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Conserved domains on  [gi|27436881|ref|NP_003231|]
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left-right determination factor 2 isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGF_beta_LEFTY1_2 cd13758
transforming growth factor beta (TGF-beta) like domain found in left-right determination ...
 262-353 9.47e-47

transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins; Lefty-1, also termed left-right determination factor B, or protein lefty-B, is required for left-right axis determination as a regulator of Lefty-2 and NODAL. Lefty-2, also termed endometrial bleeding-associated factor, or left-right determination factor A, or protein lefty-A, or transforming growth factor beta-4 (TGF-beta-4), is required for left-right (L-R) asymmetry determination of organ systems in mammals. It may play a role in endometrial bleeding.


:

Pssm-ID: 381636  Cd Length: 90  Bit Score: 154.06  E-value: 9.47e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 262 RCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAfnWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVV 341
Cdd:cd13758   1 TCCRQEYYIDFRELTWTDYWIIEPPGYQAYECVGGCPQPPPPLA--WPSLGHRQCGVSESASLPMMYLVKKGDYTEVEVA 78

                        90
                ....*....|..
gi 27436881 342 SLPNMRVQKCSC 353
Cdd:cd13758  79 EFPNMIVEKCGC 90
TGFb_propeptide super family cl46657
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 106-203 4.98e-08

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


The actual alignment was detected with superfamily member pfam00688:

Pssm-ID: 480997  Cd Length: 239  Bit Score: 53.09  E-value: 4.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881   106 RLPPNSELVQAVLRLFQEPVPKAALHRhgrlsprsaQARVTV-EWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAV 184
Cdd:pfam00688 119 EIPEGELVTSAELRLYKDKVKARTSNE---------TFRIEVyQVLKEHDGGDASLRLLDSRLVTASEEGWLSFDVTEAL 189

                          90
                  ....*....|....*....
gi 27436881   185 NFWqqLSRPRQPLLLQVSV 203
Cdd:pfam00688 190 NRW--LANPEENLGLQLSV 206
 
Name Accession Description Interval E-value
TGF_beta_LEFTY1_2 cd13758
transforming growth factor beta (TGF-beta) like domain found in left-right determination ...
 262-353 9.47e-47

transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins; Lefty-1, also termed left-right determination factor B, or protein lefty-B, is required for left-right axis determination as a regulator of Lefty-2 and NODAL. Lefty-2, also termed endometrial bleeding-associated factor, or left-right determination factor A, or protein lefty-A, or transforming growth factor beta-4 (TGF-beta-4), is required for left-right (L-R) asymmetry determination of organ systems in mammals. It may play a role in endometrial bleeding.


Pssm-ID: 381636  Cd Length: 90  Bit Score: 154.06  E-value: 9.47e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 262 RCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAfnWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVV 341
Cdd:cd13758   1 TCCRQEYYIDFRELTWTDYWIIEPPGYQAYECVGGCPQPPPPLA--WPSLGHRQCGVSESASLPMMYLVKKGDYTEVEVA 78

                        90
                ....*....|..
gi 27436881 342 SLPNMRVQKCSC 353
Cdd:cd13758  79 EFPNMIVEKCGC 90
TGF_beta pfam00019
Transforming growth factor beta like domain;
262-353 4.38e-13

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 64.65  E-value: 4.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881   262 RCCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCQQPPEALAFN-------------WPFLGPRQ-CIASETASLPMI 327
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWD-DWIIAPKGYNAYYCSGSCPSHLNPQLSAtnhailqsllhslKPANVPKPcCVPTKLSPLSVL 79

                          90       100
                  ....*....|....*....|....*.
gi 27436881   328 VSIKEGgrtRPQVVSLPNMRVQKCSC 353
Cdd:pfam00019  80 YYDDEG---NVVLKTYPDMVVESCGC 102
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 263-353 7.17e-10

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 55.74  E-value: 7.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881    263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQPPeALAFNWPF----------LGPRQ-----CIASETASLPMI 327
Cdd:smart00204   1 CRRRQLYVDFKDLGW-DDWIIAPKGYNAYYCEGECPFPL-STSLNATNhaivqtlvhlLGPNPvpkpcCVPTKLSPLSML 78

