value: 1.66e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446292654 16 LLLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARFIAKRK 89
Cdd:PRK08381 14 LLFTALLASYRVIFGPTLADRIVGLNTITTKVVGIIAILSVLWEEYYLLDLAIVLLMVNAVGGLILAKYMERRG 87
PRK12612 PRK12612
putative monovalent cation/H+ antiporter subunit F; Reviewed
 17-87 4.18e-03

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 237151  Cd Length: 87  Bit Score: 32.98  E-value: 4.18e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446292654 17 LLSLAMAFIRLVLGPSLADRVVALDLISFITIGFIVVYSLDSGQQTLLDIALTLGLVAFLGTIAFARFIAK 87
Cdd:PRK12612 14 LLVILLALVLIIRTKDILTRLVISDMVFYAMALILLCLGLYNGTSIYYDIALAAGLLGFLGTIAYARIISG 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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