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Genome Displays Related Resources Gene HomoloGene MANE RefSeq
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Report for CCDS6794.2 (current version)
CCDS |
Status |
Species |
Chrom. |
Gene |
CCDS Release |
NCBI Annotation Release |
Ensembl Annotation Release |
Links |
6794.2 |
Public |
Homo sapiens |
9 |
ALAD |
24 |
110 |
108 |
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Public Note for CCDS 6794.1 |
The coding region has been updated to start at an alternate in-frame start codon that is supported by conservation data or a publication. PMID:3463993 suggests that the downstream AUG codon is the translation start site from evidence provided by N-terminal sequencing of the human protein. Although this may be the dominant translation start site, it is possible that some translation also occurs from the upstream AUG which is 27 nt upstream of the annotated start for this CCDS. The upstream AUG is in a weak Kozak context so a possible mechanism is that leaky scanning by ribosomes occurs so that, in most cases, ribosomes continue scanning and use the downstream AUG as the translation initiation site. |
Public since: CCDS release 1, NCBI annotation release 35.1, Ensembl annotation release 23
Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)
Attributes |
CDS uses downstream AUG |
Sequence IDs included in CCDS 6794.2
Original |
Current |
Source |
Nucleotide ID |
Protein ID |
MANE |
Status in CCDS |
Seq. Status |
Links |
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EBI |
ENST00000409155.8 |
ENSP00000386284.3 |
MANE Select |
Accepted |
alive |
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NCBI |
NM_000031.6 |
NP_000022.3 |
MANE Select |
Accepted |
alive |
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RefSeq |
Length |
Related UniProtKB/SwissProt |
Length |
Identity |
Gaps |
Mismatches |
NP_000022.3 |
330 |
P13716-1 |
330 |
100% |
0 |
0 |
Chromosomal Locations for CCDS 6794.2
Assembly GRCh38.p14 (GCF_000001405.40)
CCDS Sequence Data |
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Blue highlighting indicates alternating exons. | Red highlighting indicates amino acids encoded across a splice junction. | | Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair. |
Nucleotide Sequence (993 nt): ATGCAGCCCCAGTCCGTTCTGCACAGCGGCTACTTCCACCCACTACTTCGGGCCTGGCAGACAGCCACCA CCACCCTCAATGCCTCCAACCTCATCTACCCCATCTTTGTCACGGATGTTCCTGATGACATACAGCCTAT CACCAGCCTCCCAGGAGTGGCCAGGTATGGTGTGAAGCGGCTGGAAGAGATGCTGAGGCCCTTGGTGGAA GAGGGCCTACGCTGTGTCTTGATCTTTGGCGTCCCCAGCAGAGTTCCCAAGGACGAGCGGGGTTCCGCAG CTGACTCCGAGGAGTCCCCAGCTATTGAGGCAATCCATCTGTTGAGGAAGACCTTCCCCAACCTCCTGGT GGCCTGTGATGTCTGCCTGTGTCCCTACACCTCCCATGGTCACTGCGGGCTCCTGAGTGAAAACGGAGCA TTCCGGGCTGAGGAGAGCCGCCAGCGGCTGGCTGAGGTGGCATTGGCGTATGCCAAGGCAGGATGTCAGG TGGTAGCCCCGTCGGACATGATGGATGGACGCGTGGAAGCCATCAAAGAGGCCCTGATGGCACATGGACT TGGCAACAGGGTATCGGTGATGAGCTACAGTGCCAAATTTGCTTCCTGTTTCTATGGCCCTTTCCGGGAT GCAGCTAAGTCAAGCCCAGCTTTTGGGGACCGCCGCTGCTACCAGCTGCCCCCTGGAGCACGAGGCCTGG CTCTCCGAGCTGTGGACCGGGATGTACGGGAAGGAGCTGACATGCTCATGGTGAAGCCGGGAATGCCCTA CCTGGACATCGTGCGGGAGGTAAAGGACAAGCACCCTGACCTCCCTCTCGCCGTGTACCACGTCTCTGGA GAGTTTGCCATGCTGTGGCATGGAGCCCAGGCCGGGGCATTTGATCTCAAGGCTGCCGTACTGGAGGCCA TGACTGCCTTCCGCAGAGCAGGTGCTGACATCATCATCACCTACTACACACCGCAGCTGCTGCAGTGGCT GAAGGAGGAATGA
Translation (330 aa): MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVE EGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGA FRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRD AAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSG EFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE
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