                           90       100
                   ....*....|....*....|....*....
gi 27436881    328 vSIKEGGRtrpqvVSL---PNMRVQKCSC 353
Cdd:smart00204  79 -YYDDDGN-----VVLrnyPNMVVEECGC 101
TGFb_propeptide pfam00688
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 106-203 4.98e-08

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


Pssm-ID: 459906  Cd Length: 239  Bit Score: 53.09  E-value: 4.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881   106 RLPPNSELVQAVLRLFQEPVPKAALHRhgrlsprsaQARVTV-EWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAV 184
Cdd:pfam00688 119 EIPEGELVTSAELRLYKDKVKARTSNE---------TFRIEVyQVLKEHDGGDASLRLLDSRLVTASEEGWLSFDVTEAL 189

                          90
                  ....*....|....*....
gi 27436881   185 NFWqqLSRPRQPLLLQVSV 203
Cdd:pfam00688 190 NRW--LANPEENLGLQLSV 206
PHA02913 PHA02913
TGF-beta-like protein; Provisional
 263-353 2.07e-04

TGF-beta-like protein; Provisional


Pssm-ID: 177497  Cd Length: 172  Bit Score: 41.54  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881  263 CCRQEMYIDLQG-MKWakNWVLEPPGFLAYECVGTCQQP-------PEALAF--NWPFLGPRQCIASETASlPMIVSIKE 332
Cdd:PHA02913  77 CCIRDFNIDFKAdMGM--KWILKPEGTHANLCIGICSISnhkkinlMYGTAFkhHMPDNTIPFCCAPIKMK-NFIIAYKE 153

                         90       100
                 ....*....|....*....|.
gi 27436881  333 GGRTRPQVVSlpNMRVQKCSC 353
Cdd:PHA02913 154 GRKIKTDNIK--NFKILECAC 172
 
Name Accession Description Interval E-value
TGF_beta_LEFTY1_2 cd13758
transforming growth factor beta (TGF-beta) like domain found in left-right determination ...
 262-353 9.47e-47

transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins; Lefty-1, also termed left-right determination factor B, or protein lefty-B, is required for left-right axis determination as a regulator of Lefty-2 and NODAL. Lefty-2, also termed endometrial bleeding-associated factor, or left-right determination factor A, or protein lefty-A, or transforming growth factor beta-4 (TGF-beta-4), is required for left-right (L-R) asymmetry determination of organ systems in mammals. It may play a role in endometrial bleeding.


Pssm-ID: 381636  Cd Length: 90  Bit Score: 154.06  E-value: 9.47e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 262 RCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAfnWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVV 341
Cdd:cd13758   1 TCCRQEYYIDFRELTWTDYWIIEPPGYQAYECVGGCPQPPPPLA--WPSLGHRQCGVSESASLPMMYLVKKGDYTEVEVA 78

                        90
                ....*....|..
gi 27436881 342 SLPNMRVQKCSC 353
Cdd:cd13758  79 EFPNMIVEKCGC 90
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 263-353 1.79e-15

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 71.36  E-value: 1.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCQQPPEA-------------LAFNWPFLGPRQCIASETASLPMIVS 329
Cdd:cd08698   1 CCKQPLYVNFKDLGGL-NWIIAPSGFTANYCRGSCNSESSAttnhtkllqwsrtRRHTPREELKPCCVPTSYEPLSILYY 79

                        90       100
                ....*....|....*....|....
gi 27436881 330 IKEGGRTRpqvVSLPNMRVQKCSC 353
Cdd:cd08698  80 DNNGTVVE---TLLPNLIVTECGC 100
TGF_beta_INHB cd13752
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ...
 263-353 3.62e-13

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381630  Cd Length: 100  Bit Score: 64.98  E-value: 3.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQPP------------EALAFNWPFLGPRQCIA-SETASLPMIVS 329
Cdd:cd13752   1 CCRESFYVSFTDIGW-DDWIIAPSGYYANYCKGSCSGSSspfrshhttilqKYLSKNKAKSELTPCCTpTKMSPLSLLYY 79

                        90       100
                ....*....|....*....|....
gi 27436881 330 IKEgGRTRPQVvsLPNMRVQKCSC 353
Cdd:cd13752  80 DSD-GNIVKKD--LPNMIVESCGC 100
TGF_beta pfam00019
Transforming growth factor beta like domain;
262-353 4.38e-13

