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Conserved domains on  [gi|4580424|ref|NP_001595|]
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paired box protein Pax-6 isoform b [Homo sapiens]

Protein Classification

paired box protein( domain architecture ID 11265415)

paired box protein similar to mammalian Pax6, a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas, and Drosophila gooseberry, which is involved in defining the polarity of embryonic segments

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
4-142 2.93e-80

Paired Box domain;


:

Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 243.38  E-value: 2.93e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424       4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSKILGRYYETGSIRPR 83
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLC--------------VSHGCVSKILGRYYETGSIRPG 66

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 4580424      84 AIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 142
Cdd:smart00351  67 AIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
226-281 1.32e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.12  E-value: 1.32e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4580424    226 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 281
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
4-142 2.93e-80

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 243.38  E-value: 2.93e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424       4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSKILGRYYETGSIRPR 83
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLC--------------VSHGCVSKILGRYYETGSIRPG 66

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 4580424      84 AIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 142
Cdd:smart00351  67 AIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 5-145 7.06e-79

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 240.01  E-value: 7.06e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424    5 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSKILGRYYETGSIRPRA 84
Cdd:cd00131   2 QGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLR--------------VSHGCVSKILNRYYETGSIRPGA 67

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4580424   85 IGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLA 145
Cdd:cd00131  68 IGGSKPRVATPEVVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNKA 128
PAX pfam00292
'Paired box' domain;
4-142 1.05e-76

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 234.38  E-value: 1.05e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424      4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSKILGRYYETGSIRPR 83
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLR--------------VSHGCVSKILGRYYETGSIRPG 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4580424     84 AIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 142
Cdd:pfam00292  67 VIGGSKPKVATPEVVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
226-281 1.32e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.12  E-value: 1.32e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4580424    226 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 281
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 225-280 4.30e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.24  E-value: 4.30e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4580424     225 QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWR 280
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 226-283 1.04e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.46  E-value: 1.04e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4580424  226 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREE 283
Cdd:cd00086   2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
199-302 6.81e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 6.81e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424  199 ENTNSISSNGEDSDEAqmrlqlKRKlqRNRTsfTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAK 278
Cdd:COG5576  36 DSEMKLERKQDGSSPP------KSK--RRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105

                        90       100       110
                ....*....|....*....|....*....|..
gi 4580424  279 WRREEKLRNQRRQASN--------TPSHIPIS 302
Cdd:COG5576 106 EKKKRSGKVEQRPGEEeadlakigSLSTGQIS 137
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
4-142 2.93e-80

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 243.38  E-value: 2.93e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424       4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSKILGRYYETGSIRPR 83
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLC--------------VSHGCVSKILGRYYETGSIRPG 66

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 4580424      84 AIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 142
Cdd:smart00351  67 AIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 5-145 7.06e-79

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 240.01  E-value: 7.06e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424    5 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSKILGRYYETGSIRPRA 84
Cdd:cd00131   2 QGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLR--------------VSHGCVSKILNRYYETGSIRPGA 67

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4580424   85 IGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLA 145
Cdd:cd00131  68 IGGSKPRVATPEVVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNKA 128
PAX pfam00292
'Paired box' domain;
4-142 1.05e-76

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 234.38  E-value: 1.05e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424      4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSKILGRYYETGSIRPR 83
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLR--------------VSHGCVSKILGRYYETGSIRPG 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4580424     84 AIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 142
Cdd:pfam00292  67 VIGGSKPKVATPEVVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
226-281 1.32e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.12  E-value: 1.32e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4580424    226 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 281
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 225-280 4.30e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.24  E-value: 4.30e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4580424     225 QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWR 280
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 226-283 1.04e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.46  E-value: 1.04e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4580424  226 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREE 283
Cdd:cd00086   2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
199-302 6.81e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 6.81e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4580424  199 ENTNSISSNGEDSDEAqmrlqlKRKlqRNRTsfTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAK 278
Cdd:COG5576  36 DSEMKLERKQDGSSPP------KSK--RRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105

                        90       100       110
                ....*....|....*....|....*....|..
gi 4580424  279 WRREEKLRNQRRQASN--------TPSHIPIS 302
Cdd:COG5576 106 EKKKRSGKVEQRPGEEeadlakigSLSTGQIS 137
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-89 3.02e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.51  E-value: 3.02e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4580424   18 GRPLPDSTRQKIVE-LAHSGARPCDISRILqthadakvqvldnqNVSNGCVSKILGRYYETGSIRPRAIGGSK 89
Cdd:cd00090   1 LKALSDPTRLRILRlLLEGPLTVSELAERL--------------GLSQSTVSRHLKKLEEAGLVESRREGRRV 59
HTH_32 pfam13565
Homeodomain-like domain;
67-141 4.94e-03

Homeodomain-like domain;


Pssm-ID: 463923 [Multi-domain]  Cd Length: 73  Bit Score: 35.74  E-value: 4.94e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4580424     67 VSKILGRYYETG--SIRPRAIGGSKPRVaTPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVctndNIPSVSSINRVL 141
Cdd:pfam13565   2 VYRWRKRYNEEGleGLEDRPRRGRPRKL-TDEQEARLLALLCEEPRWSPRLLAERLEEEFG----VKVSRSTVRRIL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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