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 64.65  E-value: 4.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881   262 RCCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCQQPPEALAFN-------------WPFLGPRQ-CIASETASLPMI 327
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWD-DWIIAPKGYNAYYCSGSCPSHLNPQLSAtnhailqsllhslKPANVPKPcCVPTKLSPLSVL 79

                          90       100
                  ....*....|....*....|....*.
gi 27436881   328 VSIKEGgrtRPQVVSLPNMRVQKCSC 353
Cdd:pfam00019  80 YYDDEG---NVVLKTYPDMVVESCGC 102
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 263-353 2.26e-12

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 62.72  E-value: 2.26e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCQQPPEA-------------LAFNWPFLGPRQ--CIASETASLPMI 327
Cdd:cd13756   1 CRRRPLYVDFSDLGWD-DWIIAPKGYNANYCAGSCPFPLSShanatnhailqalLHSLNPKKSVPKpcCVPTKYSPLSVL 79

                        90       100
                ....*....|....*....|....*.
gi 27436881 328 VSIKEGGrtrPQVVSLPNMRVQKCSC 353
Cdd:cd13756  80 YYDEDGN---VVLKTYPDMVVEECGC 102
TGF_beta_GDF8_like cd13751
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, ...
 261-353 2.55e-10

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins; The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381629  Cd Length: 96  Bit Score: 56.90  E-value: 2.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 261 TRCCRQEMYIDLQGMKWakNWVLEPPGFLAYECVGTC-----QQPPEALAFN--WPFLGPRQ-CIASETASLPMIVSIKE 332
Cdd:cd13751   1 TRCCRYPLTVDFEEFGW--DWIIAPKTYDANYCSGECpfvylQSYPHTHLVQqaNPRGSAGPcCTPTKMSPLSMLYFDED 78

                        90       100
                ....*....|....*....|.
gi 27436881 333 GGRtrpQVVSLPNMRVQKCSC 353
Cdd:cd13751  79 GNI---IYGTLPDMVVERCGC 96
TGF_beta_INHA_B_like cd19377
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), ...
 263-353 5.07e-10

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381647  Cd Length: 101  Bit Score: 55.94  E-value: 5.07e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQ--------------CIASETASLPMIv 328
Cdd:cd19377   1 CCRVALFVSFEELGW-NRWIIAPPGFNFHFCHGGCALHIVPDLSLPVPSAPPTparpysvlpgaqpcCAPTKVTPLSVL- 78

                        90       100
                ....*....|....*....|....*
gi 27436881 329 SIKEGGRTRPQvvSLPNMRVQKCSC 353
Cdd:cd19377  79 YTSDGGTIKYE--TIPDLIVQECGC 101
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 263-353 7.17e-10

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 55.74  E-value: 7.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881    263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQPPeALAFNWPF----------LGPRQ-----CIASETASLPMI 327
Cdd:smart00204   1 CRRRQLYVDFKDLGW-DDWIIAPKGYNAYYCEGECPFPL-STSLNATNhaivqtlvhlLGPNPvpkpcCVPTKLSPLSML 78

                           90       100
                   ....*....|....*....|....*....
gi 27436881    328 vSIKEGGRtrpqvVSL---PNMRVQKCSC 353
Cdd:smart00204  79 -YYDDDGN-----VVLrnyPNMVVEECGC 101
TGFb_propeptide pfam00688
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 106-203 4.98e-08

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


Pssm-ID: 459906  Cd Length: 239  Bit Score: 53.09  E-value: 4.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881   106 RLPPNSELVQAVLRLFQEPVPKAALHRhgrlsprsaQARVTV-EWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAV 184
Cdd:pfam00688 119 EIPEGELVTSAELRLYKDKVKARTSNE---------TFRIEVyQVLKEHDGGDASLRLLDSRLVTASEEGWLSFDVTEAL 189

                          90
                  ....*....|....*....
gi 27436881   185 NFWqqLSRPRQPLLLQVSV 203
Cdd:pfam00688 190 NRW--LANPEENLGLQLSV 206
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 263-353 6.88e-08

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 50.00  E-value: 6.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQG-MKWakNWVLEPPGFLAYECVGTCqqppealAFNWPF-------------LGPRQ-----CIASETAS 323
Cdd:cd13753   1 CCLRPLYINFRRdLGW--KWIHEPKGFNANYCAGAC-------PYLWSAdtqhstvlqlynrLNPVAsaapcCSPRELEP 71

                        90       100       110
                ....*....|....*....|....*....|
gi 27436881 324 LPMIVSIKEGgrtrPQVVSLPNMRVQKCSC 353
Cdd:cd13753  72 LTILYYDGRN----PKIETLSNMIVTSCKC 97
TGF_beta_maverick cd13755
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 260-353 1.06e-07

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.


Pssm-ID: 381633  Cd Length: 102  Bit Score: 49.62  E-value: 1.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 260 GTRCCRQEMYIDL-QGMKWakNWVLEPPGFLAYECVGTCqqPPE-------ALAFNWPFLG----PRQCIA-SETASLpM 326
Cdd:cd13755   1 TKKCCRHSLKVDFkKLPGF--EWIIQPKEFDAGYCKGRC--PPRynyannhALIQSLLRRMkkkvPRPCCApSKLESL-E 75

                        90       100
                ....*....|....*....|....*..
gi 27436881 327 IVSIKEGGRTRPQVVSLPNMRVQKCSC 353
Cdd:cd13755  76 VLHYDESDSSKLKVTKWKGMIVSECAC 102
TGF_beta_GDF15 cd19376
transforming growth factor beta (TGF-beta) like domain found in mammalian growth ...
 261-354 1.57e-07

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.


Pssm-ID: 381646  Cd Length: 101  Bit Score: 48.85  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 261 TRCCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCqqPPEALA-------------FNWPFLGPRQCIASETAslPMI 327
Cdd:cd19376   1 GRCCRFSLRVSFKEIGWA-DWVLAPESYNAYYCDGSC--PHNYKPanmhaqiksrlhrLNPGAVPAPCCVPSSYE--PLT 75

                        90       100
                ....*....|....*....|....*..
gi 27436881 328 VsIKEGGRTRPQVVSLPNMRVQKCSCA 354
Cdd:cd19376  76 L-LHYDSDGKLTLTEFDDMIVKDCHCA 101
TGF_beta_INHBB cd19405
transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) ...
 263-354 1.69e-07

transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins; INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381675  Cd Length: 107  Bit Score: 49.16  E-value: 1.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQ-----PPEALAFNWPFLGPRQ------------CIASETASLP 325
Cdd:cd19405   3 CCRQQFYIDFRLIGW-NDWIIAPVGYYGNYCEGSCPAymagvPGSASSFHTAVVNQYRmrgmnpgtvnscCIPTKLSTMS 81

                        90       100
                ....*....|....*....|....*....
gi 27436881 326 MIVSIKEGGRTRPQVvslPNMRVQKCSCA 354
Cdd:cd19405  82 MLYFDDEYNIVKRDV---PNMIVEECGCA 107
TGF_beta_DAF7 cd19378
transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer ...
 263-353 3.38e-07

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.


Pssm-ID: 381648  Cd Length: 100  Bit Score: 48.10  E-value: 3.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQGMKWakNWVLEPPGFLAYECVGTC------QQPPEALAFNWPFLGPRQ------CIASETASLPMIVsI 330
Cdd:cd19378   3 CCLYDLTIDFEEIGW--NFIIAPKKYNANMCRGDCksnhhhRPNSASILLNPITRSESKqehgscCHPTEYDPITVVY-F 79

                        90       100
                ....*....|....*....|...
gi 27436881 331 KEGGRTRpqVVSLPNMRVQKCSC 353
Cdd:cd19378  80 NEDGQLK--IKTINGMIAKKCSC 100
TGF_beta_ADMP cd13765
transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic ...
 263-300 9.97e-07

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).


Pssm-ID: 381643  Cd Length: 105  Bit Score: 46.97  E-value: 9.97e-07
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd13765   3 CQRHELYVDFEEIGWS-GWIISPKGYNAYHCKGSCPFP 39
TGF_beta_BMP3 cd19393
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 259-353 2.15e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.


Pssm-ID: 381663  Cd Length: 110  Bit Score: 46.18  E-value: 2.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 259 EGTRCCRQEMYIDLQGMKWAKnWVLEPPGFLAYECVGTCQQP-PEALAFN--------------WPFLgPRQCIASETAS 323
Cdd:cd19393   4 EPRNCARRYLKVDFADIGWSE-WIISPKSFDAYYCSGACQFPmPKSLKPSnhatiqsivravgvVPGI-PEPCCVPEKMS 81

                        90       100       110
                ....*....|....*....|....*....|
gi 27436881 324 LPMIVSIKEGGRTrpQVVSLPNMRVQKCSC 353
Cdd:cd19393  82 SLSILFFDENKNV--VLKVYPNMTVESCAC 109
TGF_beta_TGFB3 cd19386
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 263-354 4.63e-06

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381656  Cd Length: 101  Bit Score: 45.01  E-value: 4.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDL-QGMKWakNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVS--------IKEG 333
Cdd:cd19386   4 CCVRPLYIDFrQDLGW--KWVHEPKGYFANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPqdlepltiLYYV 81

                        90       100
                ....*....|....*....|.
gi 27436881 334 GRTrPQVVSLPNMRVQKCSCA 354
Cdd:cd19386  82 GRT-PKVEQLSNMVVKSCKCS 101
TGF_beta_BMP9_like cd13767
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, ...
 263-300 4.85e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, BMP-9, BMP-10 and similar proteins; The family includes BMP9 (also known as GDF2) and BMP10. BMP-9 is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381645  Cd Length: 105  Bit Score: 44.66  E-value: 4.85e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWAKnWVLEPPGFLAYECVGTCQQP 300
Cdd:cd13767   3 CRRKPLYVNFADIGWDS-WIIAPKGYEAYECSGKCFFP 39
TGF_beta_univin cd19387
transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus ...
 263-300 1.40e-05

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.


Pssm-ID: 381657  Cd Length: 104  Bit Score: 43.64  E-value: 1.40e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19387   3 CQRHSLYVDFKDVGWS-DWIIAPRGYQAYRCAGECPFP 39
TGF_beta_BMP10 cd19401
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 ...
 263-300 1.60e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381671  Cd Length: 105  Bit Score: 43.31  E-value: 1.60e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19401   3 CKRSPLYVDFKEIGW-DSWIIAPTGYEAYECRGVCYYP 39
TGF_beta_TGFB2 cd19385
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 263-353 2.01e-05

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins; TGF-beta-2, also termed BSC-1 cell growth inhibitor, or cetermin, or glioblastoma-derived T-cell suppressor factor (G-TSF), or polyergin, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth.


Pssm-ID: 381655  Cd Length: 97  Bit Score: 43.10  E-value: 2.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQ-GMKWakNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVS--------IKEG 333
Cdd:cd19385   1 CCLRPLYIDFKrDLGW--KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSqdlepltiLYYI 78

                        90       100
                ....*....|....*....|
gi 27436881 334 GRTrPQVVSLPNMRVQKCSC 353
Cdd:cd19385  79 GKT-PKIEQLSNMIVKSCKC 97
TGF_beta_BMP5_like cd13761
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins ...
 262-300 2.48e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins; The family includes BMP-5, BMP-6, BMP-7 and BMP-8A/B, which may induce cartilage and bone formation.


Pssm-ID: 381639  Cd Length: 103  Bit Score: 42.56  E-value: 2.48e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 27436881 262 RCCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd13761   1 SCRRHNLYVDFRDLGW-QDWIIAPDGYNAYYCSGECSFP 38
TGF_beta_BMP8 cd19398
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A ...
 263-300 2.77e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.


Pssm-ID: 381668  Cd Length: 105  Bit Score: 42.60  E-value: 2.77e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19398   4 CKRHELYVSFQDLGW-LDWVIAPQGYSAYYCEGECSFP 40
TGF_beta_GDF8 cd19388
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 250-354 4.22e-05

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.


Pssm-ID: 381658  Cd Length: 108  Bit Score: 42.33  E-value: 4.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 250 DCDPEApmTEgTRCCRQEMYIDLQGMKWakNWVLEPPGFLAYECVGTC-----QQPPEALAFNWPflGPRQ-----CIAS 319
Cdd:cd19388   4 DCDEHS--TE-SRCCRYPLTVDFEAFGW--DWIIAPKRYKANYCSGECefvflQKYPHTHLVHQA--NPRGsagpcCTPT 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 27436881 320 ETASLPMIVSikeggRTRPQVV--SLPNMRVQKCSCA 354
Cdd:cd19388  77 KMSPINMLYF-----NGKEQIIygKIPAMVVDRCGCS 108
TGF_beta_BMP3_like cd13763
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 263-353 6.50e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381641  Cd Length: 103  Bit Score: 41.58  E-value: 6.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCQQP-PEALAFN--------------WPFLGPRQCIASETASLpMI 327
Cdd:cd13763   1 CSRRPLTVDFADIGWS-DWIISPKSFDAYYCAGSCPFPlTKELRPSnhatiqsivhavgiQPGVPAPCCVPDKMSSL-TL 78

                        90       100
                ....*....|....*....|....*...
gi 27436881 328 VSIKEGGRtrpqVV--SLPNMRVQKCSC 353
Cdd:cd13763  79 LYFDENRN----VVlkNYPNMTVESCAC 102
TGF_beta_BMP2 cd19390
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 261-300 6.80e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.


Pssm-ID: 381660  Cd Length: 103  Bit Score: 41.51  E-value: 6.80e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 27436881 261 TRCCRQEMYIDLQGMKWAKnWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19390   1 SSCKRHPLYVDFSDVGWND-WIVAPPGYHAFYCHGECPFP 39
TGF_beta_BMP4_BMP2B cd19391
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 ...
 263-300 7.32e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins; BMP-4, also termed BMP-2B, induces cartilage and bone formation. It also acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381661  Cd Length: 107  Bit Score: 41.58  E-value: 7.32e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19391   7 CRRHSLYVDFSDVGW-NDWIVAPPGYQAFYCHGDCPFP 43
TGF_beta_BMP2_like cd13760
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 263-301 8.60e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2), 4 (BMP-4) and similar proteins; The family includes BMP2 and BMP4 (also known as BMP2B), both of which induce cartilage and bone formation. BMP-2 stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP-4 acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381638  Cd Length: 102  Bit Score: 41.32  E-value: 8.60e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQPP 301
Cdd:cd13760   1 CRRHSLYVDFSDVGW-NDWIVAPPGYHAFYCHGECPFPL 38
TGF_beta_INHBC_E cd19406
transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), ...
 263-297 1.19e-04

transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381676  Cd Length: 104  Bit Score: 40.91  E-value: 1.19e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTC 297
Cdd:cd19406   1 CCRRDFYVDFKDIGW-NDWIIKPEGYQMNYCMGQC 34
TGF_beta_INHA cd13754
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and ...
 263-353 1.52e-04

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland.


Pssm-ID: 381632  Cd Length: 89  Bit Score: 40.13  E-value: 1.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTCqQPPEALAFNwpfLGPRQCIASETASL-PMIVSIKEGGRTRPQVV 341
Cdd:cd13754   2 CHRASLNISFEELGWG-NWIVHPSSFTFHYCHGTC-SSSHGLTPA---LGIQLCCAAVPGTMrSLRVRTTSDGGYSFKYE 76

                        90
                ....*....|..
gi 27436881 342 SLPNMRVQKCSC 353
Cdd:cd13754  77 TVPNILTQDCAC 88
PHA02913 PHA02913
TGF-beta-like protein; Provisional
 263-353 2.07e-04

TGF-beta-like protein; Provisional


Pssm-ID: 177497  Cd Length: 172  Bit Score: 41.54  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881  263 CCRQEMYIDLQG-MKWakNWVLEPPGFLAYECVGTCQQP-------PEALAF--NWPFLGPRQCIASETASlPMIVSIKE 332
Cdd:PHA02913  77 CCIRDFNIDFKAdMGM--KWILKPEGTHANLCIGICSISnhkkinlMYGTAFkhHMPDNTIPFCCAPIKMK-NFIIAYKE 153

                         90       100
                 ....*....|....*....|.
gi 27436881  333 GGRTRPQVVSlpNMRVQKCSC 353
Cdd:PHA02913 154 GRKIKTDNIK--NFKILECAC 172
TGF_beta_BMP7 cd19397
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 ...
 263-300 2.16e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.


Pssm-ID: 381667  Cd Length: 107  Bit Score: 40.41  E-value: 2.16e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19397   6 CKKHELYVSFRDLGW-QDWIIAPEGYAAYYCEGECAFP 42
TGF_beta_TGFB1 cd19384
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 263-354 2.64e-04

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins; TGF-beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.


Pssm-ID: 381654  Cd Length: 99  Bit Score: 39.85  E-value: 2.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436881 263 CCRQEMYIDL-QGMKWakNWVLEPPGFLAYECVGTC-------QQPPEALAF---NWPFLGPRQCIASETAS-LPMIVSI 330
Cdd:cd19384   2 CCVRQLYIDFrKDLGW--KWIHEPKGYHANFCLGPCpyiwsldTQYSKVLALynqHNPGASAAPCCVPQALEpLPIVYYV 79

                        90       100
                ....*....|....*....|....
gi 27436881 331 kegGRTRpQVVSLPNMRVQKCSCA 354
Cdd:cd19384  80 ---GRKP-KVEQLSNMIVRSCKCS 99
TGF_beta_DPP cd19392
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 263-300 2.71e-04

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.


Pssm-ID: 381662  Cd Length: 109  Bit Score: 39.82  E-value: 2.71e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19392   8 CRRHPLYVDFSDVGW-DDWIVAPLGYDAYYCNGECPFP 44
TGF_beta_INHBA cd19404
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) ...
 263-297 8.56e-04

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381674  Cd Length: 108  Bit Score: 38.37  E-value: 8.56e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 27436881 263 CCRQEMYIDLQGMKWAkNWVLEPPGFLAYECVGTC 297
Cdd:cd19404   3 CCKKQFYVSFKDIGWS-DWIIAPSGYHANYCEGEC 36
TGF_beta_GDF5 cd19399
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 262-300 9.07e-04

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.


Pssm-ID: 381669  Cd Length: 103  Bit Score: 38.45  E-value: 9.07e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 27436881 262 RCCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19399   1 RCSRKALHVNFKDMGW-DDWIIAPLEYEAFHCEGLCEFP 38
TGF_beta_GDF10 cd19394
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 258-300 1.29e-03

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins; GDF10, also termed bone morphogenetic protein 3B (BMP-3B), or bone-inducing protein (BIP), is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381664  Cd Length: 112  Bit Score: 37.97  E-value: 1.29e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 27436881 258 TEGTRCCRQEMYIDLQGMKWAKnWVLEPPGFLAYECVGTCQQP 300
Cdd:cd19394   5 SEPRVCSRRYLKVDFADIGWSE-WIISPKSFDAYYCAGACEFP 46
TGF_beta_BMP5 cd19395
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 ...
 263-303 1.38e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.


Pssm-ID: 381665  Cd Length: 113  Bit Score: 38.14  E-value: 1.38e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQPPEA 303
Cdd:cd19395  12 CKKHELYVSFRDLGW-QDWIIAPEGYAAFYCDGECSFPLNA 51
TGF_beta_GDF1_3_like cd13764
transforming growth factor beta (TGF-beta) like domain found in embryonic growth ...
 263-300 1.48e-03

transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins; The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.


Pssm-ID: 381642  Cd Length: 102  Bit Score: 37.83  E-value: 1.48e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQP 300
Cdd:cd13764   1 CKKRRLYISFRDVGW-QNWIIAPQGYMANYCHGECPFP 37
TGF_beta_GDF11 cd19389
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 250-298 3.17e-03

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381659  Cd Length: 109  Bit Score: 36.94  E-value: 3.17e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 27436881 250 DCDPEApmTEgTRCCRQEMYIDLQGMKWakNWVLEPPGFLAYECVGTCQ 298
Cdd:cd19389   5 DCDEHS--TE-SRCCRYPLTVDFEAFGW--DWIIAPKRYKANYCSGQCE 48
TGF_beta_BMP6 cd19396
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ...
 263-303 3.67e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.


Pssm-ID: 381666  Cd Length: 103  Bit Score: 36.56  E-value: 3.67e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTCQQPPEA 303
Cdd:cd19396   2 CRKHELYVSFQDLGW-QDWIIAPKGYAANYCDGECSFPLNA 41
TGF_beta_GDP9_9B_like cd13762
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 263-297 3.92e-03

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381640  Cd Length: 104  Bit Score: 36.66  E-value: 3.92e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 27436881 263 CCRQEMYIDLQGMKWaKNWVLEPPGFLAYECVGTC 297
Cdd:cd13762   3 CRRHRLRVRFRDLKW-NGWIIAPTRYTANYCKGTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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